3K1L

Crystal Structure of FANCL

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	RING/U-box like	8053880	3000160	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	UBC-like	8053877	3000570	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	UBC-like	8053879	3000570	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	UBC-like	8053876	3000570	SCOP2B (2022-06-29)
B [auth A]	SCOP2 Family	FANCL C-terminal RING domain	8046994	4005404	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Family	DRWD domain-like	8045574	4004541	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Family	ELF domain-like	8053878	4007622	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	RING/U-box like	8053880	3000160	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	UBC-like	8053876	3000570	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	UBC-like	8053877	3000570	SCOP2 (2022-06-29)
B [auth A]	SCOP2 Superfamily	UBC-like	8053879	3000570	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF09765	e3k1lB1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF09765	ECOD (1.6)
A [auth B]	PF18890	e3k1lB2	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF18890	ECOD (1.6)
A [auth B]	PF18891	e3k1lB3	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF18891	ECOD (1.6)
A [auth B]	PF11793	e3k1lB4	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF11793	ECOD (1.6)
B [auth A]	PF09765	e3k1lA1	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF09765	ECOD (1.6)
B [auth A]	PF18890	e3k1lA2	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF18890	ECOD (1.6)
B [auth A]	PF18891	e3k1lA3	A: a+b two layers	X: UBC-like	H: UBC-like (From Topology)	T: UBC-like	F: PF18891	ECOD (1.6)
B [auth A]	PF11793	e3k1lA4	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: PF11793	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.30.457.40	Alpha Beta	2-Layer Sandwich	Copper Amine Oxidase	Chain A, domain 1	CATH (4.3.0)
A [auth B]	3.30.457.30	Alpha Beta	2-Layer Sandwich	Copper Amine Oxidase	Chain A, domain 1	CATH (4.3.0)
B [auth A]	3.30.457.40	Alpha Beta	2-Layer Sandwich	Copper Amine Oxidase	Chain A, domain 1	CATH (4.3.0)
B [auth A]	3.30.457.30	Alpha Beta	2-Layer Sandwich	Copper Amine Oxidase	Chain A, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF18890	FANCL UBC-like domain 2 (FANCL_d2)	FANCL UBC-like domain 2	This entry represents the second of three UBC-like domain found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nucl ...	This entry represents the second of three UBC-like domain found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.	Domain
A [auth B], B [auth A]	PF18891	FANCL UBC-like domain 3 (FANCL_d3)	FANCL UBC-like domain 3	This entry represents the third of three UBC-like domain found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nucle ...	This entry represents the third of three UBC-like domain found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.	Domain
A [auth B], B [auth A]	PF09765	FANCL UBC-like domain 1 (FANCL_d1)	FANCL UBC-like domain 1	This entry represents the first of three UBC-like domain found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nucle ...	This entry represents the first of three UBC-like domain found in the FANCL protein, which is the catalytic E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia). Eight subunits of the Fanconi anaemia gene products form a multisubunit nuclear complex which is required for mono-ubiquitination of a downstream FA protein, FANCD2.	Domain
A [auth B], B [auth A]	PF11793	FANCL C-terminal domain (FANCL_C)	FANCL C-terminal domain	This domain is found at the C-terminus of the Fancl protein in humans which is the E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia) that mediates monoubiquitination of FANCD2. This entry represents the RING domain which recruits the UB ...	This domain is found at the C-terminus of the Fancl protein in humans which is the E3 ubiquitin ligase subunit of the FA complex (Fanconi anaemia) that mediates monoubiquitination of FANCD2. This entry represents the RING domain which recruits the UBE2T ubiquitin conjugating E2 enzyme as other RING E3s [2,3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Fancl	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity cation binding ion binding binding metal ion binding small molecule binding	cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process macromolecule metabolic process DNA repair interstrand cross-link repair organonitrogen compound metabolic process protein monoubiquitination protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle Fanconi anaemia nuclear complex intracellular organelle protein-containing complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR026850	FANCL C-terminal domain	Domain
A [auth B], B [auth A]	IPR019162	Fanconi anemia complex, subunit FancL, WD-repeat containing domain	Domain
A [auth B], B [auth A]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A [auth B], B [auth A]	IPR026848	E3 ubiquitin-protein ligase FANCL	Family
A [auth B], B [auth A]	IPR044037	FANCL, UBC-like domain 3	Domain
A [auth B], B [auth A]	IPR043003	FANCL, UBC-like domain 3 superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR043898	FANCL, UBC-like domain 2	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.