Annotations: 3JV3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00018	e3jv3A2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF00018	ECOD (1.6)
A	PF00621	e3jv3A1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: PF00621	ECOD (1.6)
B	PF00621	e3jv3B1	A: alpha bundles	X: DH domain-like	H: DBL homology domain (DH-domain) (From Topology)	T: DBL homology domain (DH-domain)	F: PF00621	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.30.30.40	Mainly Beta	Roll	SH3 type barrels.	SH3 Domains	CATH (4.3.0)
A	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)
B	1.20.900.10	Mainly Alpha	Up-down Bundle	Dbl Homology Domain	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00018	SH3 domain (SH3_1)	SH3 domain	SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organisation. First described in the Src cytoplasmic tyrosine kinase Swiss:P12931. The structure is a partly opened beta barrel.	Domain
A, B	PF00621	RhoGEF domain (RhoGEF)	RhoGEF domain	Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Intersectin-1	enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity protein binding binding proline-rich region binding molecular adaptor activity cation binding ion binding calcium ion binding metal ion binding enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity kinase regulator activity protein binding binding proline-rich region binding molecular adaptor activity cation binding ion binding calcium ion binding metal ion binding small molecule binding GTPase regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process multicellular organismal process regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development positive regulation of biological process cell development regulation of dendritic spine development protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process multicellular organismal process regulation of developmental process cellular developmental process cell projection organization positive regulation of dendritic spine development positive regulation of biological process cell development regulation of dendritic spine development neuron projection development cellular component organization positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation dendrite development cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process dendritic spine development regulation of biological process plasma membrane bounded cell projection organization biological regulation nervous system development generation of neurons neuron development import into cell regulation of localization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization transport caveolin-mediated endocytosis vesicle-mediated transport positive regulation of endocytosis positive regulation of cellular process regulation of endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization positive regulation of transport positive regulation of caveolin-mediated endocytosis regulation of caveolin-mediated endocytosis endocytosis establishment of localization in cell intracellular transport endosomal transport synaptic vesicle endocytosis synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle endosomal processing synaptic vesicle recycling via endosome synaptic vesicle recycling clathrin-dependent synaptic vesicle endocytosis clathrin-dependent endocytosis receptor-mediated endocytosis cellular response to stimulus small GTPase-mediated signal transduction response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction postsynapse organization regulation of postsynapse organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality establishment of protein localization nitrogen compound transport organic substance transport protein transport positive regulation of cell communication regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signal transduction regulation of signal transduction positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of response to stimulus regulation of cell communication phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of signaling neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of neuron apoptotic process secretion by cell exocytosis secretion export from cell regulation of modification of postsynaptic actin cytoskeleton regulation of modification of synaptic structure modification of postsynaptic actin cytoskeleton regulation of modification of postsynaptic structure modification of synaptic structure modification of postsynaptic structure regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion regulation of secretion positive regulation of growth hormone secretion regulation of hormone secretion regulation of peptide secretion positive regulation of secretion by cell hormone secretion peptide secretion regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion growth hormone secretion regulation of growth hormone secretion regulation of peptide transport cell-cell signaling peptide transport peptide hormone secretion hormone transport	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle cytoplasm cytosol cell periphery presynapse synapse cell junction plasma membrane presynaptic membrane plasma membrane region synaptic membrane intracellular vesicle cytoplasmic vesicle vesicle endocytic vesicle glutamatergic synapse axon neuron projection axon terminus distal axon calyx of Held neuron projection terminus endosome recycling endosome neuron spine dendritic spine somatodendritic compartment postsynapse dendrite dendritic tree cell body neuronal cell body actin cytoskeleton cytoskeleton intracellular non-membrane-bounded organelle postsynaptic cytoskeleton postsynaptic actin cytoskeleton non-membrane-bounded organelle presynaptic endocytic zone apical dendrite

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000219	Dbl homology (DH) domain	Domain
A, B	IPR000261	EH domain	Domain
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR002048	EF-hand domain	Domain
A, B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B	IPR001452	SH3 domain	Domain
A, B	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A, B	IPR001849	Pleckstrin homology domain	Domain
A, B	IPR000008	C2 domain	Domain
A, B	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR035892	C2 domain superfamily	Homologous Superfamily
A, B	IPR032140	Intersectin-1, AP2 binding region	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.