3L8H

Crystal Structure of D,D-heptose 1.7-bisphosphate phosphatase from B. bronchiseptica complexed with magnesium and phosphate

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Histidinol phosphatase-like	8082852	4002690	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	HAD-like	8082853	3001890	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	HAD-like	8082853	3001890	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	HAD-like	8082853	3001890	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HAD-like	8082853	3001890	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_like	e3l8hA1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_like	ECOD (1.6)
B	Hydrolase_like	e3l8hB1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_like	ECOD (1.6)
C	Hydrolase_like	e3l8hC1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_like	ECOD (1.6)
D	Hydrolase_like	e3l8hD1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: HAD-like	F: Hydrolase_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
B	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
C	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)
D	3.40.50.1000	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	HAD superfamily/HAD-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF13242	HAD-hyrolase-like (Hydrolase_like)	HAD-hyrolase-like	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Putative haloacid dehalogenase-like hydrolase	phosphoric ester hydrolase activity D,D-heptose 1,7-bisphosphate phosphatase activity hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding transition metal ion binding zinc ion binding	lipopolysaccharide biosynthetic process cellular biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process lipopolysaccharide metabolic process lipopolysaccharide core region biosynthetic process organic substance metabolic process polysaccharide metabolic process oligosaccharide biosynthetic process organic substance biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process lipopolysaccharide biosynthetic process cellular biosynthetic process lipid biosynthetic process carbohydrate derivative metabolic process lipopolysaccharide metabolic process lipopolysaccharide core region biosynthetic process organic substance metabolic process polysaccharide metabolic process oligosaccharide biosynthetic process organic substance biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process polysaccharide biosynthetic process carbohydrate biosynthetic process oligosaccharide metabolic process cellular metabolic process liposaccharide metabolic process primary metabolic process lipopolysaccharide core region metabolic process macromolecule biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process lipid metabolic process nucleotide-sugar metabolic process nucleobase-containing compound biosynthetic process ADP-L-glycero-beta-D-manno-heptose biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process ADP-L-glycero-beta-D-manno-heptose metabolic process nucleobase-containing small molecule metabolic process organic cyclic compound biosynthetic process small molecule metabolic process nucleotide-sugar biosynthetic process phosphorus metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR004446	D,D-heptose 1,7-bisphosphate phosphatase	Family
A, B, C, D	IPR006543	Histidinol-phosphate phosphatase	Domain
A, B, C, D	IPR006549	HAD-superfamily hydrolase,subfamily IIIA	Domain
A, B, C, D	IPR036412	HAD-like superfamily	Homologous Superfamily
A, B, C, D	IPR023214	HAD superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.