3KYI

Crystal structure of the phosphorylated P1 domain of CheA3 in complex with CheY6 from R. sphaeroides

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3kyib1	Alpha and beta proteins (a/b)	Flavodoxin-like	CheY-like	automated matches	automated matches	Rhodopseudomonas sphaeroides (Cereibacter sphaeroides ) [TaxId: 1063 ],	SCOPe (2.08)
B	d3kyib2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Rhodopseudomonas sphaeroides (Cereibacter sphaeroides ) [TaxId: 1063 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Chemotaxis protein CheA P1 domain	8073993	4002977	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Histidine-containing phosphotransfer domain HPT domain	8073994	3001634	SCOP2 (2022-06-29)
B	SCOP2 Family	CheY-related	8072851	4003632	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	CheY-like	8072852	3001156	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01627	e3kyiA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Histidine-containing phosphotransfer domain, HPT domain (From Topology)	T: Histidine-containing phosphotransfer domain, HPT domain	F: PF01627	ECOD (1.6)
B	PF00072	e3kyiB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF00072	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.120.160	Mainly Alpha	Up-down Bundle	Four Helix Bundle (Hemerythrin (Met), subunit A)	HPT domain	CATH (4.3.0)
B	3.40.50.2300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Response regulator	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01627	Hpt domain (Hpt)	Hpt domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Putative histidine protein kinase	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, nitrogenous group as acceptor phosphotransferase activity, alcohol group as acceptor protein histidine kinase activity transferase activity, transferring phosphorus-containing groups	chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process signaling biological regulation intracellular signal transduction cell communication chemotaxis response to stimulus taxis response to chemical response to external stimulus locomotion cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process signaling biological regulation intracellular signal transduction cell communication cellular process signal transduction	-
B	CheY6 protein	-	cellular response to stimulus regulation of biological process phosphorelay signal transduction system regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication cellular process signal transduction	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002545	CheW-like domain	Domain
A	IPR036641	HPT domain superfamily	Homologous Superfamily
A	IPR008207	Signal transduction histidine kinase, phosphotransfer (Hpt) domain	Domain
A	IPR036061	CheW-like domain superfamily	Homologous Superfamily
A	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
B	IPR011006	CheY-like superfamily	Homologous Superfamily
B	IPR001789	Signal transduction response regulator, receiver domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	NEP	Parent Component: HIS RESID: AA0035 PSI-MOD : 1'-phospho-L-histidine MOD:00044

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.