3IUG

Crystal structure of the RhoGAP domain of RICS

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3iuga1	All alpha proteins	GTPase activation domain, GAP	GTPase activation domain, GAP	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3iuga2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3iugb_	All alpha proteins	GTPase activation domain, GAP	GTPase activation domain, GAP	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	BCR-homology GTPase activation domain (RhoGAP-domain)	8079470	4001255	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	GTPase activation domain GAP	8079471	3001163	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	GTPase activation domain GAP	8079471	3001163	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00620	e3iugA1	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: PF00620	ECOD (1.6)
B	PF00620	e3iugB1	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: PF00620	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.555.10	Mainly Alpha	Orthogonal Bundle	Phosphatidylinositol 3-kinase	Chain A	CATH (4.3.0)
B	1.10.555.10	Mainly Alpha	Orthogonal Bundle	Phosphatidylinositol 3-kinase	Chain A	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Rho/Cdc42/Rac GTPase-activating protein RICS	binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication cellular process signal transduction	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle neuron spine synapse neuron projection dendritic spine plasma membrane bounded cell projection somatodendritic compartment cell projection postsynapse cell junction dendrite dendritic tree cytosol postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle vesicle nucleus membrane-enclosed lumen nucleolus intracellular organelle lumen organelle lumen fibrillar center nuclear lumen nucleoplasm organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000198	Rho GTPase-activating protein domain	Domain
A, B	IPR036871	PX domain superfamily	Homologous Superfamily
A, B	IPR001452	SH3 domain	Domain
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A, B	IPR042139	Rho GTPase-activating protein 32, PX domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: A7KAX9	pilocytic astrocytoma schizophrenia astrocytic tumor brain aneurysm interstitial cystitis large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer spina bifida atrial fibrillation ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer pilocytic astrocytoma schizophrenia astrocytic tumor brain aneurysm interstitial cystitis large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm pituitary cancer spina bifida atrial fibrillation ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor tuberculosis atypical teratoid rhabdoid tumor glioblastoma Jacobsen syndrome malignant ependymoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.