Annotations: 3IYV

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
E [auth C]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
G [auth D]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
I [auth E]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
K [auth F]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
K [auth F]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
K [auth F]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
M [auth G]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
M [auth G]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
M [auth G]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
O [auth H]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
O [auth H]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)
O [auth H]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
Q [auth I]	SCOP2B Superfamily	Clathrin heavy-chain terminal domain-like	8042014	3001710	SCOP2B (2022-06-29)
Q [auth I]	SCOP2B Superfamily	ARM repeat-like	8042013	3000116	SCOP2B (2022-06-29)
Q [auth I]	SCOP2B Superfamily	ARM repeat-like	8038574	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Clathrin_propel	e3iyvA2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
A	Clathrin_H_link	e3iyvA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
C [auth B]	Clathrin_propel	e3iyvB2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
C [auth B]	Clathrin_H_link	e3iyvB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
E [auth C]	Clathrin_propel	e3iyvC2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
E [auth C]	Clathrin_H_link	e3iyvC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
G [auth D]	Clathrin_propel	e3iyvD2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
G [auth D]	Clathrin_H_link	e3iyvD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
I [auth E]	Clathrin_propel	e3iyvE2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
I [auth E]	Clathrin_H_link	e3iyvE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
K [auth F]	Clathrin_propel	e3iyvF2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
K [auth F]	Clathrin_H_link	e3iyvF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
M [auth G]	Clathrin_propel	e3iyvG2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
M [auth G]	Clathrin_H_link	e3iyvG1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
O [auth H]	Clathrin_propel	e3iyvH2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
O [auth H]	Clathrin_H_link	e3iyvH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
Q [auth I]	Clathrin_propel	e3iyvI2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: Clathrin_propel	ECOD (1.6)
Q [auth I]	Clathrin_H_link	e3iyvI1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Clathrin_H_link	ECOD (1.6)
B [auth J]	Clathrin_lg_ch	e3iyvJ1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
D [auth K]	Clathrin_lg_ch	e3iyvK1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
F [auth L]	Clathrin_lg_ch	e3iyvL1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
H [auth M]	Clathrin_lg_ch	e3iyvM1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
J [auth N]	Clathrin_lg_ch	e3iyvN1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
L [auth O]	Clathrin_lg_ch	e3iyvO1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
N [auth P]	Clathrin_lg_ch	e3iyvP1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
P [auth Q]	Clathrin_lg_ch	e3iyvQ1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)
R	Clathrin_lg_ch	e3iyvR1	A: extended segments	X: Clathrin light chain B (From Topology)	H: Clathrin light chain B (From Topology)	T: Clathrin light chain B	F: Clathrin_lg_ch	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	PF09268	Clathrin, heavy-chain linker (Clathrin-link)	Clathrin, heavy-chain linker	-	Repeat
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	PF00637	Region in Clathrin and VPS (Clathrin)	Region in Clathrin and VPS	-	Repeat
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	PF13838	Clathrin-H-link (Clathrin_H_link)	Clathrin-H-link	-	Repeat
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	PF01394	Clathrin propeller repeat (Clathrin_propel)	Clathrin propeller repeat	-	Repeat
B [auth J], D [auth K], F [auth L], H [auth M], J [auth N], B [auth J], D [auth K], F [auth L], H [auth M], J [auth N], L [auth O], N [auth P], P [auth Q], R	PF01086	Clathrin light chain (Clathrin_lg_ch)	Clathrin light chain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	Clathrin heavy chain	clathrin binding protein binding binding clathrin light chain binding protein domain specific binding arrestin family protein binding structural molecule activity disordered domain specific binding identical protein binding	cellular process cell cycle mitotic cell cycle cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly transport protein-containing complex organization cellular process cell cycle mitotic cell cycle cell division cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism cellular component disassembly clathrin coat disassembly transport protein-containing complex organization protein-containing complex disassembly establishment of localization vesicle-mediated transport vesicle uncoating cellular component organization localization cellular component organization or biogenesis protein depolymerization protein localization cellular localization establishment of protein localization nitrogen compound transport organic substance transport intracellular transport protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport clathrin coat assembly cellular component biogenesis cellular component assembly protein-containing complex assembly regulation of cellular process negative regulation of biological process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process organic substance biosynthetic process glycosaminoglycan biosynthetic process negative regulation of carbohydrate metabolic process regulation of biological process negative regulation of metabolic process carbohydrate biosynthetic process regulation of cellular metabolic process primary metabolic process negative regulation of cellular biosynthetic process hyaluronan biosynthetic process biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process mucopolysaccharide metabolic process cellular biosynthetic process glycosaminoglycan metabolic process regulation of hyaluronan biosynthetic process regulation of polysaccharide metabolic process negative regulation of hyaluronan biosynthetic process organic substance metabolic process hyaluronan metabolic process polysaccharide metabolic process negative regulation of cellular process regulation of carbohydrate metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process carbohydrate derivative biosynthetic process carbohydrate metabolic process organonitrogen compound metabolic process polysaccharide biosynthetic process biological regulation regulation of macromolecule metabolic process macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of biosynthetic process regulation of polysaccharide biosynthetic process aminoglycan metabolic process aminoglycan biosynthetic process regulation of carbohydrate biosynthetic process import into cell receptor-mediated endocytosis endocytosis	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex coated membrane membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit clathrin coat of coated pit pigment granule intracellular vesicle melanosome cytoplasmic vesicle vesicle clathrin complex cytoskeleton spindle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle clathrin-coated endocytic vesicle clathrin-coated vesicle coated vesicle endocytic vesicle vesicle coat transport vesicle membrane clathrin coat of trans-Golgi network vesicle bounding membrane of organelle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle vesicle membrane clathrin vesicle coat Golgi-associated vesicle clathrin-coated vesicle membrane transport vesicle Golgi apparatus coated vesicle membrane cytoplasmic vesicle membrane Golgi-associated vesicle membrane organelle membrane
B [auth J], D [auth K], F [auth L], H [auth M], J [auth N], B [auth J], D [auth K], F [auth L], H [auth M], J [auth N], L [auth O], N [auth P], P [auth Q], R	Clathrin light chain A	structural molecule activity clathrin heavy chain binding clathrin binding protein binding binding	cellular process cell cycle protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization cellular process cell cycle protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport cell division import into cell clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis vesicle-mediated transport	protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm protein-containing complex intracellular anatomical structure plasma membrane protein complex membrane plasma membrane membrane protein complex cellular anatomical entity coated membrane endomembrane system clathrin coat membrane coat cell periphery clathrin-coated pit cytoplasm clathrin coat of coated pit intracellular organelle cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle membrane-bounded organelle synapse intracellular vesicle transport vesicle membrane presynapse bounding membrane of organelle cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane intracellular membrane-bounded organelle cytoplasmic vesicle membrane secretory vesicle organelle membrane exocytic vesicle vesicle coat clathrin coat of trans-Golgi network vesicle trans-Golgi network transport vesicle membrane trans-Golgi network transport vesicle clathrin-coated vesicle clathrin vesicle coat coated vesicle Golgi-associated vesicle clathrin-coated vesicle membrane Golgi apparatus coated vesicle membrane Golgi-associated vesicle membrane cell cortex cytoplasmic region postsynaptic endocytic zone cytoplasmic component postsynaptic endocytic zone postsynapse cell cortex region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR016341	Clathrin, heavy chain	Family
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR015348	Clathrin, heavy chain, linker, core motif	Domain
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR016024	Armadillo-type fold	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR016025	Clathrin heavy chain, N-terminal	Homologous Superfamily
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR000547	Clathrin, heavy chain/VPS, 7-fold repeat	Repeat
A, C [auth B], E [auth C], G [auth D], I [auth E], A, C [auth B], E [auth C], G [auth D], I [auth E], K [auth F], M [auth G], O [auth H], Q [auth I]	IPR022365	Clathrin, heavy chain, propeller repeat	Repeat
B [auth J], D [auth K], F [auth L], H [auth M], J [auth N], B [auth J], D [auth K], F [auth L], H [auth M], J [auth N], L [auth O], N [auth P], P [auth Q], R	IPR000996	Clathrin light chain	Family