Annotations: 3KCI

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RCC1	e3kciA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: RCC1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.130.10.30	Mainly Beta	7 Propeller	Methylamine Dehydrogenase	Chain H	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00415	Regulator of chromosome condensation (RCC1) repeat (RCC1)	Regulator of chromosome condensation (RCC1) repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Probable E3 ubiquitin-protein ligase HERC2	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity SUMO binding protein binding binding ubiquitin-like protein binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation organonitrogen compound metabolic process primary metabolic process organic substance metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal organonitrogen compound catabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process organic substance catabolic process protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA repair	membrane cellular anatomical entity intracellular organelle microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle centriole microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell periphery membrane cellular anatomical entity intracellular organelle microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle centriole microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR037976	HERC2, APC10 domain	Domain
A	IPR000408	Regulator of chromosome condensation, RCC1	Repeat
A	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
A	IPR006624	Beta-propeller repeat TECPR	Repeat
A	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
A	IPR010606	Mib-herc2	Domain
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR035983	HECT, E3 ligase catalytic domain	Homologous Superfamily
A	IPR000433	Zinc finger, ZZ-type	Domain
A	IPR036400	Cytochrome b5-like heme/steroid binding domain superfamily	Homologous Superfamily
A	IPR000569	HECT domain	Domain
A	IPR037252	Mib/herc2 domain superfamily	Homologous Superfamily
A	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II	Homologous Superfamily
A	IPR041987	HERC2, zinc finger, ZZ-type	Domain
A	IPR004939	APC10/DOC domain	Domain
A	IPR021097	CPH domain	Domain
A	IPR001199	Cytochrome b5-like heme/steroid binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95714	developmental delay with autism spectrum disorder and gait instability ulcerative colitis intellectual disability occupational asthma melanoma Prader-Willi syndrome skin basal cell carcinoma vitiligo age-related macular degeneration breast adenocarcinoma cutaneous melanoma Neoplasm of uncertain or unknown behavior of breast ovarian cancer squamous cell carcinoma amyotrophic lateral sclerosis developmental delay with autism spectrum disorder and gait instability ulcerative colitis intellectual disability occupational asthma melanoma Prader-Willi syndrome skin basal cell carcinoma vitiligo age-related macular degeneration breast adenocarcinoma cutaneous melanoma Neoplasm of uncertain or unknown behavior of breast ovarian cancer squamous cell carcinoma amyotrophic lateral sclerosis breast carcinoma Pick disease schizophrenia autosomal recessive non-syndromic intellectual disability corneal disease glioblastoma osteosarcoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.