3IVP

The structure of a possible transposon-related DNA-binding protein from Clostridium difficile 630.

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	HTH_3_1	e3ivpA1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HTH_3_1	ECOD (1.6)
A	PET_testin_like	e3ivpA2	A: alpha duplicates or obligate multimers	X: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	H: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	T: Putative transposon-related DNA-binding protein dimerization domain	F: PET_testin_like	ECOD (1.6)
B	HTH_3_1	e3ivpB1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HTH_3_1	ECOD (1.6)
B	PET_testin_like	e3ivpB2	A: alpha duplicates or obligate multimers	X: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	H: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	T: Putative transposon-related DNA-binding protein dimerization domain	F: PET_testin_like	ECOD (1.6)
C	HTH_3_1	e3ivpC1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HTH_3_1	ECOD (1.6)
C	PET_testin_like	e3ivpC2	A: alpha duplicates or obligate multimers	X: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	H: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	T: Putative transposon-related DNA-binding protein dimerization domain	F: PET_testin_like	ECOD (1.6)
D	HTH_3_1	e3ivpD1	A: alpha arrays	X: HTH	H: HTH	T: tetra-helical, lambda repressor-like	F: HTH_3_1	ECOD (1.6)
D	PET_testin_like	e3ivpD2	A: alpha duplicates or obligate multimers	X: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	H: Putative transposon-related DNA-binding protein dimerization domain (From Topology)	T: Putative transposon-related DNA-binding protein dimerization domain	F: PET_testin_like	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
A	6.10.140.640	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
B	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
B	6.10.140.640	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
C	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
C	6.10.140.640	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)
D	1.10.260.40	Mainly Alpha	Orthogonal Bundle	434 Repressor (Amino-terminal Domain)	lambda repressor-like DNA-binding domains	CATH (4.3.0)
D	6.10.140.640	Special	Helix non-globular	Helix Hairpins		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01381	Helix-turn-helix (HTH_3)	Helix-turn-helix	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be ...	This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].	Domain
A, B, C, D	PF18430	Putative DNA-binding domain (DBD_HTH)	Putative DNA-binding domain	This is a putative DNA-binding protein dimerization domain found bacterial proteins such as CD3330, (a transposon-related DNA-binding protein from Clostridium difficile). Crystal structure analysis suggests that CD3330 N-terminus is involved in dimer ...	This is a putative DNA-binding protein dimerization domain found bacterial proteins such as CD3330, (a transposon-related DNA-binding protein from Clostridium difficile). Crystal structure analysis suggests that CD3330 N-terminus is involved in dimer formation and also in crystal packing but the C-terminus is open to solvent [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Putative transposon-related DNA-binding protein	DNA binding binding organic cyclic compound binding nucleic acid binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR041511	Putative DNA-binding domain	Domain
A, B, C, D	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
A, B, C, D	IPR010982	Lambda repressor-like, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.