3KE6

The crystal structure of the RsbU and RsbW domains of Rv1364c from Mycobacterium tuberculosis

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Histidine kinase	8091327	4001957	SCOP2 (2022-06-29)
A	SCOP2 Family	SpoIIE-like	8049206	4006401	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GHKL (Gyrase Hsp90 Histidine Kinase MutL) domain-like	8091328	3000091	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	PP2C-like	8091325	3000909	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	GHKL (Gyrase Hsp90 Histidine Kinase MutL) domain-like	8091328	3000091	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PP2C-like	8091325	3000909	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HATPase_c_2	e3ke6A3	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c_2	ECOD (1.6)
A	SpoIIE	e3ke6A4	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: SpoIIE	ECOD (1.6)
B	HATPase_c_2	e3ke6B2	A: a+b two layers	X: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like	H: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase (From Topology)	T: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase	F: HATPase_c_2	ECOD (1.6)
B	SpoIIE	e3ke6B1	A: a+b four layers	X: Ntn/PP2C	H: Protein serine/threonine phosphatase 2C, catalytic domain (From Topology)	T: Protein serine/threonine phosphatase 2C, catalytic domain	F: SpoIIE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.40.10	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)
A	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)
B	3.60.40.10	Alpha Beta	4-Layer Sandwich	Phosphatase 2c	domain 1	CATH (4.3.0)
B	3.30.565.10	Alpha Beta	2-Layer Sandwich	Heat Shock Protein 90	Histidine kinase-like ATPase, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF07228	Stage II sporulation protein E (SpoIIE) (SpoIIE)	Stage II sporulation protein E (SpoIIE)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein Rv1364c/MT1410	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds myosin phosphatase activity phosphatase activity hydrolase activity catalytic activity protein serine/threonine kinase activity kinase activity protein kinase activity transferase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups manganese ion binding transition metal ion binding identical protein binding protein binding alkaline phosphatase activity	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036457	PPM-type phosphatase-like domain superfamily	Homologous Superfamily
A, B	IPR000014	PAS domain	Domain
A, B	IPR013656	PAS fold-4	Domain
A, B	IPR003594	Histidine kinase/HSP90-like ATPase	Domain
A, B	IPR002645	STAS domain	Domain
A, B	IPR036890	Histidine kinase/HSP90-like ATPase superfamily	Homologous Superfamily
A, B	IPR035965	PAS domain superfamily	Homologous Superfamily
A, B	IPR036513	STAS domain superfamily	Homologous Superfamily
A, B	IPR000700	PAS-associated, C-terminal	Domain
A, B	IPR001932	PPM-type phosphatase-like domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.