3KFD

Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3kfda_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3kfdb_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth C]	d3kfdc_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth D]	d3kfdd_	Small proteins	Cystine-knot cytokines	Cystine-knot cytokines	Transforming growth factor (TGF)-beta	TGF-beta1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth E]	d3kfde_	Small proteins	Snake toxin-like	Snake toxin-like	Extracellular domain of cell surface receptors	TGF-beta type II receptor extracellular domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth F]	d3kfdf_	Small proteins	Snake toxin-like	Snake toxin-like	Extracellular domain of cell surface receptors	TGF-beta type II receptor extracellular domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth G]	d3kfdg_	Small proteins	Snake toxin-like	Snake toxin-like	Extracellular domain of cell surface receptors	TGF-beta type II receptor extracellular domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J [auth H]	d3kfdh_	Small proteins	Snake toxin-like	Snake toxin-like	Extracellular domain of cell surface receptors	TGF-beta type II receptor extracellular domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
H [auth D]	SCOP2B Superfamily	Cystine-knot cytokines	8038779	3000846	SCOP2B (2022-06-29)
C [auth E]	SCOP2B Superfamily	Snake toxin-like	8038457	3000545	SCOP2B (2022-06-29)
D [auth F]	SCOP2B Superfamily	Snake toxin-like	8038457	3000545	SCOP2B (2022-06-29)
I [auth G]	SCOP2B Superfamily	Snake toxin-like	8038457	3000545	SCOP2B (2022-06-29)
J [auth H]	SCOP2B Superfamily	Snake toxin-like	8038457	3000545	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00019	e3kfdA1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
B	PF00019	e3kfdB1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
G [auth C]	PF00019	e3kfdC1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
H [auth D]	PF00019	e3kfdD1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00019	ECOD (1.6)
C [auth E]	PF08917	e3kfdE1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF08917	ECOD (1.6)
D [auth F]	PF08917	e3kfdF1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF08917	ECOD (1.6)
I [auth G]	PF08917	e3kfdG1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF08917	ECOD (1.6)
J [auth H]	PF08917	e3kfdH1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF08917	ECOD (1.6)
E [auth I]	PF01064	e3kfdI1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF01064	ECOD (1.6)
F [auth J]	PF01064	e3kfdJ1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF01064	ECOD (1.6)
K	PF01064	e3kfdK1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF01064	ECOD (1.6)
L	PF01064	e3kfdL1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF01064	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
G [auth C]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
H [auth D]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
C [auth E]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
D [auth F]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
I [auth G]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
J [auth H]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
E [auth I]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
F [auth J]	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
K	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
L	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, G [auth C], H [auth D]	PF00019	Transforming growth factor beta like domain (TGF_beta)	Transforming growth factor beta like domain	-	Domain
C [auth E], D [auth F], I [auth G], J [auth H]	PF08917	Transforming growth factor beta receptor 2 ectodomain (ecTbetaR2)	Transforming growth factor beta receptor 2 ectodomain	The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antipar ...	The Transforming growth factor beta receptor 2 ectodomain is a compact fold consisting of nine beta-strands and a single helix stabilised by a network of six intra strand disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel beta-sheets (beta1-beta4, beta3-beta9) [1].	Domain
E [auth I], F [auth J], K, L	PF01064	Activin types I and II receptor domain (Activin_recp)	Activin types I and II receptor domain	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The t ...	This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, G [auth C], H [auth D]	Transforming growth factor beta-1	transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding antigen binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding antigen binding enzyme regulator activity enzyme activator activity peptidase regulator activity molecular function activator activity molecular function regulator activity deubiquitinase activator activity peptidase activator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity identical protein binding type II transforming growth factor beta receptor binding type III transforming growth factor beta receptor binding cytokine activity enzyme binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process multicellular organismal process gland development animal organ development salivary gland development anatomical structure morphogenesis multicellular organism development gland morphogenesis salivary gland morphogenesis anatomical structure development animal organ morphogenesis exocrine system development system development negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process positive regulation of post-transcriptional gene silencing nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process positive regulation of primary miRNA processing organic substance biosynthetic process positive regulation of post-transcriptional gene silencing by RNA positive regulation of macromolecule metabolic process RNA processing regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process primary metabolic process regulation of miRNA processing negative regulation of cellular biosynthetic process positive regulation of RNA metabolic process primary miRNA processing regulation of gene expression organic cyclic compound metabolic process miRNA-mediated post-transcriptional gene silencing negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process post-transcriptional gene silencing miRNA processing regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process RNA metabolic process positive regulation of cellular metabolic process regulation of miRNA-mediated gene silencing organic substance metabolic process positive regulation of miRNA-mediated gene silencing regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA positive regulation of biosynthetic process negative regulation of cellular process regulation of post-transcriptional gene silencing by regulatory ncRNA positive regulation of miRNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of primary miRNA processing regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of post-transcriptional gene silencing negative regulation of biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process reactive oxygen species metabolic process regulation of superoxide metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process superoxide anion generation positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of reactive oxygen species metabolic process heart development circulatory system development immune system development lymph node development immune system process hematopoietic or lymphoid organ development protein localization cellular localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport organic substance transport intracellular transport protein export from nucleus establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization nuclear export intracellular protein transport chemotaxis positive regulation of locomotion regulation of response to external stimulus response to external stimulus regulation of chemotaxis positive regulation of chemotaxis positive regulation of response to external stimulus taxis response to chemical regulation of locomotion locomotion regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation regulation of developmental process regulation of tissue remodeling regulation of blood vessel remodeling blood vessel remodeling tissue remodeling regulation of multicellular organismal process regulation of anatomical structure morphogenesis heart valve development heart valve morphogenesis DNA-templated transcription regulation of miRNA metabolic process miRNA metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process regulation of miRNA transcription cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation cell differentiation regulatory T cell differentiation T cell differentiation leukocyte differentiation regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion embryonic epithelial tube formation chordate embryonic development tube formation embryo development epithelial tube formation tube morphogenesis primary neural tube formation embryo development ending in birth or egg hatching epithelial tube morphogenesis morphogenesis of embryonic epithelium epithelium development neural tube development tube development embryonic morphogenesis morphogenesis of an epithelium nervous system development tissue development tissue morphogenesis neural tube closure neural tube formation anatomical structure formation involved in morphogenesis tube closure lymphocyte mediated immunity regulation of immune effector process immune response to tumor cell negative regulation of immune response to tumor cell negative regulation of lymphocyte mediated immunity response to biotic stimulus negative regulation of natural killer cell mediated immunity regulation of natural killer cell mediated cytotoxicity directed against tumor cell target leukocyte mediated immunity regulation of natural killer cell mediated immune response to tumor cell regulation of immune system process natural killer cell mediated immunity regulation of natural killer cell mediated immunity negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response response to other organism regulation of innate immune response negative regulation of immune response negative regulation of immune effector process leukocyte mediated cytotoxicity natural killer cell mediated immune response to tumor cell immune effector process regulation of leukocyte mediated immunity defense response to other organism negative regulation of response to external stimulus negative regulation of defense response natural killer cell mediated cytotoxicity regulation of immune response regulation of cell killing regulation of defense response negative regulation of natural killer cell mediated cytotoxicity regulation of response to biotic stimulus regulation of natural killer cell mediated cytotoxicity biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus negative regulation of response to tumor cell regulation of response to tumor cell response to stress regulation of response to stress innate immune response negative regulation of leukocyte mediated cytotoxicity response to external biotic stimulus negative regulation of cell killing response to tumor cell defense response negative regulation of response to stimulus regulation of leukocyte mediated cytotoxicity defense response to symbiont regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of natural killer cell mediated immune response to tumor cell regulation of lymphocyte mediated immunity negative regulation of immune system process negative regulation of leukocyte mediated immunity cell killing negative regulation of innate immune response response to wounding cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation regulation of vascular permeability system process circulatory system process positive regulation of vascular permeability vascular process in circulatory system regulation of biological quality blood circulation negative regulation of macrophage cytokine production cytokine production negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response negative regulation of production of molecular mediator of immune response regulation of macrophage cytokine production regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of cytokine production myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response negative regulation of cytokine production macrophage cytokine production ribose phosphate metabolic process ATP metabolic process ATP biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process purine ribonucleoside triphosphate biosynthetic process ribonucleotide biosynthetic process purine nucleotide metabolic process ribonucleotide metabolic process purine nucleoside triphosphate biosynthetic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process small molecule metabolic process ribose phosphate biosynthetic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process carbohydrate derivative biosynthetic process purine nucleoside triphosphate metabolic process nucleoside triphosphate biosynthetic process nucleotide metabolic process ribonucleoside triphosphate biosynthetic process purine-containing compound metabolic process organophosphate metabolic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process connective tissue development skeletal system development chondrocyte differentiation cartilage development organonitrogen compound catabolic process mucopolysaccharide metabolic process carbohydrate derivative catabolic process catabolic process hyaluronan catabolic process glycosaminoglycan metabolic process aminoglycan catabolic process macromolecule catabolic process glycosaminoglycan catabolic process hyaluronan metabolic process aminoglycan metabolic process organic substance catabolic process cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription negative regulation of RNA metabolic process fat cell differentiation negative regulation of developmental process regulation of cell differentiation negative regulation of fat cell differentiation negative regulation of cell differentiation regulation of fat cell differentiation positive regulation of protein metabolic process positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT regulation of receptor signaling pathway via STAT regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition mesenchyme development positive regulation of developmental process positive regulation of cell differentiation epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation regulation of cellular component organization positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization extracellular matrix organization regulation of cellular component biogenesis cellular component organization cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly cellular component organization or biogenesis regulation of extracellular matrix organization extracellular matrix assembly extracellular structure organization external encapsulating structure organization regulation of muscle tissue development skeletal muscle tissue development negative regulation of muscle tissue development regulation of skeletal muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development negative regulation of skeletal muscle tissue development aortic valve development semi-lunar valve development aortic valve morphogenesis negative regulation of miRNA transcription negative regulation of miRNA metabolic process membrane protein intracellular domain proteolysis proteolysis membrane protein proteolysis regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration cell migration cell motility regulation of epithelial cell migration positive regulation of blood vessel endothelial cell migration epithelium migration positive regulation of endothelial cell migration regulation of striated muscle cell differentiation regulation of cardiac muscle cell differentiation muscle cell differentiation striated muscle tissue development positive regulation of cardiocyte differentiation positive regulation of striated muscle cell differentiation positive regulation of cardiac muscle cell differentiation cardiac muscle tissue development cardiac muscle cell differentiation positive regulation of muscle cell differentiation cardiocyte differentiation regulation of muscle cell differentiation regulation of cardiocyte differentiation striated muscle cell differentiation blood vessel morphogenesis vasculogenesis vasculature development blood vessel development embryonic organ development embryonic liver development positive regulation of epithelial cell apoptotic process positive regulation of endothelial cell apoptotic process positive regulation of programmed cell death regulation of epithelial cell apoptotic process regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production positive regulation of cytokine production myofibroblast differentiation regulation of leukocyte differentiation positive regulation of nervous system development regulation of neurogenesis regulation of cell development positive regulation of gliogenesis gliogenesis microglia differentiation regulation of macrophage differentiation positive regulation of immune system process regulation of microglia differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation positive regulation of macrophage differentiation central nervous system development positive regulation of microglia differentiation myeloid leukocyte differentiation regulation of gliogenesis regulation of nervous system development neurogenesis positive regulation of hemopoiesis positive regulation of neurogenesis regulation of multicellular organismal development regulation of myeloid cell differentiation macrophage differentiation regulation of glial cell differentiation positive regulation of glial cell differentiation glial cell differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway positive regulation of Wnt signaling pathway Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of Wnt signaling pathway regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to organic substance response to lipid response to estradiol response to oxygen-containing compound response to organic cyclic compound positive regulation of phosphorylation peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process regulation of peptidyl-tyrosine phosphorylation peptidyl-tyrosine phosphorylation regulation of localization regulation of protein localization regulation of protein localization to nucleus import into nucleus regulation of protein import into nucleus protein import into nucleus regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of protein localization to organelle regulation of cellular localization protein localization to organelle regulation of intracellular protein transport regulation of inflammatory response positive regulation of inflammatory response positive regulation of defense response inflammatory response response to ketone response to progesterone response to hormone response to steroid hormone response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to oxygen levels response to abiotic stimulus protein-containing complex organization positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly protein-containing complex assembly negative regulation of cell cycle cell cycle regulation of cell cycle response to sterol response to alcohol response to cholesterol regulation of growth growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth extrinsic apoptotic signaling pathway apoptotic signaling pathway cell surface receptor protein tyrosine kinase signaling pathway positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway angiogenesis sprouting angiogenesis positive regulation of cell division cell division regulation of cell division positive regulation of establishment of protein localization positive regulation of protein localization to nucleus positive regulation of protein import into nucleus positive regulation of protein localization positive regulation of intracellular protein transport positive regulation of nucleocytoplasmic transport positive regulation of protein transport positive regulation of intracellular transport positive regulation of transport chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production regulation of chemokine production chemokine production positive regulation of chemokine production mesenchymal stem cell proliferation regulation of stem cell proliferation positive regulation of mesenchymal stem cell proliferation regulation of mesenchymal stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation negative regulation of locomotion negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration negative regulation of epithelial cell migration negative regulation of cell migration negative regulation of cell motility response to organonitrogen compound response to lipoprotein particle response to nitrogen compound cellular response to low-density lipoprotein particle stimulus cellular response to lipoprotein particle stimulus cellular component disassembly negative regulation of extracellular matrix organization extracellular matrix disassembly negative regulation of cellular component organization negative regulation of extracellular matrix disassembly regulation of extracellular matrix disassembly negative regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation ventricular cardiac muscle tissue morphogenesis heart morphogenesis ventricular cardiac muscle tissue development cardiac chamber development cardiac chamber morphogenesis muscle tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis cardiac ventricle development muscle organ morphogenesis collagen biosynthetic process regulation of collagen biosynthetic process regulation of collagen metabolic process positive regulation of collagen metabolic process positive regulation of collagen biosynthetic process collagen metabolic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II receptor catabolic process cellular catabolic process receptor metabolic process regulation of striated muscle tissue development regulation of muscle organ development negative regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of protein localization protein localization to cell periphery protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane negative regulation of protein localization to membrane negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane regulation of vascular endothelial growth factor production vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production negative regulation of myoblast differentiation regulation of myoblast differentiation myoblast differentiation regulation of fibroblast migration positive regulation of fibroblast migration fibroblast migration wound healing connective tissue replacement involved in inflammatory response wound healing wound healing involved in inflammatory response inflammatory response to wounding connective tissue replacement regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of vasculature development positive regulation of vasculature development positive regulation of secretion by cell protein localization to extracellular region regulation of secretion by cell secretion by cell positive regulation of secretion secretion establishment of protein localization to extracellular region export from cell protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion epithelial cell differentiation neuroepithelial cell differentiation odontoblast differentiation columnar/cuboidal epithelial cell differentiation negative regulation of biomineral tissue development regulation of biomineral tissue development biomineral tissue development protein dephosphorylation positive regulation of dephosphorylation regulation of dephosphorylation regulation of protein dephosphorylation dephosphorylation positive regulation of protein dephosphorylation foam cell differentiation macrophage derived foam cell differentiation hematopoietic progenitor cell differentiation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of immune response positive regulation of isotype switching to IgA isotypes positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response DNA recombination DNA metabolic process positive regulation of DNA metabolic process B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of DNA metabolic process immunoglobulin production positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of immunoglobulin production regulation of isotype switching isotype switching to IgA isotypes somatic diversification of immune receptors via germline recombination within a single locus regulation of lymphocyte activation regulation of DNA recombination positive regulation of leukocyte mediated immunity cell activation involved in immune response positive regulation of cell activation positive regulation of leukocyte activation somatic diversification of immune receptors positive regulation of adaptive immune response somatic recombination of immunoglobulin genes involved in immune response regulation of adaptive immune response regulation of B cell mediated immunity somatic diversification of immunoglobulins isotype switching immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity regulation of isotype switching to IgA isotypes positive regulation of B cell mediated immunity regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains lymphocyte activation involved in immune response B cell activation immunoglobulin mediated immune response adaptive immune response positive regulation of B cell activation regulation of immunoglobulin production glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process carbohydrate biosynthetic process hyaluronan biosynthetic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process polysaccharide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process polysaccharide biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process cell junction organization cell-cell junction organization	extracellular region extracellular space cellular anatomical entity cell surface cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle lumen extracellular region extracellular space cellular anatomical entity cell surface cell periphery plasma membrane membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm membrane-bounded organelle vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle organelle lumen organelle secretory granule secretory vesicle platelet alpha granule vesicle platelet alpha granule lumen Golgi apparatus Golgi lumen blood microparticle nucleus
C [auth E], D [auth F], I [auth G], J [auth H]	TGF-beta receptor type-2	protein serine/threonine kinase activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity protein serine/threonine kinase activity molecular transducer activity catalytic activity, acting on a protein kinase activity protein kinase activity signaling receptor activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups transmembrane receptor protein serine/threonine kinase activity transforming growth factor beta receptor activity, type II transmembrane receptor protein kinase activity transmembrane signaling receptor activity catalytic activity transforming growth factor beta receptor activity transforming growth factor beta receptor binding protein binding binding signaling receptor binding type I transforming growth factor beta receptor binding cytokine receptor binding protein-containing complex binding activin binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding activin receptor activity molecular adaptor activity cation binding metal ion binding transforming growth factor beta binding growth factor binding cytokine binding type III transforming growth factor beta receptor binding SMAD binding glycosaminoglycan binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling response to chemical response to xenobiotic stimulus developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development heart development circulatory system development cardiac chamber morphogenesis heart morphogenesis ventricular septum development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development regulation of developmental process cellular developmental process regulation of cell differentiation stem cell differentiation cell differentiation regulation of stem cell differentiation sensory organ development eye development visual system development camera-type eye development sensory system development lens development in camera-type eye regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process apoptotic process cell death programmed cell death response to organic substance response to sterol response to lipid response to alcohol response to oxygen-containing compound response to cholesterol response to organic cyclic compound membranous septum morphogenesis bronchus development tube development respiratory tube development tube morphogenesis respiratory system development bronchus morphogenesis epithelial cell apoptotic process lens fiber cell apoptotic process blood vessel morphogenesis artery development vasculature development artery morphogenesis blood vessel development positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity organonitrogen compound metabolic process positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development outflow tract septum morphogenesis outflow tract morphogenesis hemopoiesis cell development embryonic hemopoiesis embryonic organ development branching morphogenesis of an epithelial tube angiogenesis epithelial tube morphogenesis epithelium development morphogenesis of an epithelium tissue development branching involved in blood vessel morphogenesis tissue morphogenesis morphogenesis of a branching structure anatomical structure formation involved in morphogenesis morphogenesis of a branching epithelium secondary palate development roof of mouth development mesenchyme development mesenchymal cell differentiation epithelial to mesenchymal transition positive regulation of cell population proliferation regulation of leukocyte activation regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell proliferation regulation of cell activation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of cell activation T cell activation alpha-beta T cell proliferation lymphocyte proliferation positive regulation of leukocyte activation alpha-beta T cell activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of alpha-beta T cell activation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of alpha-beta T cell proliferation positive regulation of lymphocyte activation positive regulation of CD4-positive, alpha-beta T cell activation cell adhesion cell-cell adhesion CD4-positive, alpha-beta T cell activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation CD4-positive, alpha-beta T cell proliferation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of T cell proliferation regulation of CD4-positive, alpha-beta T cell activation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation immune system development regulation of B cell tolerance induction B cell tolerance induction positive regulation of B cell tolerance induction regulation of tolerance induction positive regulation of tolerance induction tolerance induction mesenchyme morphogenesis endocardial cushion morphogenesis endocardial cushion development inferior endocardial cushion morphogenesis Notch signaling pathway pattern specification process embryonic heart tube development embryonic heart tube morphogenesis heart looping determination of bilateral symmetry determination of left/right symmetry specification of symmetry embryonic organ morphogenesis embryonic morphogenesis determination of heart left/right asymmetry regionalization left/right pattern formation cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway cell-cell adhesion via plasma-membrane adhesion molecules endocardial cushion fusion cell adhesion involved in heart morphogenesis smoothened signaling pathway myeloid leukocyte differentiation myeloid dendritic cell activation mononuclear cell differentiation myeloid leukocyte activation myeloid cell differentiation myeloid dendritic cell differentiation dendritic cell differentiation leukocyte differentiation lung lobe morphogenesis lung lobe development lung development lung morphogenesis aorta morphogenesis aorta development regulation of epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition positive regulation of developmental process positive regulation of cell differentiation embryonic cranial skeleton morphogenesis skeletal system development cranial skeletal system development embryonic skeletal system development skeletal system morphogenesis embryonic skeletal system morphogenesis gastrulation positive regulation of mesenchymal cell proliferation regulation of mesenchymal cell proliferation mesenchymal cell proliferation atrioventricular valve development heart valve development tricuspid valve development heart valve morphogenesis tricuspid valve morphogenesis atrioventricular valve morphogenesis trachea morphogenesis trachea formation trachea development animal organ formation T cell tolerance induction positive regulation of T cell tolerance induction regulation of T cell tolerance induction reactive oxygen species metabolic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process regulation of tolerance induction to self antigen tolerance induction to self antigen positive regulation of tolerance induction to self antigen aortic valve development semi-lunar valve development aortic valve morphogenesis connective tissue development developmental growth endochondral bone morphogenesis organ growth cell growth growth plate cartilage chondrocyte development chondrocyte differentiation involved in endochondral bone morphogenesis growth plate cartilage development endochondral bone growth growth plate cartilage chondrocyte growth bone development developmental cell growth chondrocyte hypertrophy growth chondrocyte development involved in endochondral bone morphogenesis developmental growth involved in morphogenesis growth plate cartilage chondrocyte differentiation bone growth chondrocyte differentiation cartilage development involved in endochondral bone morphogenesis bone morphogenesis chondrocyte development cartilage development regulation of stem cell proliferation stem cell proliferation cardiac ventricle morphogenesis cardiac left ventricle morphogenesis gland morphogenesis mammary gland morphogenesis mammary gland development gland development positive regulation of cardiac epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation regulation of cardiac epithelial to mesenchymal transition endocardial cushion formation regulation of epithelial to mesenchymal transition involved in endocardial cushion formation RNA transport nitrogen compound transport transport organic substance transport nucleic acid transport establishment of localization localization establishment of RNA localization miRNA transport macromolecule localization RNA localization nucleobase-containing compound transport Langerhans cell differentiation vasculogenesis regulation of vasculature development regulation of anatomical structure morphogenesis regulation of multicellular organismal development positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis regulation of leukocyte differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development T cell differentiation positive regulation of cell development positive regulation of alpha-beta T cell differentiation positive regulation of NK T cell differentiation regulation of alpha-beta T cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation positive regulation of hemopoiesis NK T cell differentiation regulation of lymphocyte differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation regulation of NK T cell differentiation positive regulation of lymphocyte differentiation positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration cell migration epithelial cell migration cell motility regulation of epithelial cell migration locomotion epithelium migration regulation of locomotion	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex receptor complex extracellular region extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm cytosol protein-containing complex receptor complex extracellular region extracellular space membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola catalytic complex plasma membrane protein complex membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups serine/threonine protein kinase complex transforming growth factor beta ligand-receptor complex plasma membrane signaling receptor complex
E [auth I], F [auth J], K, L	TGF-beta receptor type-1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ubiquitin protein ligase binding protein binding ubiquitin-like protein ligase binding enzyme binding cation binding metal ion binding transforming growth factor beta binding growth factor binding cytokine binding SMAD binding protein serine/threonine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups molecular transducer activity signaling receptor activity transmembrane receptor protein serine/threonine kinase activity transmembrane receptor protein kinase activity transmembrane signaling receptor activity transforming growth factor beta receptor activity, type I transforming growth factor beta receptor activity activin receptor activity activin receptor activity, type I protein-containing complex binding activin binding I-SMAD binding transforming growth factor beta receptor binding type II transforming growth factor beta receptor binding signaling receptor binding cytokine receptor binding	cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway biological regulation positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development cardiac chamber morphogenesis heart morphogenesis ventricular septum development anatomical structure morphogenesis cardiac septum development cardiac septum morphogenesis ventricular septum morphogenesis cardiac chamber development animal organ morphogenesis cardiac ventricle development cellular component organization cellular component organization or biogenesis extracellular structure organization regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway sensory organ development eye development visual system development camera-type eye development sensory system development lens development in camera-type eye epithelium migration tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility blood vessel morphogenesis tube development artery development vasculature development tube morphogenesis artery morphogenesis blood vessel development angiogenesis involved in coronary vascular morphogenesis coronary vasculature development angiogenesis anatomical structure formation involved in morphogenesis coronary vasculature morphogenesis cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process negative regulation of locomotion regulation of cell motility negative regulation of biological process regulation of locomotion negative regulation of cellular process regulation of cell migration negative regulation of cell motility negative regulation of cell migration locomotion nervous system development skeletal system development skeletal system morphogenesis endocrine system development gland development parathyroid gland development negative regulation of signaling extrinsic apoptotic signaling pathway negative regulation of cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic process cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway ventricular cardiac muscle tissue morphogenesis striated muscle tissue development muscle structure development ventricular cardiac muscle tissue development ventricular trabecula myocardium morphogenesis muscle tissue development muscle organ development cardiac muscle tissue development tissue development muscle tissue morphogenesis tissue morphogenesis cardiac ventricle morphogenesis cardiac muscle tissue morphogenesis heart trabecula morphogenesis trabecula morphogenesis muscle organ morphogenesis cell population proliferation endothelial cell proliferation epithelial cell proliferation regulation of growth regulation of cellular component organization growth positive regulation of cell growth regulation of cell growth cell growth positive regulation of growth sexual reproduction reproductive process multicellular organismal reproductive process germ cell migration gamete generation regulation of epithelial to mesenchymal transition regulation of developmental process cellular developmental process positive regulation of epithelial to mesenchymal transition regulation of cell differentiation mesenchyme development positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of multicellular organismal process epithelial to mesenchymal transition positive regulation of multicellular organismal process mesenchymal cell differentiation positive regulation of cellular component organization positive regulation of cellular component biogenesis positive regulation of extracellular matrix organization extracellular matrix organization regulation of cellular component biogenesis cellular component biogenesis cellular component assembly regulation of extracellular matrix assembly positive regulation of extracellular matrix assembly regulation of extracellular matrix organization extracellular matrix assembly external encapsulating structure organization activin receptor signaling pathway epicardium morphogenesis positive regulation of cell population proliferation regulation of cell population proliferation positive regulation of cardiac epithelial to mesenchymal transition positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation endocardial cushion morphogenesis endocardial cushion development cardiac epithelial to mesenchymal transition epithelial to mesenchymal transition involved in endocardial cushion formation regulation of cardiac epithelial to mesenchymal transition mesenchyme morphogenesis endocardial cushion formation regulation of epithelial to mesenchymal transition involved in endocardial cushion formation positive regulation of locomotion positive regulation of cell migration positive regulation of cell motility organonitrogen compound metabolic process regulation of protein modification process regulation of post-translational protein modification regulation of protein metabolic process regulation of protein ubiquitination protein ubiquitination macromolecule modification protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal wound healing response to stress response to wounding filopodium assembly cell projection organization regulation of filopodium assembly plasma membrane bounded cell projection assembly positive regulation of cell projection organization positive regulation of filopodium assembly plasma membrane bounded cell projection organization regulation of cell projection organization regulation of cell projection assembly regulation of plasma membrane bounded cell projection assembly cell projection assembly regulation of plasma membrane bounded cell projection organization positive regulation of plasma membrane bounded cell projection assembly myofibroblast differentiation regulation of cartilage development regulation of chondrocyte differentiation connective tissue development negative regulation of cartilage development negative regulation of chondrocyte differentiation negative regulation of cell differentiation regulation of multicellular organismal development negative regulation of developmental process chondrocyte differentiation negative regulation of multicellular organismal process cartilage development positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation regulation of cardiac muscle tissue growth developmental growth cardiac muscle cell proliferation organ growth regulation of organ growth regulation of heart growth regulation of cardiac muscle cell proliferation muscle cell proliferation cardiac muscle tissue growth striated muscle cell proliferation heart growth regulation of developmental growth negative regulation of cell population proliferation negative regulation of endothelial cell proliferation negative regulation of epithelial cell proliferation positive regulation of organelle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cytoskeleton organization actin filament organization positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization gonad development reproductive system development sex differentiation developmental process involved in reproduction male gonad development male sex differentiation development of primary male sexual characteristics development of primary sexual characteristics reproductive structure development positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process response to organic substance response to sterol response to lipid response to alcohol response to chemical response to oxygen-containing compound response to cholesterol response to organic cyclic compound embryo development ending in birth or egg hatching pharyngeal system development chordate embryonic development embryo development collagen fibril organization in utero embryonic development mesenchymal stem cell proliferation regulation of stem cell proliferation positive regulation of mesenchymal stem cell proliferation regulation of mesenchymal stem cell proliferation positive regulation of stem cell proliferation stem cell proliferation cellular component disassembly regulation of tight junction disassembly cell junction disassembly tight junction organization positive regulation of tight junction disassembly tight junction disassembly cell junction organization cell-cell junction disassembly cell-cell junction organization protein phosphorylation phosphorylation peptidyl-serine modification peptidyl-serine phosphorylation peptidyl-amino acid modification phosphate-containing compound metabolic process phosphorus metabolic process kidney development renal system development immune system development hematopoietic or lymphoid organ development thymus development immune system process embryonic organ morphogenesis embryonic cranial skeleton morphogenesis embryonic morphogenesis cranial skeletal system development embryonic skeletal system development embryonic organ development embryonic skeletal system morphogenesis regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron fate commitment generation of neurons neurogenesis neuron differentiation cell fate commitment coronary artery morphogenesis regulation of vasculature development positive regulation of vasculature development positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process cell cycle regulation of cell cycle ventricular compact myocardium morphogenesis blastocyst development post-embryonic development anterior/posterior pattern specification pattern specification process regionalization roof of mouth development endothelial cell activation cell activation	protein-containing complex receptor complex cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle protein-containing complex receptor complex cell surface cellular anatomical entity cell periphery plasma membrane membrane membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure endosome intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle catalytic complex plasma membrane protein complex membrane protein complex transferase complex protein kinase complex transferase complex, transferring phosphorus-containing groups serine/threonine protein kinase complex transforming growth factor beta ligand-receptor complex plasma membrane signaling receptor complex activin receptor complex cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction cell junction nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, G [auth C], H [auth D]	IPR003939	Transforming growth factor beta-1 proprotein	Family
A, B, G [auth C], H [auth D]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, B, G [auth C], H [auth D]	IPR017948	Transforming growth factor beta, conserved site	Conserved Site
A, B, G [auth C], H [auth D]	IPR001839	Transforming growth factor-beta, C-terminal	Domain
A, B, G [auth C], H [auth D]	IPR016319	Transforming growth factor-beta	Family
A, B, G [auth C], H [auth D]	IPR015615	Transforming growth factor-beta-related	Family
A, B, G [auth C], H [auth D]	IPR001111	TGF-beta, propeptide	Domain
C [auth E], D [auth F], I [auth G], J [auth H]	IPR000719	Protein kinase domain	Domain
C [auth E], D [auth F], I [auth G], J [auth H]	IPR000333	Ser/Thr protein kinase, TGFB receptor	Family
C [auth E], D [auth F], I [auth G], J [auth H]	IPR017194	Transforming growth factor-beta receptor, type II	Family
C [auth E], D [auth F], I [auth G], J [auth H]	IPR017441	Protein kinase, ATP binding site	Binding Site
C [auth E], D [auth F], I [auth G], J [auth H]	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
C [auth E], D [auth F], I [auth G], J [auth H]	IPR015013	Transforming growth factor beta receptor 2 ectodomain	Domain
C [auth E], D [auth F], I [auth G], J [auth H]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
C [auth E], D [auth F], I [auth G], J [auth H]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
C [auth E], D [auth F], I [auth G], J [auth H]	IPR008271	Serine/threonine-protein kinase, active site	Active Site
E [auth I], F [auth J], K, L	IPR000472	Activin types I and II receptor domain	Domain
E [auth I], F [auth J], K, L	IPR000719	Protein kinase domain	Domain
E [auth I], F [auth J], K, L	IPR003605	GS domain	Domain
E [auth I], F [auth J], K, L	IPR017441	Protein kinase, ATP binding site	Binding Site
E [auth I], F [auth J], K, L	IPR008271	Serine/threonine-protein kinase, active site	Active Site
E [auth I], F [auth J], K, L	IPR000333	Ser/Thr protein kinase, TGFB receptor	Family
E [auth I], F [auth J], K, L	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
E [auth I], F [auth J], K, L	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, G [auth C], H [auth D]	Pharos: P01137	Camurati-Engelmann disease sarcoidosis cystic fibrosis essential thrombocythemia kidney disease pneumonia duodenal ulcer aortic valve insufficiency cleft palate myocardial infarction IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma Camurati-Engelmann disease sarcoidosis cystic fibrosis essential thrombocythemia kidney disease pneumonia duodenal ulcer aortic valve insufficiency cleft palate myocardial infarction IgA glomerulonephritis nephrotic syndrome autoimmune hepatitis osteoporosis squamous cell carcinoma myopathy asthma oral submucous fibrosis calcinosis Duchenne muscular dystrophy endomyocardial fibrosis colorectal cancer Inflammation non-alcoholic fatty liver disease extrahepatic cholestasis occupational asthma osteoarthritis focal segmental glomerulosclerosis diabetic neuropathy Peyronie disease chronic kidney disease tubular adenocarcinoma dry eye syndrome allergic disease posterior leukoencephalopathy syndrome hypertensive disorder ureteral obstruction epilepsy proteinuria inflammatory bowel disease pulmonary emphysema brain disease granular cell carcinoma carcinosarcoma skin cancer diabetic autonomic neuropathy acute lung injury diabetic polyneuropathy hyperplasia urticaria prostate cancer intervertebral disc degenerative disorder pulmonary fibrosis sarcomatoid carcinoma carcinoma acromicric dysplasia skin neoplasm papilloma squamous papilloma adenocarcinoma chronic beryllium disease malignant pancreatic neoplasm alcoholic liver cirrhosis pleural disease chronic obstructive pulmonary disease type 2 diabetes mellitus cirrhosis of liver uremia postmenopausal osteoporosis congenital diaphragmatic hernia Becker muscular dystrophy cribriform carcinoma bipolar disorder schizophrenia depressive disorder glioblastoma lung disease pancreatic ductal adenocarcinoma malignant ependymoma papillomatosis hepatitis maturity-onset diabetes of the young ulcerative colitis primary biliary cholangitis colorectal carcinoma cribriform carcinoma of breast gastric carcinoma cancer lung benign neoplasm osteosarcoma acute kidney failure pancreatic neoplasm heart disease malignant glioma pilocytic astrocytoma medulloblastoma Duchenne and Becker muscular dystrophy pneumonitis undifferentiated carcinoma muscle tissue disease idiopathic interstitial pneumonia atypical teratoid rhabdoid tumor corneal dystrophy geleophysic dysplasia lung carcinoma diabetes mellitus diabetic kidney disease cerebrovascular disorder malignant mesothelioma hepatocellular carcinoma muscular disease astrocytic tumor idiopathic pulmonary fibrosis
C [auth E], D [auth F], I [auth G], J [auth H]	Pharos: P37173	Loeys-Dietz syndrome thoracic aortic aneurysm Lynch syndrome aortic aneurysm Marfan syndrome colorectal cancer, hereditary nonpolyposis, type 6 Loeys-Dietz syndrome 2 esophageal cancer Aneurysm, Dissecting gastrointestinal stromal tumor bone disease sarcomatoid carcinoma carcinoma craniosynostosis breast carcinoma Loeys-Dietz syndrome thoracic aortic aneurysm Lynch syndrome aortic aneurysm Marfan syndrome colorectal cancer, hereditary nonpolyposis, type 6 Loeys-Dietz syndrome 2 esophageal cancer Aneurysm, Dissecting gastrointestinal stromal tumor bone disease sarcomatoid carcinoma carcinoma craniosynostosis breast carcinoma malignant colon neoplasm prostate cancer familial thoracic aortic aneurysm and aortic dissection malignant ependymoma cancer ulcerative colitis chronic obstructive pulmonary disease medulloblastoma colorectal cancer dermatomyositis invasive ductal breast carcinoma nephrosclerosis limb-girdle muscular dystrophy arthrogryposis osteosarcoma ductal breast carcinoma in situ pilocytic astrocytoma lung benign neoplasm brain cancer esophagus carcinoma in situ breast cancer malignant glioma gastric adenocarcinoma cerebrovascular disorder undifferentiated carcinoma Gaucher disease colon carcinoma neoplasm of esophagus diabetic kidney disease juvenile dermatomyositis Becker muscular dystrophy benign neoplasm of esophagus ovarian cancer Ehlers-Danlos syndrome bone fracture lung cancer lymphoplasmacytic lymphoma schizophrenia malignant mesothelioma carcinoma of esophagus MALT lymphoma glioblastoma colonic neoplasm migraine disorder adrenal cortex carcinoma myopathy cystic fibrosis intellectual disability benign colon neoplasm non-small cell lung carcinoma Duchenne muscular dystrophy bone cancer pancreatic ductal adenocarcinoma Emery-Dreifuss muscular dystrophy lung adenocarcinoma esophageal squamous cell carcinoma lung carcinoma
E [auth I], F [auth J], K, L	Pharos: P36897	Loeys-Dietz syndrome thoracic aortic aneurysm craniosynostosis Aneurysm, Dissecting multiple self-healing squamous epithelioma skin cancer Loeys-Dietz syndrome 1 skin neoplasm cirrhosis of liver uremia colorectal cancer pilocytic astrocytoma familial thoracic aortic aneurysm and aortic dissection Gaucher disease wet macular degeneration Loeys-Dietz syndrome thoracic aortic aneurysm craniosynostosis Aneurysm, Dissecting multiple self-healing squamous epithelioma skin cancer Loeys-Dietz syndrome 1 skin neoplasm cirrhosis of liver uremia colorectal cancer pilocytic astrocytoma familial thoracic aortic aneurysm and aortic dissection Gaucher disease wet macular degeneration large cell medulloblastoma allergic rhinitis arthrogryposis malignant glioma cancer medulloblastoma colorectal carcinoma myopathy ovarian cancer primitive neuroectodermal tumor drug-induced liver injury ulcerative colitis glioblastoma intellectual disability astrocytic tumor cerebrovascular disorder malignant pancreatic neoplasm oligodendroglioma Crohn disease pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia prostate cancer Ehlers-Danlos syndrome juvenile dermatomyositis age-related macular degeneration aortic aneurysm malignant ependymoma breast cancer Marfan syndrome osteosarcoma