3K39

Crystal Structure of B/Perth Neuraminidase D197E mutant in complex with Peramivir

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C	d3k39c_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
I	d3k39i_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
N	d3k39n_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
A	d3k39a_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
B	d3k39b_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
D	d3k39d_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
E	d3k39e_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
F	d3k39f_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
G	d3k39g_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
H	d3k39h_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
J	d3k39j_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
K	d3k39k_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
L	d3k39l_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
M	d3k39m_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
O	d3k39o_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)
P	d3k39p_	All beta proteins	6-bladed beta-propeller	Sialidases	Sialidases (neuraminidases)	Influenza neuraminidase	Viruses (Influenza B virus (B/Perth/211/2001) ) [TaxId: 343983 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Sialidases	8071712	3001607	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF00064	e3k39C1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
I	PF00064	e3k39I1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
N	PF00064	e3k39N1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
A	PF00064	e3k39A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
B	PF00064	e3k39B1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
D	PF00064	e3k39D1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
E	PF00064	e3k39E1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
F	PF00064	e3k39F1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
G	PF00064	e3k39G1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
H	PF00064	e3k39H1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
J	PF00064	e3k39J1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
K	PF00064	e3k39K1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
L	PF00064	e3k39L1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
M	PF00064	e3k39M1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
O	PF00064	e3k39O1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)
P	PF00064	e3k39P1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF00064	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
I	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
N	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
A	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
B	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
D	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
E	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
F	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
G	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
H	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
J	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
K	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
L	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
M	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
O	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)
P	2.120.10.10	Mainly Beta	6 Propeller	Neuraminidase		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	PF00064	Neuraminidase (Neur)	Neuraminidase	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	Neuraminidase	hydrolase activity, acting on glycosyl bonds exo-alpha-(2->6)-sialidase activity alpha-sialidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity exo-alpha-sialidase activity catalytic activity exo-alpha-(2->8)-sialidase activity exo-alpha-(2->3)-sialidase activity cation binding ion binding binding metal ion binding small molecule binding	carbohydrate metabolic process organic substance metabolic process primary metabolic process metabolic process	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane virion component virion membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR001860	Glycoside hydrolase, family 34	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P	IPR036278	Sialidase superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.