3J92

Structure and assembly pathway of the ribosome quality control complex

External Resource: Annotation


Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
KA [auth l]Ribosomal_L39e3j92l1 A: extended segmentsX: Ribosomal protein L39e (From Topology)H: Ribosomal protein L39e (From Topology)T: Ribosomal protein L39eF: Ribosomal_L39ECOD (1.6)
ARibosomal_L2_1e3j92A1 A: beta barrelsX: OB-foldH: Nucleic acid-binding proteins (From Topology)T: Nucleic acid-binding proteinsF: Ribosomal_L2_1ECOD (1.6)
ARibosomal_L2_C_2e3j92A2 A: beta barrelsX: SH3H: SH3T: SH3F: Ribosomal_L2_C_2ECOD (1.6)
JRibosomal_L5_Ce3j92J1 A: a+b two layersX: Ribosomal protein L5 (From Topology)H: Ribosomal protein L5 (From Topology)T: Ribosomal protein L5F: Ribosomal_L5_CECOD (1.6)
K [auth L]Ribosomal_L13ee3j92L1 A: extended segmentsX: RPL13 (From Topology)H: RPL13 (From Topology)T: RPL13F: Ribosomal_L13eECOD (1.6)
L [auth M]Ribosomal_L14ee3j92M1 A: beta barrelsX: SH3H: SH3T: SH3F: Ribosomal_L14eECOD (1.6)
M [auth N]Ribosomal_L15ee3j92N1 A: a+b two layersX: Alpha-beta plaitsH: Ribosomal proteins S24e, L23 and L15e (From Topology)T: Ribosomal proteins S24e, L23 and L15eF: Ribosomal_L15eECOD (1.6)
N [auth O]Ribosomal_L13e3j92O1 A: a/b three-layered sandwichesX: Ribosomal protein L13/L15p/L18e/L32eH: Ribosomal protein L13 and L16-A (From Topology)T: Ribosomal protein L13 and L16-AF: Ribosomal_L13ECOD (1.6)
O [auth P]Ribosomal_L22e3j92P1 A: a+b two layersX: Enolase-N/ribosomal proteinH: Ribosomal protein L22 (From Topology)T: Ribosomal protein L22F: Ribosomal_L22ECOD (1.6)
P [auth Q]Ribosomal_L18e3j92Q1 A: a/b three-layered sandwichesX: Ribosomal protein L13/L15p/L18e/L32eH: Ribosomal proteins L15p and L18e (From Topology)T: Ribosomal proteins L15p and L18eF: Ribosomal_L18ECOD (1.6)
Q [auth R]Ribosomal_L19e_Ne3j92R1 A: alpha arraysX: Ribosomal protein L19 (L19e) N-terminal domain (From Topology)H: Ribosomal protein L19 (L19e) N-terminal domain (From Topology)T: Ribosomal protein L19 (L19e) N-terminal domainF: Ribosomal_L19e_NECOD (1.6)
Q [auth R]Ribosomal_L19e_Ce3j92R2 A: alpha bundlesX: Ribosomal protein L19 (L19e) C-terminal domain (From Topology)H: Ribosomal protein L19 (L19e) C-terminal domain (From Topology)T: Ribosomal protein L19 (L19e) C-terminal domainF: Ribosomal_L19e_CECOD (1.6)
R [auth S]Ribosomal_L18Ae3j92S2 A: a+b two layersX: GP2-likeH: RplX-like (From Topology)T: RplX-likeF: Ribosomal_L18AECOD (1.6)
S [auth T]Ribosomal_L21ee3j92T1 A: beta barrelsX: SH3H: SH3T: SH3F: Ribosomal_L21eECOD (1.6)
BRibosomal_L3e3j92B1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: Ribosomal_L3ECOD (1.6)
T [auth U]Ribosomal_L22ee3j92U1 A: a+b two layersX: Ribosomal protein L22e (From Topology)H: Ribosomal protein L22e (From Topology)T: Ribosomal protein L22eF: Ribosomal_L22eECOD (1.6)
U [auth V]Ribosomal_L14e3j92V1 A: beta barrelsX: Ribosomal protein L14-likeH: Ribosomal protein L14-related (From Topology)T: Ribosomal protein L14-relatedF: Ribosomal_L14ECOD (1.6)
V [auth W]Ribosomal_L24ee3j92W1 A: few secondary structure elementsX: Glucocorticoid receptor-likeH: LIM domain-likeT: LIM domain-likeF: Ribosomal_L24eECOD (1.6)
W [auth X]Ribosomal_L23_3e3j92X1 A: a+b two layersX: Alpha-beta plaitsH: Ribosomal proteins S24e, L23 and L15e (From Topology)T: Ribosomal proteins S24e, L23 and L15eF: Ribosomal_L23_3ECOD (1.6)
X [auth Y]Ribosomal_L26e3j92Y1 A: beta barrelsX: SH3H: SH3T: SH3F: Ribosomal_L26ECOD (1.6)
Y [auth Z]Ribosomal_L27ee3j92Z1 A: beta barrelsX: SH3H: SH3T: SH3F: Ribosomal_L27eECOD (1.6)
Z [auth a]Ribosomal_L18e3j92a1 A: a/b three-layered sandwichesX: Ribosomal protein L13/L15p/L18e/L32eH: Ribosomal proteins L15p and L18e (From Topology)T: Ribosomal proteins L15p and L18eF: Ribosomal_L18ECOD (1.6)
AA [auth b]Ribosomal_L29ee3j92b1 A: extended segmentsX: RPL29 (From Topology)H: RPL29 (From Topology)T: RPL29F: Ribosomal_L29eECOD (1.6)
BA [auth c]Ribosomal_L7Aee3j92c1 A: a+b three layersX: Bacillus chorismate mutase-likeH: L30e-like (From Topology)T: L30e-likeF: Ribosomal_L7AeECOD (1.6)
CA [auth d]Ribosomal_L31ee3j92d1 A: a+b two layersX: Ribosomal protein L31e-likeH: Ribosomal protein L31e/gp120 outer domain (From Topology)T: Ribosomal protein L31e/gp120 outer domainF: Ribosomal_L31eECOD (1.6)
CRibosomal_L4e3j92C2 A: a/b three-layered sandwichesX: Ribosomal protein L4 (From Topology)H: Ribosomal protein L4 (From Topology)T: Ribosomal protein L4F: Ribosomal_L4ECOD (1.6)
CRibos_L4_asso_Ce3j92C1 A: extended segmentsX: C-terminal helical region in 60S ribosomal protein L4 (L4p) (From Topology)H: C-terminal helical region in 60S ribosomal protein L4 (L4p) (From Topology)T: C-terminal helical region in 60S ribosomal protein L4 (L4p)F: Ribos_L4_asso_CECOD (1.6)
DA [auth e]Ribosomal_L32ee3j92e1 A: a/b three-layered sandwichesX: Ribosomal protein L13/L15p/L18e/L32eH: Ribosomal protein L32e (From Topology)T: Ribosomal protein L32eF: Ribosomal_L32eECOD (1.6)
EA [auth f]Ribosomal_L35Aee3j92f1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: Alanine racemase-CF: Ribosomal_L35AeECOD (1.6)
FA [auth g]Ribosomal_L34ee3j92g1 A: few secondary structure elementsX: Glucocorticoid receptor-likeH: RPL34 (From Topology)T: RPL34F: Ribosomal_L34eECOD (1.6)
GA [auth h]Ribosomal_L29_2e3j92h1 A: alpha bundlesX: Long alpha-hairpinH: Ribosomal protein L29 (L29p) (From Topology)T: Ribosomal protein L29 (L29p)F: Ribosomal_L29_2ECOD (1.6)
HA [auth i]Ribosomal_L36ee3j92i1 A: alpha arraysX: 60S ribosomal protein rpL36 (L36e) (From Topology)H: 60S ribosomal protein rpL36 (L36e) (From Topology)T: 60S ribosomal protein rpL36 (L36e)F: Ribosomal_L36eECOD (1.6)
IA [auth j]Ribosomal_L37ee3j92j1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: Ribosomal_L37eECOD (1.6)
JA [auth k]Ribosomal_L38ee3j92k1 A: a+b two layersX: SRP9/14-likeH: Signal recognition particle alu RNA binding heterodimer SRP9/14-related (From Topology)T: Signal recognition particle alu RNA binding heterodimer SRP9/14-relatedF: Ribosomal_L38eECOD (1.6)
LA [auth m]Ribosomal_L40ee3j92m1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: Ribosomal_L40eECOD (1.6)
MA [auth o]Ribosomal_L44e3j92o1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: Ribosomal_L44ECOD (1.6)
DRibosomal_L5ee3j92D1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: Ribosomal_L5eECOD (1.6)
NA [auth p]Ribosomal_L37aee3j92p1 A: few secondary structure elementsX: Rubredoxin-likeH: Rubredoxin-relatedT: Rubredoxin-relatedF: Ribosomal_L37aeECOD (1.6)
OA [auth r]Ribosomal_L28ee3j92r1 A: a+b two layersX: RPL28 (From Topology)H: RPL28 (From Topology)T: RPL28F: Ribosomal_L28eECOD (1.6)
PA [auth s]Ribosomal_L10e3j92s2 A: a+b two layersX: Alpha-beta plaitsH: Ribosomal protein L10-like (From Topology)T: Ribosomal protein L10-likeF: Ribosomal_L10ECOD (1.6)
PA [auth s]Ribosomal_P0_L10ee3j92s1 A: a+b two layersX: Insertion domain in 60S ribosomal protein rpP0 (L10P) (From Topology)H: Insertion domain in 60S ribosomal protein rpP0 (L10P) (From Topology)T: Insertion domain in 60S ribosomal protein rpP0 (L10P)F: Ribosomal_P0_L10eECOD (1.6)
QA [auth t]Ribosomal_L11e3j92t1 A: alpha arraysX: HTHH: HTHT: Ribosomal protein L11, C-terminal domainF: Ribosomal_L11ECOD (1.6)
QA [auth t]Ribosomal_L11_Ne3j92t2 A: a+b two layersX: Ribosomal protein L11/L12e N-terminal domain-likeH: Ribosomal protein L11/L12e N-terminal domain (From Topology)T: Ribosomal protein L11/L12e N-terminal domainF: Ribosomal_L11_NECOD (1.6)
RA [auth u]FbpA_1ste3j92u1 A: beta barrelsX: MutM N-terminal domain-likeH: Fibrinogen binding protein N-terminal domain (From Topology)T: Fibrinogen binding protein N-terminal domainF: FbpA_1stECOD (1.6)
ERibosomal_L6ee3j92E1 A: beta barrelsX: SH3H: SH3T: SH3F: Ribosomal_L6eECOD (1.6)
FRibosomal_L30_1e3j92F1 A: a+b two layersX: Ribosomal protein L30p/L7e (From Topology)H: Ribosomal protein L30p/L7e (From Topology)T: Ribosomal protein L30p/L7eF: Ribosomal_L30_1ECOD (1.6)
GRibosomal_L7Ae_1e3j92G1 A: a+b three layersX: Bacillus chorismate mutase-likeH: L30e-like (From Topology)T: L30e-likeF: Ribosomal_L7Ae_1ECOD (1.6)
HRibosomal_L6_2e3j92H2 A: a+b two layersX: Ribosomal protein L6 (From Topology)H: Ribosomal protein L6 (From Topology)T: Ribosomal protein L6F: Ribosomal_L6_2ECOD (1.6)
HRibosomal_L6e3j92H1 A: a+b two layersX: Ribosomal protein L6 (From Topology)H: Ribosomal protein L6 (From Topology)T: Ribosomal protein L6F: Ribosomal_L6ECOD (1.6)
IRibosomal_L16e3j92I1 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: Ribosomal protein L10eF: Ribosomal_L16ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
RA [auth u],
SA [auth v]		PF05833NFACT N-terminal and middle domains (NFACT_N)NFACT N-terminal and middle domains- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
KA [auth l]eL39---
uL2---
uL5---
K [auth L]eL13---
L [auth M]eL14---
M [auth N]eL15---
N [auth O]uL13---
O [auth P]uL22---
P [auth Q]eL18---
Q [auth R]eL19---
R [auth S]eL20---
S [auth T]eL21---
uL3---
T [auth U]eL22---
U [auth V]uL14---
V [auth W]eL24---
W [auth X]uL23---
X [auth Y]uL24---
Y [auth Z]eL27---
Z [auth a]uL15---
AA [auth b]eL29---
BA [auth c]eL30---
CA [auth d]eL31---
uL4---
DA [auth e]eL32---
EA [auth f]eL33---
FA [auth g]eL34---
GA [auth h]uL29---
HA [auth i]eL36---
IA [auth j]eL37---
JA [auth k]eL38---
LA [auth m]eL40---
MA [auth o]eL42---
uL18---
NA [auth p]eL43---
OA [auth r]eL28---
PA [auth s]uL10---
QA [auth t]uL11---
RA [auth u],
SA [auth v]		NEMF
TA [auth w],
WA [auth z],
XA [auth 0]		Listerin
UA [auth x],
VA [auth y]		Listerin---
YA [auth 1]nascent chain---
ZA [auth 2]tRNA---
AB [auth 5]28S rRNA---
eL6---
BB [auth 7]5S rRNA---
CB [auth 8]5.8S rRNA---
eL30---
eL8---
uL6---
uL16---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
RA [auth u],
SA [auth v]		IPR008532NFACT, RNA-binding domainDomain
RA [auth u],
SA [auth v]		IPR021846NFACT protein, C-terminalDomain
TA [auth w],
WA [auth z],
XA [auth 0]		IPR016024Armadillo-type foldHomologous Superfamily
TA [auth w],
WA [auth z],
XA [auth 0]		IPR039795E3 ubiquitin-protein ligase listerinFamily
TA [auth w],
WA [auth z],
XA [auth 0]		IPR013083Zinc finger, RING/FYVE/PHD-typeHomologous Superfamily
TA [auth w],
WA [auth z],
XA [auth 0]		IPR011016Zinc finger, RING-CH-typeDomain
TA [auth w],
WA [auth z],
XA [auth 0]		IPR011989Armadillo-like helicalHomologous Superfamily
TA [auth w],
WA [auth z],
XA [auth 0]		IPR039804Listerin, zinc finger, RING-typeDomain
TA [auth w],
WA [auth z],
XA [auth 0]		IPR001841Zinc finger, RING-typeDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
RA [auth u],
SA [auth v]		Pharos:  O60524
TA [auth w],
WA [auth z],
XA [auth 0]		Pharos:  O94822