3LIB

Crystal Structure of the extracellular domain of the putative histidine kinase mmHK1S-Z3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3liba_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
B	d3libb_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
C	d3libc_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
D	d3libd_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
E	d3libe_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
F	d3libf_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
G	d3libg_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
H	d3libh_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
I	d3libi_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)
J	d3libj_	Alpha and beta proteins (a+b)	Profilin-like	Sensory domain-like	Histidine kinase family 1 (HK1) sensor domains	MM_2965	Methanosarcina frisia (Methanosarcina mazei ) [TaxId: 2209 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	dCache_1_like_1	e3libA1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
A	Cache_3-Cache_2_1	e3libA2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
B	dCache_1_like_1	e3libB1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
B	Cache_3-Cache_2_1	e3libB2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
C	dCache_1_like_1	e3libC1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
C	Cache_3-Cache_2_1	e3libC2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
D	dCache_1_like_1	e3libD1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
D	Cache_3-Cache_2_1	e3libD2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
E	dCache_1_like_1	e3libE1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
E	Cache_3-Cache_2_1	e3libE2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
F	dCache_1_like_1	e3libF1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
F	Cache_3-Cache_2_1	e3libF2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
G	dCache_1_like_1	e3libG1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
G	Cache_3-Cache_2_1	e3libG2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
H	dCache_1_like_1	e3libH1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
H	Cache_3-Cache_2_1	e3libH2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
I	dCache_1_like_1	e3libI1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
I	Cache_3-Cache_2_1	e3libI2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)
J	dCache_1_like_1	e3libJ1	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: dCache_1_like_1	ECOD (1.6)
J	Cache_3-Cache_2_1	e3libJ2	A: a+b three layers	X: Profilin-like	H: sensor domains (From Topology)	T: sensor domains	F: Cache_3-Cache_2_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
B	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
C	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
D	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
E	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
F	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
G	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
H	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
I	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)
J	3.30.450.20	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	PAS domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	PF02743	Cache domain (dCache_1)	Cache domain	Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptor ...	Double cache domain 1 covers the last three strands from the membrane distal PAS-like domain, the first two strands of the membrane proximal domain, and the connecting elements between the two domains [2]. This domain when present in chemoreceptors recognise several signals such as proteinogenic amino acids, GABA, Histamine and polyamines, decanoic acid, Autoinducer-2, purine derivatives, quaternary amines, citrate and taurine, among others. When associated with histidine kinases, it recognises C3/C4-dicarboxylic acids, Spermine, guanosine and Autoinducer-2 (Mantilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1 https://doi.org/10.1093/femsre/fuab043).	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	Hypothetical sensory transduction histidine kinase	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation cellular process signal transduction cell communication	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000014	PAS domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR033479	Double Cache domain 1	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR003660	HAMP domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR011495	Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR001610	PAC motif	Repeat
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR000700	PAS-associated, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR013655	PAS fold-3	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J	IPR005467	Histidine kinase domain	Domain

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3LIB

Crystal Structure of the extracellular domain of the putative histidine kinase mmHK1S-Z3

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage