Annotations: 3KXE

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2 Family	ParD antitoxin-like	8044732	4004105	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Ribbon-helix-helix	8052310	3000295	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	Ribbon-helix-helix	8052310	3000295	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05016	e3kxeA1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
B	PF05016	e3kxeB1	A: a+b two layers	X: RelE-like	H: RelE-like (From Topology)	T: RelE-like	F: PF05016	ECOD (1.6)
C	PF03693	e3kxeC2	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: PF03693	ECOD (1.6)
C	PF03693	e3kxeC1	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF03693	ECOD (1.6)
D	PF03693	e3kxeD2	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: PF03693	ECOD (1.6)
D	PF03693	e3kxeD3	A: extended segments	X: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	H: ParE2-associated antitoxin 2 (PaaA2) (From Topology)	T: ParE2-associated antitoxin 2 (PaaA2)	F: PF03693	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
B	3.30.2310.20	Alpha Beta	2-Layer Sandwich	YaeB-like fold	RelE-like	CATH (4.3.0)
C	6.10.10.120	Special	Helix non-globular	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
D	6.10.10.120	Special	Helix non-globular	Helicase, Ruva Protein	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05016	ParE toxin of type II toxin-antitoxin system, parDE (ParE_toxin)	ParE toxin of type II toxin-antitoxin system, parDE	ParE is the toxin family of a type II toxin-antitoxin family. It is toxic towards DNA gyrase, but is neutralised by the antitoxin ParD. The family also encompasses RelE/ParE described in [2].	Domain
C, D	PF03693	Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH (ParD_antitoxin)	Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH	ParD is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is ParE in, Pfam:PF05016. The family contains several related antitoxins from Cyanobacteria, Proteobacteria and Actinobacteria. Antitoxins of this class carry an N-ter ...	ParD is the antitoxin of a bacterial toxin-antitoxin gene pair. The cognate toxin is ParE in, Pfam:PF05016. The family contains several related antitoxins from Cyanobacteria, Proteobacteria and Actinobacteria. Antitoxins of this class carry an N-terminal ribbon-helix-helix domain, RHH, that is highly conserved across all type II bacterial antitoxins, which dimerises with the RHH domain of a second VapB molecule. A hinge section follows the RHH, with an additional pair of flexible alpha helices at the C-terminus. This C-terminus is the toxin-binding region of the dimer, and so is specific to the cognate toxin, whereas the RHH domain has the specific function of lying across the RNA-binding groove of the toxin dimer and inactivating the active-site - a more general function of all type II antitoxins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Toxin protein parE-1	-	protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization	-
C, D	Antitoxin protein parD-1	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity	protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization regulation of cellular process cellular biosynthetic process RNA metabolic process protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR007712	Toxin-antitoxin system, RelE/ParE toxin family	Family
A, B	IPR028344	Toxin-antitoxin system, toxin component ParE1/4	Family
A, B	IPR035093	Toxin-antitoxin system, RelE/ParE toxin domain superfamily	Homologous Superfamily
C, D	IPR022789	Antitoxin ParD	Family
C, D	IPR038296	Antitoxin ParD superfamily	Homologous Superfamily
C, D	IPR010985	Ribbon-helix-helix	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.