3IUO

The Crystal Structure of the C-terminal domain of the ATP-dependent DNA helicase RecQ from Porphyromonas gingivalis to 1.6A

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3iuoA2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF21220	e3iuoA1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF21220	ECOD (1.6)
B	F_UNCLASSIFIED	e3iuoB2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF21220	e3iuoB1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF21220	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.10.1390	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	ATP-dependent DNA helicase RecQ	CATH (4.3.0)
B	1.10.10.1390	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	ATP-dependent DNA helicase RecQ	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF21220	RecQ-1-like, helix-turn-helix domain (RecQ-1-like_HTH)	RecQ-1-like, helix-turn-helix domain	This domain is found in a group of bacterial DNA helicases, including RecQ-1 from Porphyromonas gingivalis, which shows an all-helical structure [1]. This entry represents the helix-turn-helix (HTH) domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	ATP-dependent DNA helicase RecQ	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding nucleic acid binding hydrolase activity catalytic activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity 3'-5' DNA helicase activity ATP-dependent activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular response to stimulus response to stimulus cellular response to stress DNA damage response response to stress cellular process DNA repair SOS response DNA recombination	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006293	DNA helicase, ATP-dependent, RecQ type, bacterial	Family
A, B	IPR010997	HRDC-like superfamily	Homologous Superfamily
A, B	IPR002121	HRDC domain	Domain
A, B	IPR001650	Helicase, C-terminal domain-like	Domain
A, B	IPR018982	RQC domain	Domain
A, B	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A, B	IPR032284	ATP-dependent DNA helicase RecQ, zinc-binding domain	Domain
A, B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR044876	HRDC domain superfamily	Homologous Superfamily
A, B	IPR048671	RecQ-1-like, helix-turn-helix domain	Domain
A, B	IPR011545	DEAD/DEAH box helicase domain	Domain
A, B	IPR004589	DNA helicase, ATP-dependent, RecQ type	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.