3KO0

Structure of the tfp-ca2+-bound activated form of the s100a4 Metastasis factor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3ko0a_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3ko0b_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3ko0c_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3ko0d_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3ko0e_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d3ko0f_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d3ko0g_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d3ko0h_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d3ko0i_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d3ko0j_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d3ko0k_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d3ko0l_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d3ko0m_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d3ko0n_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
O	d3ko0o_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
P	d3ko0p_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
Q	d3ko0q_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
R	d3ko0r_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
S	d3ko0s_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
T	d3ko0t_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	EF-hand	8039698	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	S_100	e3ko0A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
B	S_100	e3ko0B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
C	S_100	e3ko0C1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
D	S_100	e3ko0D1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
E	S_100	e3ko0E1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
F	S_100	e3ko0F1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
G	S_100	e3ko0G1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
H	S_100	e3ko0H1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
I	S_100	e3ko0I1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
J	S_100	e3ko0J1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
K	S_100	e3ko0K1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
L	S_100	e3ko0L1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
M	S_100	e3ko0M1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
N	S_100	e3ko0N1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
O	S_100	e3ko0O1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
P	S_100	e3ko0P1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
Q	S_100	e3ko0Q1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
R	S_100	e3ko0R1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
S	S_100	e3ko0S1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
T	S_100	e3ko0T1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
D	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
E	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
F	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
G	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
H	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
I	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
J	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
K	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
L	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
M	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
N	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
O	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
P	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
Q	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
R	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
S	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
T	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	Protein S100-A4	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding RAGE receptor binding protein binding signaling receptor binding cytoskeletal protein binding actin binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity cation binding ion binding binding calcium ion binding metal ion binding small molecule binding RAGE receptor binding protein binding signaling receptor binding cytoskeletal protein binding actin binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity chemoattractant activity signaling receptor activator activity transition metal ion binding calcium-dependent protein binding RNA binding organic cyclic compound binding nucleic acid binding identical protein binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction cellular process positive regulation of signaling developmental process cellular developmental process cell differentiation animal organ development anatomical structure development mesenchyme development mesenchymal cell differentiation tissue development epithelial to mesenchymal transition	extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix extracellular region cellular anatomical entity extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol perinuclear region of cytoplasm nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR034325	S-100	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR002048	EF-hand domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	Pharos: P26447	medulloblastoma malignant colon neoplasm melanotic medulloblastoma intracranial vasospasm adult acute respiratory distress syndrome Neoplasm Invasiveness childhood medulloblastoma keloid adult medulloblastoma medullomyoblastoma with myogenic differentiation subependymal giant cell astrocytoma head and neck cancer limb-girdle muscular dystrophy lung carcinoma adrenoleukodystrophy medulloblastoma malignant colon neoplasm melanotic medulloblastoma intracranial vasospasm adult acute respiratory distress syndrome Neoplasm Invasiveness childhood medulloblastoma keloid adult medulloblastoma medullomyoblastoma with myogenic differentiation subependymal giant cell astrocytoma head and neck cancer limb-girdle muscular dystrophy lung carcinoma adrenoleukodystrophy malignant ependymoma Alzheimer disease malignant pancreatic neoplasm Becker muscular dystrophy nephrosclerosis osteoarthritis susceptibility 1 cystic fibrosis pancreatic ductal adenocarcinoma Duchenne muscular dystrophy pilocytic astrocytoma gastric carcinoma tuberculosis ischemic disease lung adenocarcinoma lymphoplasmacytic lymphoma malignant glioma amyotrophic lateral sclerosis benign colon neoplasm non-small cell lung carcinoma desmoplastic/nodular medulloblastoma pancreatic intraductal papillary-mucinous neoplasm ductal breast carcinoma in situ psoriasis glioblastoma ulcerative colitis invasive ductal breast carcinoma lung cancer malignant mesothelioma atypical teratoid rhabdoid tumor breast fibroadenoma osteoarthritis colonic neoplasm ovarian cancer diabetes mellitus Pick disease Emery-Dreifuss muscular dystrophy