3L2J

Dimeric structure of the ligand-free extracellular domain of the human parathyroid hormone receptor (PTH1R)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Type 2 solute binding protein-like	8058187	3000083	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SBP_bac_1_C,SBP_bac_1_N_2	e3l2jA2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_C,SBP_bac_1_N_2	ECOD (1.6)
A	HRM	e3l2jA4	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)
B	SBP_bac_1_C,SBP_bac_1_N_2	e3l2jB2	A: a/b three-layered sandwiches	X: Periplasmic binding protein-like II (From Topology)	H: Periplasmic binding protein-like II (From Topology)	T: Periplasmic binding protein-like II	F: SBP_bac_1_C,SBP_bac_1_N_2	ECOD (1.6)
B	HRM	e3l2jB4	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: HRM	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	4.10.1240.10	Few Secondary Structures	Irregular	Hormone receptor fold	GPCR, family 2, extracellular hormone receptor domain	CATH (4.3.0)
B	4.10.1240.10	Few Secondary Structures	Irregular	Hormone receptor fold	GPCR, family 2, extracellular hormone receptor domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00002	7 transmembrane receptor (Secretin family) (7tm_2)	7 transmembrane receptor (Secretin family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Fusion protein of Maltose-binding periplasmic protein and Parathyroid hormone/parathyroid hormone-related peptide receptor	transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding identical protein binding protein binding protein homodimerization activity protein dimerization activity amide binding peptide hormone binding transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity oligosaccharide binding binding disaccharide binding carbohydrate binding maltose binding identical protein binding protein binding protein homodimerization activity protein dimerization activity amide binding peptide hormone binding hormone binding peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity parathyroid hormone receptor activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process cell chemotaxis chemotaxis response to external stimulus cellular response to chemical stimulus taxis response to chemical cell migration cell motility locomotion localization transport organic substance transport carbohydrate transport oligosaccharide transport disaccharide transport establishment of localization maltose transport polysaccharide localization dextrin transport macromolecule localization maltodextrin transmembrane transport polysaccharide transport response to organic substance response to disaccharide response to oxygen-containing compound detection of maltose stimulus detection of stimulus response to carbohydrate detection of chemical stimulus detection of disaccharide stimulus response to maltose detection of carbohydrate stimulus developmental process multicellular organismal process ossification bone mineralization animal organ development anatomical structure development biomineral tissue development tissue development multicellular organism development skeletal system development system development cell population proliferation regulation of biological process regulation of cellular process signaling biological regulation cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis osteoblast development cellular developmental process cell differentiation cell development osteoblast differentiation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development anatomical structure maturation cell maturation developmental maturation adenylate cyclase-activating G protein-coupled receptor signaling pathway positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of biological process positive regulation of cellular process cell surface receptor signaling pathway negative regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process phospholipase C-activating G protein-coupled receptor signaling pathway connective tissue development chondrocyte differentiation cartilage development regulation of inositol phosphate biosynthetic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process polyol biosynthetic process organic substance biosynthetic process small molecule metabolic process phosphorus metabolic process polyol metabolic process positive regulation of phosphorus metabolic process regulation of alcohol biosynthetic process cellular metabolic process carbohydrate biosynthetic process regulation of cellular metabolic process primary metabolic process positive regulation of inositol phosphate biosynthetic process biosynthetic process organophosphate biosynthetic process inositol phosphate biosynthetic process regulation of phosphorus metabolic process metabolic process positive regulation of carbohydrate metabolic process regulation of metabolic process cellular biosynthetic process organic hydroxy compound metabolic process positive regulation of cellular metabolic process alcohol metabolic process inositol phosphate metabolic process organic substance metabolic process positive regulation of biosynthetic process regulation of carbohydrate metabolic process regulation of biosynthetic process carbohydrate metabolic process small molecule biosynthetic process regulation of cellular biosynthetic process organophosphate metabolic process organic hydroxy compound biosynthetic process alcohol biosynthetic process regulation of carbohydrate biosynthetic process positive regulation of small molecule metabolic process positive regulation of alcohol biosynthetic process positive regulation of cellular biosynthetic process multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis tissue homeostasis bone resorption G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity transporter complex ATP-binding cassette (ABC) transporter complex cell periphery transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing maltose transport complex periplasmic space outer membrane-bounded periplasmic space cell envelope apical part of cell plasma membrane region apical plasma membrane basal part of cell basal plasma membrane basolateral plasma membrane intracellular anatomical structure cytoplasm receptor complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006061	Solute-binding family 1, conserved site	Conserved Site
A, B	IPR006060	Maltose/Cyclodextrin ABC transporter, substrate-binding protein	Family
A, B	IPR006059	Bacterial-type extracellular solute-binding protein	Family
A, B	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
A, B	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
A, B	IPR002170	GPCR, family 2, parathyroid hormone receptor	Family
A, B	IPR000832	GPCR, family 2, secretin-like	Family
A, B	IPR017981	GPCR, family 2-like, 7TM	Domain
A, B	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q03431	Eiken syndrome metaphyseal chondrodysplasia, Jansen type rickets chondrodysplasia Blomstrand type Ollier disease primary failure of tooth eruption hyperparathyroidism medulloblastoma osteogenesis imperfecta psoriasis adrenal cortex adenoma breast carcinoma Glucocorticoid Induced Osteoporosis large cell medulloblastoma malignant glioma Eiken syndrome metaphyseal chondrodysplasia, Jansen type rickets chondrodysplasia Blomstrand type Ollier disease primary failure of tooth eruption hyperparathyroidism medulloblastoma osteogenesis imperfecta psoriasis adrenal cortex adenoma breast carcinoma Glucocorticoid Induced Osteoporosis large cell medulloblastoma malignant glioma postmenopausal osteoporosis adrenal cortex carcinoma hepatocellular carcinoma hypoparathyroidism lung disease malignant mesothelioma tooth ankylosis glioblastoma intellectual disability

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.