3L82

X-ray Crystal structure of TRF1 and Fbx4 complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3l82a_	All alpha proteins	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	Telomeric repeat binding factor (TRF) dimerisation domain	TRF1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Telomeric repeat binding factor (TRF) dimerisation domain	8039441	3000229	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08558	e3l82A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08558	ECOD (1.6)
B	F_UNCLASSIFIED	e3l82B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.40.210	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat	Telomere repeat-binding factor, dimerisation domain	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08558	Telomere repeat binding factor (TRF) (TRF)	Telomere repeat binding factor (TRF)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Telomeric repeat-binding factor 1	ankyrin repeat binding protein binding binding protein domain specific binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding telomeric DNA binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding ankyrin repeat binding protein binding binding protein domain specific binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding telomeric DNA binding double-stranded telomeric DNA binding double-stranded DNA binding G-rich strand telomeric DNA binding sequence-specific single stranded DNA binding single-stranded telomeric DNA binding single-stranded DNA binding cytoskeletal protein binding microtubule binding tubulin binding identical protein binding protein homodimerization activity protein dimerization activity DNA binding, bending molecular adaptor activity	regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of shelterin complex assembly positive regulation of biological process telomere organization positive regulation of shelterin complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly shelterin complex assembly protein-containing complex assembly regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of shelterin complex assembly positive regulation of biological process telomere organization positive regulation of shelterin complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly cellular component assembly shelterin complex assembly protein-containing complex assembly cellular component organization or biogenesis positive regulation of cellular process regulation of biological process protein-containing complex organization positive regulation of cellular component biogenesis biological regulation chromosome organization protein-DNA complex assembly regulation of cellular component biogenesis organelle organization cellular process establishment of organelle localization meiotic chromosome segregation cellular localization sexual reproduction reproductive process meiotic cell cycle process localization telomere localization meiosis I chromosome localization organelle localization establishment of localization in cell meiotic nuclear division cell cycle chromosome segregation cell cycle process meiotic cell cycle organelle fission meiotic telomere clustering establishment of localization chromosome organization involved in meiotic cell cycle nuclear division chromosome localization to nuclear envelope involved in homologous chromosome segregation meiosis I cell cycle process nuclear chromosome segregation homologous chromosome segregation establishment of chromosome localization cellular biosynthetic process RNA-templated DNA biosynthetic process nucleobase-containing compound metabolic process telomere maintenance via telomere lengthening nucleic acid biosynthetic process organic substance metabolic process organic substance biosynthetic process telomere maintenance via telomerase cellular metabolic process primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process telomere maintenance organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process metabolic process macromolecule metabolic process DNA biosynthetic process cell division regulation of establishment of protein-containing complex localization to telomere regulation of localization establishment of protein-containing complex localization to telomere negative regulation of biological process protein-containing complex localization negative regulation of establishment of protein-containing complex localization to telomere cellular macromolecule localization macromolecule localization regulation of establishment of RNA localization to telomere negative regulation of establishment of RNA localization to telomere establishment of RNA localization to telomere establishment of RNA localization RNA localization formation of extrachromosomal circular DNA telomere maintenance via telomere trimming t-circle formation telomeric loop disassembly telomeric D-loop disassembly regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity regulation of DNA biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of transferase activity negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process regulation of molecular function negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process regulation of telomerase activity negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of telomerase activity negative regulation of molecular function regulation of macromolecule metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process negative regulation of DNA metabolic process negative regulation of telomere maintenance negative regulation of telomere maintenance via telomerase negative regulation of chromosome organization negative regulation of cellular component organization regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening regulation of telomere maintenance via telomerase negative regulation of organelle organization negative regulation of telomere maintenance via semi-conservative replication negative regulation of cell cycle cell cycle DNA replication telomere maintenance via semi-conservative replication regulation of cell cycle process DNA replication nuclear DNA replication regulation of cell cycle DNA-templated DNA replication negative regulation of cell cycle process regulation of telomere maintenance via semi-conservative replication regulation of telomeric loop disassembly regulation of telomeric D-loop disassembly negative regulation of telomeric D-loop disassembly negative regulation of telomeric loop disassembly positive regulation of organelle organization positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of chromosome organization positive regulation of DNA metabolic process telomere capping protein localization establishment of protein localization to telomere establishment of protein localization regulation of protein localization negative regulation of protein localization to chromosome, telomeric region regulation of protein localization to chromosome, telomeric region establishment of protein localization to chromosome regulation of establishment of protein localization to chromosome negative regulation of protein localization regulation of establishment of protein localization negative regulation of establishment of protein localization protein localization to chromosome, telomeric region negative regulation of establishment of protein localization to telomere establishment of protein localization to organelle protein localization to chromosome regulation of cellular localization protein localization to organelle regulation of establishment of protein localization to telomere negative regulation of hydrolase activity regulation of nuclease activity regulation of hydrolase activity negative regulation of exonuclease activity regulation of exonuclease activity negative regulation of nuclease activity negative regulation of DNA replication regulation of DNA replication	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex protein-DNA complex nuclear protein-containing complex chromosome chromosomal region telomere cap complex chromosome, telomeric repeat region chromosome, telomeric region shelterin complex nuclear telomere cap complex cytoplasm nucleoplasm fibrillar center cytoskeleton spindle microtubule cytoskeleton nuclear body
B	F-box only protein 4	ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity identical protein binding ubiquitin-like ligase-substrate adaptor activity enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	cellular homeostasis homeostatic process protein destabilization regulation of protein stability biological regulation regulation of biological quality cellular response to stimulus response to ionizing radiation response to stimulus cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular process cellular response to radiation cellular homeostasis homeostatic process protein destabilization regulation of protein stability biological regulation regulation of biological quality cellular response to stimulus response to ionizing radiation response to stimulus cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular process cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process protein ubiquitination positive regulation of macromolecule metabolic process protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of biological process organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process organic substance catabolic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process post-transcriptional regulation of gene expression regulation of gene expression biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process regulation of cellular response to stress negative regulation of cell cycle cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of signaling regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response regulation of response to stimulus signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint cellular senescence telomere organization chromosome organization DNA metabolic process nucleic acid metabolic process telomere maintenance cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization cellular component organization or biogenesis protein polyubiquitination positive regulation of organelle organization regulation of DNA biosynthetic process positive regulation of macromolecule biosynthetic process RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening positive regulation of telomere maintenance via telomere lengthening regulation of nucleobase-containing compound metabolic process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of telomere maintenance via telomerase organic cyclic compound biosynthetic process DNA biosynthetic process regulation of DNA metabolic process regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization positive regulation of cellular metabolic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process telomere maintenance via telomerase positive regulation of DNA biosynthetic process nucleobase-containing compound biosynthetic process regulation of telomere maintenance via telomerase positive regulation of cellular biosynthetic process negative regulation of cell population proliferation fibroblast proliferation cell population proliferation regulation of fibroblast proliferation regulation of cell population proliferation negative regulation of fibroblast proliferation common myeloid progenitor cell proliferation protein localization regulation of localization cellular localization regulation of protein localization regulation of protein localization to nucleus protein localization to nucleus negative regulation of protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle negative regulation of protein localization regulation of protein polyubiquitination positive regulation of protein polyubiquitination	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cullin-RING ubiquitin ligase complex protein-containing complex ubiquitin ligase complex catalytic complex SCF ubiquitin ligase complex transferase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR017930	Myb domain	Domain
A	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
A	IPR013867	Telomere repeat-binding factor, dimerisation domain	Domain
A	IPR036507	Telomere repeat-binding factor, dimerisation domain superfamily	Homologous Superfamily
A	IPR017357	Telomeric repeat-binding factor 1/2	Family
A	IPR001005	SANT/Myb domain	Domain
B	IPR001810	F-box domain	Domain
B	IPR039588	F-box only protein 4	Family
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B	IPR036047	F-box-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P54274	Crohn disease ovarian cancer ulcerative colitis
B	Pharos: Q9UKT5	acute myeloid leukemia malignant ependymoma esophageal cancer medulloblastoma glioblastoma ovarian cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.