Annotations: 3IG3

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF08337	e3ig3A3	A: alpha bundles	X: GTPase activation domain, GAP (From Topology)	H: GTPase activation domain, GAP (From Topology)	T: GTPase activation domain, GAP	F: PF08337	ECOD (1.6)
A	PF20170	e3ig3A4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF20170	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.506.10	Mainly Alpha	Orthogonal Bundle	GTPase Activation - p120GAP	domain 1	CATH (4.3.0)
A	3.10.20.90	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Phosphatidylinositol 3-kinase Catalytic Subunit	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF20170	Plexin cytoplasmic RhoGTPase-binding domain (Plexin_RBD)	Plexin cytoplasmic RhoGTPase-binding domain	This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins [1].	Domain
A	PF08337	Plexin cytoplasmic RasGAP domain (Plexin_cytopl)	Plexin cytoplasmic RasGAP domain	This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytop ...	This family features the C-terminal regions of various plexins (e.g. Swiss:P51805). Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels [1,2]. The cytoplasmic region, which has been called a SEX domain in some members of this family [3], is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins [4]. This domain acts as a RasGAP domain [5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Plxna3 protein	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity semaphorin receptor activity	developmental process multicellular organismal process cranial nerve morphogenesis parasympathetic nervous system development nervous system development anatomical structure morphogenesis multicellular organism development cranial nerve structural organization nerve development cranial nerve development central nervous system development preganglionic parasympathetic fiber development anatomical structure development anatomical structure arrangement developmental process multicellular organismal process cranial nerve morphogenesis parasympathetic nervous system development nervous system development anatomical structure morphogenesis multicellular organism development cranial nerve structural organization nerve development cranial nerve development central nervous system development preganglionic parasympathetic fiber development anatomical structure development anatomical structure arrangement facial nerve morphogenesis autonomic nervous system development facial nerve structural organization system development facial nerve development head development forebrain development animal organ development brain development pallium development telencephalon development hippocampus development limbic system development pyramidal neuron development cellular developmental process central nervous system neuron development cell development neurogenesis central nervous system neuron differentiation neuron differentiation cell differentiation forebrain generation of neurons generation of neurons forebrain neuron development neuron development cellular process forebrain neuron differentiation pyramidal neuron differentiation axon extension axonogenesis cell projection organization developmental growth plasma membrane bounded cell projection morphogenesis neuron projection development cell morphogenesis cell growth cellular component organization cell projection morphogenesis neuron projection morphogenesis axon extension involved in axon guidance cellular component organization or biogenesis neuron projection extension involved in neuron projection guidance neuron projection extension plasma membrane bounded cell projection organization developmental cell growth growth axon guidance axon development cell morphogenesis involved in neuron differentiation developmental growth involved in morphogenesis neuron projection guidance negative regulation of locomotion response to stimulus negative regulation of chemotaxis regulation of cell development regulation of biological quality chemotaxis regulation of cell projection organization response to external stimulus negative regulation of axonogenesis negative regulation of developmental growth regulation of response to stimulus negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization regulation of developmental process regulation of response to external stimulus negative regulation of neurogenesis regulation of axon extension involved in axon guidance regulation of extent of cell growth negative regulation of nervous system development negative regulation of cell differentiation regulation of anatomical structure morphogenesis locomotion regulation of developmental growth negative regulation of developmental process negative regulation of axon extension regulation of chemotaxis regulation of cell growth negative regulation of cell development regulation of growth regulation of cellular process regulation of cellular component size negative regulation of biological process regulation of cell differentiation regulation of neurogenesis negative regulation of growth taxis regulation of biological process negative regulation of cellular component organization negative regulation of axon extension involved in axon guidance negative regulation of cell growth response to chemical regulation of locomotion negative regulation of response to external stimulus regulation of axon extension regulation of nervous system development regulation of axonogenesis negative regulation of cellular process regulation of multicellular organismal process negative regulation of cell projection organization regulation of cell size regulation of multicellular organismal development negative regulation of response to stimulus biological regulation negative regulation of neuron projection development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size positive regulation of nervous system development positive regulation of developmental process positive regulation of cell projection organization positive regulation of cell development positive regulation of multicellular organismal process positive regulation of cellular component organization positive regulation of biological process positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of axonogenesis positive regulation of cellular process positive regulation of organelle organization regulation of cytoskeleton organization positive regulation of cytoskeleton organization regulation of organelle organization organelle organization cytoskeleton organization regulation of cell motility regulation of cell migration cell migration cell motility motor neuron axon guidance branchiomotor neuron axon guidance regulation of cell shape regulation of cell morphogenesis gonadotrophin-releasing hormone neuronal migration to the hypothalamus hypothalamus development hypothalamus cell differentiation hypothalamus gonadotrophin-releasing hormone neuron development neuron migration hypothalamus gonadotrophin-releasing hormone neuron differentiation diencephalon development hypothalamic tangential migration using cell-axon interactions hypothalamus cell migration trigeminal nerve development trigeminal nerve structural organization trigeminal nerve morphogenesis cellular response to stimulus cell surface receptor signaling pathway semaphorin-plexin signaling pathway signaling cell communication signal transduction negative chemotaxis olfactory nerve development cranial nerve formation olfactory nerve morphogenesis olfactory nerve formation anatomical structure formation involved in morphogenesis cell adhesion regulation of cell adhesion negative regulation of cell adhesion semaphorin-plexin signaling pathway involved in neuron projection guidance semaphorin-plexin signaling pathway involved in axon guidance	cell periphery plasma membrane membrane cellular anatomical entity protein-containing complex semaphorin receptor complex receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002909	IPT domain	Domain
A	IPR041362	Plexin, TIG domain 2	Domain
A	IPR016201	PSI domain	Domain
A	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR002165	Plexin repeat	Repeat
A	IPR041019	Plexin, TIG domain 1	Domain
A	IPR031148	Plexin family	Family
A	IPR046800	Plexin, cytoplasmic RhoGTPase-binding domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR013548	Plexin, cytoplasmic RasGAP domain	Domain
A	IPR036352	Sema domain superfamily	Homologous Superfamily
A	IPR001627	Sema domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.