3KF9

Crystal structure of the SdCen/skMLCK complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3kf9a_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	automated matches	(Scherffelia dubia ) [TaxId: 3190 ],	SCOPe (2.08)
C	d3kf9c_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	automated matches	(Scherffelia dubia ) [TaxId: 3190 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00036	e3kf9A1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
A	PF13499	e3kf9A2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
C	PF00036	e3kf9C1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
C	PF13499	e3kf9C2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
C	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Caltractin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	cellular process cell cycle cell division	intracellular organelle microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle
B, D	Myosin light chain kinase 2, skeletal/cardiac muscle	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity catalytic activity, acting on a protein calmodulin-dependent protein kinase activity kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups myosin light chain kinase activity protein binding calmodulin binding cytoskeletal protein binding myosin light chain binding myosin binding	multicellular organismal process system process muscle contraction muscle system process striated muscle contraction skeletal muscle cell differentiation developmental process cellular developmental process skeletal muscle tissue development animal organ development tissue development muscle structure development skeletal muscle organ development cell differentiation multicellular organismal process system process muscle contraction muscle system process striated muscle contraction skeletal muscle cell differentiation developmental process cellular developmental process skeletal muscle tissue development animal organ development tissue development muscle structure development skeletal muscle organ development cell differentiation anatomical structure development cellular process muscle tissue development muscle organ development skeletal muscle satellite cell differentiation heart development cardiac muscle tissue development heart morphogenesis muscle tissue morphogenesis striated muscle tissue development circulatory system development multicellular organism development anatomical structure morphogenesis tissue morphogenesis cardiac muscle tissue morphogenesis animal organ morphogenesis muscle organ morphogenesis system development regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process heart process circulatory system process cardiac muscle contraction heart contraction blood circulation organonitrogen compound metabolic process protein phosphorylation phosphorylation primary metabolic process macromolecule modification peptidyl-amino acid modification phosphate-containing compound metabolic process peptidyl-threonine modification protein metabolic process protein modification process phosphorus metabolic process peptidyl-threonine phosphorylation trans-synaptic signaling signaling cell-cell signaling chemical synaptic transmission cell communication synaptic signaling anterograde trans-synaptic signaling neuromuscular synaptic transmission protein autophosphorylation regulation of localization cellular localization regulation of actin filament-based process transport muscle filament sliding regulation of system process localization establishment of localization in cell actin filament-based process regulation of multicellular organismal process regulation of intracellular transport actin-myosin filament sliding regulation of transport intracellular transport actin filament-based movement regulation of muscle system process establishment of localization regulation of muscle contraction regulation of cellular localization regulation of actin filament-based movement regulation of muscle filament sliding actin-mediated cell contraction	intracellular anatomical structure cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle synapse intracellular anatomical structure cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle synapse cell junction membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, C	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site	Conserved Site
A, C	IPR002048	EF-hand domain	Domain
A, C	IPR011992	EF-hand domain pair	Homologous Superfamily
B, D	IPR017441	Protein kinase, ATP binding site	Binding Site
B, D	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
B, D	IPR000719	Protein kinase domain	Domain
B, D	IPR042717	Myosin light chain kinase 2, catalytic domain	Domain
B, D	IPR008271	Serine/threonine-protein kinase, active site	Active Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, D	Pharos: Q9H1R3	cardiomyopathy hypertrophic cardiomyopathy 1 Asymmetric Septal Hypertrophy hypertrophic cardiomyopathy myopathy psoriasis Duchenne muscular dystrophy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.