Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThymidylat_synte3iroA1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
ADHFR_1e3iroA2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
BThymidylat_synte3iroB2 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
BDHFR_1e3iroB3 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
CThymidylat_synte3iroC2 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
CDHFR_1e3iroC3 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)
DThymidylat_synte3iroD1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
DDHFR_1e3iroD2 A: a/b three-layered sandwichesX: Dihydrofolate reductases (From Topology)H: Dihydrofolate reductases (From Topology)T: Dihydrofolate reductasesF: DHFR_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain
A, B, C, D
PF00186Dihydrofolate reductase (DHFR_1)Dihydrofolate reductase- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D
Bifunctional dihydrofolate reductase-thymidylate synthase -