3JBH

TWO HEAVY MEROMYOSIN INTERACTING-HEADS MOTIFS FLEXIBLE DOCKED INTO TARANTULA THICK FILAMENT 3D-MAP ALLOWS IN DEPTH STUDY OF INTRA- AND INTERMOLECULAR INTERACTIONS

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2 Family	Calmodulin-like	8062894	4000924	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	EF-hand	8062895	3001983	SCOP2 (2022-06-29)
D	SCOP2B Superfamily	EF-hand	8062895	3001983	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	EF-hand	8062895	3001983	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	EF-hand	8062895	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02736	e3jbhA1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
A	F_UNCLASSIFIED	e3jbhA2	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00063	e3jbhA3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)
B	PF02736	e3jbhB1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
B	F_UNCLASSIFIED	e3jbhB3	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF00063	e3jbhB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)
G	PF02736	e3jbhG3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
G	F_UNCLASSIFIED	e3jbhG1	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: F_UNCLASSIFIED	ECOD (1.6)
G	PF00063	e3jbhG2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)
H	PF02736	e3jbhH3	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF02736	ECOD (1.6)
H	F_UNCLASSIFIED	e3jbhH4	A: alpha bundles	X: Myosin VI lever arm (From Topology)	H: Myosin VI lever arm (From Topology)	T: Myosin VI lever arm	F: F_UNCLASSIFIED	ECOD (1.6)
H	PF00063	e3jbhH1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00063	ECOD (1.6)
C	F_UNCLASSIFIED	e3jbhC1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e3jbhD2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
I	F_UNCLASSIFIED	e3jbhI2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
J	F_UNCLASSIFIED	e3jbhJ2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e3jbhE1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
E	PF13405	e3jbhE2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13405	ECOD (1.6)
F	F_UNCLASSIFIED	e3jbhF2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
F	PF13405	e3jbhF1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13405	ECOD (1.6)
K	F_UNCLASSIFIED	e3jbhK1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
K	PF13405	e3jbhK2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13405	ECOD (1.6)
L	F_UNCLASSIFIED	e3jbhL2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: F_UNCLASSIFIED	ECOD (1.6)
L	PF13405	e3jbhL1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13405	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, G, H	PF02736	Myosin N-terminal SH3-like domain (Myosin_N)	Myosin N-terminal SH3-like domain	This domain has an SH3-like fold. It is found at the N-terminus of many but not all myosins. The function of this domain is unknown.	Domain
A, B, G, H	PF00063	Myosin head (motor domain) (Myosin_head)	Myosin head (motor domain)	-	Domain
A, B, G, H	PF01576	Myosin tail (Myosin_tail_1)	Myosin tail	-	Coiled-coil
E, F, K, L	PF13833	EF-hand domain pair (EF-hand_8)	EF-hand domain pair	-	Domain
E, F, K, L	PF13405	EF-hand domain (EF-hand_6)	EF-hand domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, G, H	MYOSIN 2 HEAVY CHAIN STRIATED MUSCLE	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding cytoskeletal motor activity	-	intracellular anatomical structure cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle protein-containing complex intracellular anatomical structure cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle protein-containing complex cytoskeleton actin cytoskeleton myosin complex
C, D, I, J	MYOSIN 2 ESSENTIAL LIGHT CHAIN STRIATED MUSCLE	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	intracellular organelle protein-containing complex intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle cellular anatomical entity actin cytoskeleton non-membrane-bounded organelle myosin complex
E, F, K, L	MYOSIN 2 REGULATORY LIGHT CHAIN STRIATED MUSCLE	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, G, H	IPR036961	Kinesin motor domain superfamily	Homologous Superfamily
A, B, G, H	IPR014751	DNA repair protein XRCC4-like, C-terminal	Homologous Superfamily
A, B, G, H	IPR001609	Myosin head, motor domain	Domain
A, B, G, H	IPR002928	Myosin tail	Domain
A, B, G, H	IPR004009	Myosin, N-terminal, SH3-like	Domain
A, B, G, H	IPR008989	Myosin S1 fragment, N-terminal	Homologous Superfamily
A, B, G, H	IPR000048	IQ motif, EF-hand binding site	Binding Site
A, B, G, H	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, D, I, J	IPR002048	EF-hand domain	Domain
C, D, I, J	IPR011992	EF-hand domain pair	Homologous Superfamily
E, F, K, L	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
E, F, K, L	IPR002048	EF-hand domain	Domain
E, F, K, L	IPR011992	EF-hand domain pair	Homologous Superfamily