Annotations: 3IJ2

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cystine-knot cytokines	8038790	3000846	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Cystine-knot cytokines	8038790	3000846	SCOP2B (2022-06-29)
B [auth X]	SCOP2B Superfamily	TNF receptor-like	8039414	3000971	SCOP2B (2022-06-29)
B [auth X]	SCOP2B Superfamily	TNF receptor-like	8039415	3000971	SCOP2B (2022-06-29)
B [auth X]	SCOP2B Superfamily	TNF receptor-like	8039412	3000971	SCOP2B (2022-06-29)
B [auth X]	SCOP2B Superfamily	TNF receptor-like	8039413	3000971	SCOP2B (2022-06-29)
D [auth Y]	SCOP2B Superfamily	TNF receptor-like	8039413	3000971	SCOP2B (2022-06-29)
D [auth Y]	SCOP2B Superfamily	TNF receptor-like	8039412	3000971	SCOP2B (2022-06-29)
D [auth Y]	SCOP2B Superfamily	TNF receptor-like	8039414	3000971	SCOP2B (2022-06-29)
D [auth Y]	SCOP2B Superfamily	TNF receptor-like	8039415	3000971	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00243	e3ij2A1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00243	ECOD (1.6)
C [auth B]	PF00243	e3ij2B1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF00243	ECOD (1.6)
B [auth X]	F_UNCLASSIFIED	e3ij2X2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth X]	PF00020	e3ij2X3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: PF00020	ECOD (1.6)
D [auth Y]	F_UNCLASSIFIED	e3ij2Y2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth Y]	PF00020	e3ij2Y3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: TNF receptor-like	F: PF00020	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
C [auth B]	2.10.90.10	Mainly Beta	Ribbon	Cystine Knot Cytokines, subunit B	Cystine-knot cytokines	CATH (4.3.0)
B [auth X]	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (4.3.0)
D [auth Y]	2.10.50.10	Mainly Beta	Ribbon	Tumor Necrosis Factor Receptor, subunit A	domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B]	PF00243	Nerve growth factor family (NGF)	Nerve growth factor family	-	Domain
B [auth X], D [auth Y]	PF00020	TNFR/NGFR cysteine-rich region (TNFR_c6)	TNFR/NGFR cysteine-rich region	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B]	Beta-nerve growth factor	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity nerve growth factor receptor binding cytokine receptor binding neurotrophin receptor binding tumor necrosis factor receptor superfamily binding death receptor binding protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity nerve growth factor receptor binding cytokine receptor binding neurotrophin receptor binding tumor necrosis factor receptor superfamily binding death receptor binding enzyme regulator activity molecular function inhibitor activity peptidase regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity metalloendopeptidase inhibitor activity endopeptidase inhibitor activity enzyme activator activity cysteine-type endopeptidase activator activity involved in apoptotic process cysteine-type endopeptidase regulator activity involved in apoptotic process peptidase activator activity peptidase activator activity involved in apoptotic process death receptor agonist activity protein tyrosine kinase activator activity transmembrane receptor protein tyrosine kinase activator activity protein kinase regulator activity kinase activator activity protein kinase activator activity kinase regulator activity lipid binding	regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process regulation of molecular function positive regulation of molecular function regulation of DNA binding regulation of binding biological regulation positive regulation of binding positive regulation of DNA binding regulation of cellular process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process axon extension multicellular organismal process positive regulation of nervous system development regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development positive regulation of developmental process multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development positive regulation of cell projection organization regulation of biological quality positive regulation of developmental growth system development developmental process regulation of cell projection organization positive regulation of cell development nervous system development developmental growth involved in morphogenesis generation of neurons positive regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development neurogenesis regulation of extent of cell growth positive regulation of cell differentiation regulation of axonogenesis positive regulation of neurogenesis regulation of multicellular organismal process positive regulation of axon extension cellular component organization or biogenesis positive regulation of axonogenesis regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth growth positive regulation of cell growth axon development regulation of cell growth cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis positive regulation of growth neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation behavior system process learning or memory nervous system process cognition memory regulation of stem cell proliferation cell population proliferation positive regulation of cell population proliferation positive regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation cellular response to stimulus extrinsic apoptotic signaling pathway via death domain receptors response to stimulus cell surface receptor signaling pathway signaling cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway signal transduction apoptotic process programmed cell death regulation of localization cellular localization transport modulation of chemical synaptic transmission localization synaptic signaling regulation of secretion by cell secretion by cell signal release establishment of localization in cell trans-synaptic signaling regulation of signaling neurotransmitter secretion regulation of transport secretion regulation of neurotransmitter transport export from cell cell-cell signaling neurotransmitter transport establishment of localization regulation of secretion chemical synaptic transmission signal release from synapse regulation of trans-synaptic signaling regulation of neurotransmitter secretion anterograde trans-synaptic signaling regulation of cell communication positive regulation of neuron projection development signal transduction in absence of ligand extrinsic apoptotic signaling pathway in absence of ligand regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of type B pancreatic cell apoptotic process regulation of apoptotic process negative regulation of biological process regulation of programmed cell death epithelial cell apoptotic process type B pancreatic cell apoptotic process negative regulation of type B pancreatic cell apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process negative regulation of cellular process positive regulation of collateral sprouting regulation of collateral sprouting collateral sprouting nerve development positive regulation of cell maturation regulation of neuron maturation cell maturation regulation of cell maturation positive regulation of neuron maturation developmental maturation anatomical structure maturation neuron maturation regulation of neuron differentiation regulation of calcium ion transport intracellular calcium ion homeostasis calcium ion transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis inorganic ion homeostasis homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion calcium ion transmembrane import into cytosol sequestering of calcium ion cellular homeostasis regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus cellular response to endogenous stimulus nerve growth factor signaling pathway neurotrophin signaling pathway response to nerve growth factor response to growth factor rhythmic process circadian rhythm adult locomotory behavior adult behavior locomotory behavior positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling cell surface receptor protein tyrosine kinase signaling pathway positive regulation of neurotrophin TRK receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of cellular response to growth factor stimulus neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway regulation of protein ubiquitination positive regulation of post-translational protein modification protein ubiquitination regulation of protein modification by small protein conjugation or removal positive regulation of protein modification by small protein conjugation or removal positive regulation of protein ubiquitination regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process positive regulation of neuron differentiation peripheral nervous system development sensory perception sensory perception of pain small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction positive regulation of Ras protein signal transduction Ras protein signal transduction positive regulation of small GTPase mediated signal transduction protein autophosphorylation regulation of protein autophosphorylation positive regulation of protein autophosphorylation	somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen somatodendritic compartment cell projection dendrite dendritic tree neuron projection cellular anatomical entity plasma membrane bounded cell projection membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm axon extracellular region extracellular space transport vesicle synapse intracellular vesicle presynapse cytoplasmic vesicle synaptic vesicle cell junction secretory vesicle vesicle exocytic vesicle endosome endosome lumen
B [auth X], D [auth Y]	Nerve growth factor receptor (TNFR superfamily, member 16)	small GTPase binding protein binding binding enzyme binding GTPase binding amide binding amyloid-beta binding peptide binding molecular transducer activity coreceptor activity signaling receptor activity neurotrophin binding nerve growth factor binding growth factor binding small GTPase binding protein binding binding enzyme binding GTPase binding amide binding amyloid-beta binding peptide binding molecular transducer activity coreceptor activity signaling receptor activity neurotrophin binding nerve growth factor binding growth factor binding neurotrophin TRK receptor binding neurotrophin TRKA receptor binding signaling receptor binding cytokine receptor binding neurotrophin receptor binding protein-containing complex binding calmodulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding identical protein binding transmembrane signaling receptor activity death receptor activity preprotein binding	cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cellular response to stimulus positive regulation of cell communication multicellular organismal process regulation of postsynaptic membrane potential system process regulation of cellular process positive regulation of signal transduction response to stimulus signaling modulation of chemical synaptic transmission regulation of system process positive regulation of excitatory postsynaptic potential positive regulation of biological process regulation of signal transduction chemical synaptic transmission, postsynaptic cell communication positive regulation of response to stimulus synaptic signaling modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality positive regulation of cellular process trans-synaptic signaling regulation of biological process regulation of signaling cell surface receptor signaling pathway nervous system process biological regulation cell-cell signaling chemical synaptic transmission regulation of nervous system process regulation of trans-synaptic signaling regulation of response to stimulus anterograde trans-synaptic signaling regulation of cell communication cellular process excitatory postsynaptic potential regulation of membrane potential positive regulation of signaling cellular homeostasis chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis intracellular chemical homeostasis intracellular glucose homeostasis developmental process multicellular organism development central nervous system development anatomical structure development nervous system development system development presynaptic modulation of chemical synaptic transmission regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of mitochondrial depolarization negative regulation of membrane depolarization negative regulation of biological process mitochondrial depolarization regulation of membrane depolarization regulation of mitochondrial membrane potential membrane depolarization negative regulation of mitochondrial depolarization regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process epithelium development epidermis development molting cycle process hair cycle epidermis morphogenesis animal organ development morphogenesis of an epithelium tissue development tissue morphogenesis anatomical structure morphogenesis skin development skin epidermis development hair follicle development molting cycle hair cycle process hair follicle morphogenesis regulation of neuron projection development regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development cellular component organization neurogenesis neuron differentiation cell differentiation negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization negative regulation of neuron projection development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization skeletal muscle cell differentiation skeletal muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription positive regulation of biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription response to oxidative stress cellular response to chemical stimulus cellular response to stress response to stress response to chemical cellular response to oxidative stress cellular response to chemical stress rhythmic process circadian regulation of gene expression circadian rhythm positive regulation of cellular component organization positive regulation of neuron projection development positive regulation of cell projection organization fibroblast proliferation cell population proliferation regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis endothelial cell proliferation angiogenesis negative regulation of endothelial cell proliferation tube morphogenesis epithelial cell proliferation blood vessel development negative regulation of cell population proliferation negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis blood vessel morphogenesis tube development blood vessel endothelial cell proliferation involved in sprouting angiogenesis sprouting angiogenesis vasculature development circulatory system development regulation of endothelial cell proliferation regulation of cell population proliferation anatomical structure formation involved in morphogenesis regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion nerve development small GTPase-mediated signal transduction Rho protein signal transduction intracellular signal transduction intracellular signaling cassette artery development aorta development dorsal aorta development regulation of developmental process negative regulation of dendritic spine development regulation of dendritic spine development dendrite development dendritic spine development negative regulation of developmental process positive regulation of cell population proliferation positive regulation of neural precursor cell proliferation neural precursor cell proliferation regulation of neural precursor cell proliferation response to fibroblast growth factor cellular response to growth factor stimulus negative regulation of signaling negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction fibroblast growth factor receptor signaling pathway response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization regulation of animal organ morphogenesis regulation of odontogenesis of dentin-containing tooth regulation of odontogenesis odontogenesis of dentin-containing tooth odontogenesis positive regulation of odontogenesis positive regulation of developmental process positive regulation of odontogenesis of dentin-containing tooth positive regulation of animal organ morphogenesis positive regulation of multicellular organismal process animal organ morphogenesis regulation of anatomical structure morphogenesis synaptic transmission, glutamatergic regulation of synaptic transmission, glutamatergic positive regulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic negative regulation of programmed cell death negative regulation of apoptotic process regulation of fibroblast proliferation positive regulation of fibroblast proliferation regulation of small GTPase mediated signal transduction regulation of intracellular signal transduction positive regulation of intracellular signal transduction regulation of Rho protein signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process detection of external stimulus detection of stimulus detection of temperature stimulus response to external stimulus response to abiotic stimulus response to temperature stimulus detection of abiotic stimulus regulation of myelination regulation of nervous system development positive regulation of myelination axon ensheathment ensheathment of neurons positive regulation of nervous system process regulation of multicellular organismal development myelination establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization protein transport establishment of localization in cell intracellular protein transport positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade regulation of cell differentiation positive regulation of neuron differentiation positive regulation of cell differentiation regulation of neuron differentiation axonogenesis plasma membrane bounded cell projection morphogenesis cell morphogenesis cell projection morphogenesis neuron projection morphogenesis axon guidance axon development cell morphogenesis involved in neuron differentiation neuron projection guidance regulation of vasculature development negative regulation of blood vessel morphogenesis negative regulation of angiogenesis negative regulation of vasculature development regulation of angiogenesis negative regulation of multicellular organismal process reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process regulation of hair cycle regulation of hair follicle development negative regulation of hair follicle development positive regulation of synaptic transmission, cholinergic synaptic transmission, cholinergic regulation of synaptic transmission, cholinergic cellular response to nitrogen compound response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to amyloid-beta cellular response to oxygen-containing compound cellular response to organonitrogen compound cellular response to organic substance response to amyloid-beta biological process involved in interspecies interaction between organisms response to lipid response to other organism response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin	somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cell-cell junction anchoring junction cell junction somatodendritic compartment cell body perikaryon neuronal cell body cellular anatomical entity cell periphery cell surface membrane plasma membrane external side of plasma membrane side of membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle endomembrane system presynapse synapse presynaptic membrane plasma membrane region synaptic membrane cytoplasm neuromuscular junction neuron spine neuron projection dendritic spine plasma membrane bounded cell projection cell projection postsynapse dendrite dendritic tree neuronal cell body membrane cell body membrane growth cone axon distal axon site of polarized growth cell leading edge leading edge membrane neuron projection membrane dendrite membrane cell projection membrane postsynaptic density neuron to neuron synapse postsynaptic specialization asymmetric synapse intracellular vesicle clathrin-coated endocytic vesicle cytoplasmic vesicle clathrin-coated vesicle coated vesicle vesicle endocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B]	IPR029034	Cystine-knot cytokine	Homologous Superfamily
A, C [auth B]	IPR002072	Nerve growth factor-related	Domain
A, C [auth B]	IPR020408	Nerve growth factor-like	Family
A, C [auth B]	IPR019846	Nerve growth factor conserved site	Conserved Site
A, C [auth B]	IPR020437	Nerve growth factor, beta subunit, mammalian	Family
A, C [auth B]	IPR020425	Nerve growth factor, beta subunit	Family
B [auth X], D [auth Y]	IPR000488	Death domain	Domain
B [auth X], D [auth Y]	IPR022325	Tumour necrosis factor receptor 16	Family
B [auth X], D [auth Y]	IPR041448	Tumor necrosis factor receptor member 16, transmembrane domain	Domain
B [auth X], D [auth Y]	IPR034046	Tumor necrosis factor receptor 16, N-terminal	Domain
B [auth X], D [auth Y]	IPR011029	Death-like domain superfamily	Homologous Superfamily
B [auth X], D [auth Y]	IPR001368	TNFR/NGFR cysteine-rich region	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.