3IFQ

Interction of plakoglobin and beta-catenin with desmosomal cadherins

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3ifqa_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3ifqb_	All alpha proteins	alpha-alpha superhelix	ARM repeat	Armadillo repeat	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Armadillo repeat	8080314	4001272	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ARM repeat-like	8080315	3000116	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8080315	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00514	e3ifqA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00514	ECOD (1.6)
B	PF00514	e3ifqB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF00514	ECOD (1.6)
C	PF01049	e3ifqC1	A: extended segments	X: E-cadherin (From Topology)	H: E-cadherin (From Topology)	T: E-cadherin	F: PF01049	ECOD (1.6)
D	PF01049	e3ifqD1	A: extended segments	X: E-cadherin (From Topology)	H: E-cadherin (From Topology)	T: E-cadherin	F: PF01049	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (4.3.0)
C	4.10.900.10	Few Secondary Structures	Irregular	TCF3-CBD (Catenin binding domain)	TCF3-CBD (Catenin binding domain)	CATH (4.3.0)
D	4.10.900.10	Few Secondary Structures	Irregular	TCF3-CBD (Catenin binding domain)	TCF3-CBD (Catenin binding domain)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00514	Armadillo/beta-catenin-like repeat (Arm)	Armadillo/beta-catenin-like repeat	-	Repeat
C, D	PF01049	Cadherin, Y-type LIR-motif (CADH_Y-type_LIR)	Cadherin, Y-type LIR-motif	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	plakoglobin	protein binding binding alpha-catenin binding cytoskeletal protein-membrane anchor activity protein-membrane adaptor activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity protein phosphatase binding phosphatase binding enzyme binding cell adhesion molecule binding cadherin binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication protein binding binding alpha-catenin binding cytoskeletal protein-membrane anchor activity protein-membrane adaptor activity protein-macromolecule adaptor activity cytoskeletal anchor activity molecular adaptor activity protein phosphatase binding phosphatase binding enzyme binding cell adhesion molecule binding cadherin binding cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication cell adhesion mediator activity cell-cell adhesion mediator activity protein binding involved in heterotypic cell-cell adhesion transcription coactivator activity transcription regulator activity transcription coregulator activity identical protein binding protein homodimerization activity protein dimerization activity transcription factor binding DNA-binding transcription factor binding structural molecule activity	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway regulation of cell-substrate adhesion positive regulation of cell adhesion cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling canonical Wnt signaling pathway biological regulation cell communication cellular process signal transduction Wnt signaling pathway regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion positive regulation of biological process cell-substrate adhesion positive regulation of cell-matrix adhesion cell adhesion cell-matrix adhesion positive regulation of cell-substrate adhesion regulation of cell-matrix adhesion positive regulation of cellular process positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process heart process multicellular organismal process system process regulation of heart contraction regulation of system process homotypic cell-cell adhesion heterotypic cell-cell adhesion circulatory system process cell-cell adhesion regulation of multicellular organismal process cell communication involved in cardiac conduction blood circulation bundle of His cell to Purkinje myocyte communication cardiac muscle cell-cardiac muscle cell adhesion regulation of blood circulation cardiac conduction bundle of His cell-Purkinje myocyte adhesion involved in cell communication heart contraction regulation of actin filament-based process cardiac muscle cell action potential involved in contraction regulation of ventricular cardiac muscle cell action potential cardiac muscle contraction striated muscle contraction regulation of cardiac muscle cell action potential actin filament-based process regulation of biological quality cardiac muscle cell contraction regulation of action potential ventricular cardiac muscle cell action potential regulation of cardiac muscle contraction action potential actin filament-based movement muscle contraction muscle system process regulation of muscle system process regulation of striated muscle contraction regulation of actin filament-based movement regulation of muscle contraction regulation of cardiac muscle cell contraction actin-mediated cell contraction cardiac muscle cell action potential regulation of membrane potential protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane cell migration cell motility regulation of localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization import into nucleus establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport regulation of protein localization transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport protein localization to organelle negative regulation of locomotion regulation of cell motility regulation of blood vessel endothelial cell migration endothelial cell migration negative regulation of biological process negative regulation of endothelial cell migration negative regulation of blood vessel endothelial cell migration tissue migration negative regulation of epithelial cell migration ameboidal-type cell migration regulation of cell migration negative regulation of cellular process blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration regulation of epithelial cell migration locomotion negative regulation of cell migration epithelium migration regulation of locomotion negative regulation of cell motility negative regulation of multicellular organismal process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of heart rate by cardiac conduction regulation of heart rate developmental process skin development animal organ development anatomical structure development detection of external stimulus detection of stimulus detection of mechanical stimulus response to mechanical stimulus response to external stimulus response to abiotic stimulus detection of abiotic stimulus epithelial cell-cell adhesion endothelial cell-cell adhesion desmosome organization desmosome assembly cellular component organization cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cellular component organization or biogenesis cell-cell junction assembly cell-cell junction organization regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process multicellular organism development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development system development regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process cellular response to nitrogen compound response to organic substance response to alcohol response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to alcohol cellular response to organonitrogen compound response to indole-3-methanol cellular response to indole-3-methanol response to chemical cellular response to organic substance response to organic cyclic compound cell population proliferation regulation of cell population proliferation positive regulation of cell communication positive regulation of signal transduction regulation of canonical Wnt signaling pathway regulation of signal transduction positive regulation of response to stimulus positive regulation of Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of signaling	cell periphery plasma membrane membrane cellular anatomical entity cornified envelope intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm cell periphery plasma membrane membrane cellular anatomical entity cornified envelope intracellular anatomical structure Z disc sarcomere intracellular organelle I band organelle intracellular non-membrane-bounded organelle contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cell-cell junction anchoring junction cell junction extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane protein complex extrinsic component of membrane adherens junction cytoskeleton desmosome vesicle lumen intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen intracellular membrane-bounded organelle secretory granule lumen endomembrane system intracellular organelle lumen cytoplasmic vesicle organelle lumen specific granule lumen secretory granule secretory vesicle specific granule nucleus nuclear protein-containing complex gamma-catenin-TCF7L2 complex catenin-TCF7L2 complex intercalated disc cell-cell contact zone focal adhesion cell-substrate junction polymeric cytoskeletal fiber intermediate filament cytoskeleton intermediate filament apical junction complex zonula adherens ficolin-1-rich granule ficolin-1-rich granule lumen protein-DNA complex cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane
C, D	E-cadherin	protein binding binding alpha-catenin binding cytoskeletal protein binding ankyrin binding protein phosphatase binding phosphatase binding enzyme binding cell adhesion molecule binding cadherin binding molecular adaptor activity protein tyrosine kinase binding kinase binding protein kinase binding protein binding binding alpha-catenin binding cytoskeletal protein binding ankyrin binding protein phosphatase binding phosphatase binding enzyme binding cell adhesion molecule binding cadherin binding molecular adaptor activity protein tyrosine kinase binding kinase binding protein kinase binding identical protein binding gamma-catenin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding protein domain specific binding GTPase activating protein binding beta-catenin binding	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization cellular response to stimulus developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development adherens junction organization cellular component organization cell junction organization cellular process cellular component organization or biogenesis cell-cell junction organization cellular response to stimulus cellular response to inorganic substance cellular response to metal ion cellular response to lithium ion response to stimulus response to inorganic substance cellular response to chemical stimulus response to lithium ion response to metal ion response to chemical regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling canonical Wnt signaling pathway biological regulation cell communication signal transduction Wnt signaling pathway axon extension multicellular organismal process regulation of growth axonogenesis regulation of cellular component size developmental growth cell projection organization negative regulation of biological process regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development multicellular organism development cell projection morphogenesis neuron differentiation negative regulation of growth neuron projection morphogenesis cell differentiation regulation of biological quality system development negative regulation of cellular component organization regulation of cell projection organization negative regulation of cell growth nervous system development developmental growth involved in morphogenesis generation of neurons negative regulation of axonogenesis negative regulation of developmental growth negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension regulation of nervous system development neurogenesis negative regulation of neurogenesis regulation of extent of cell growth regulation of axonogenesis negative regulation of cellular process negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth negative regulation of developmental process growth negative regulation of axon extension axon development regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of neuron projection development anatomical structure morphogenesis negative regulation of cell development neuron development regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size establishment of skin barrier epithelium development skin development skin epidermis development epidermis development tissue development regulation of biosynthetic process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of signaling regulation of canonical Wnt signaling pathway regulation of signal transduction negative regulation of cell communication negative regulation of Wnt signaling pathway regulation of signaling regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane organelle organization actin cytoskeleton organization actin filament-based process cytoskeleton organization cellular component biogenesis cellular component assembly cell junction assembly cell-cell junction assembly regulation of localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization import into nucleus establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport regulation of protein localization transport positive regulation of nucleocytoplasmic transport positive regulation of biological process regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport positive regulation of cellular process regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport protein localization to organelle embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development regulation of cell adhesion negative regulation of cell adhesion cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion regulation of cell-cell adhesion bicellular tight junction assembly tight junction organization apical junction assembly tight junction assembly reproductive system development oviduct development oviduct epithelium development tube development reproductive process uterus development developmental process involved in reproduction reproductive structure development uterine epithelium development cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to organic substance response to amino acid negative regulation of locomotion regulation of cell motility regulation of locomotion regulation of cell migration negative regulation of cell motility cell migration cell motility negative regulation of cell migration locomotion organonitrogen compound metabolic process primary metabolic process protein metabolic process digestive system development intestinal epithelial cell differentiation intestinal epithelial cell development digestive tract development epithelial cell differentiation epithelial cell development columnar/cuboidal epithelial cell development columnar/cuboidal epithelial cell differentiation system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation synapse organization synapse assembly calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules salivary gland cavitation gland development salivary gland development tube formation tube morphogenesis gland morphogenesis salivary gland morphogenesis anatomical structure formation involved in morphogenesis tube lumen cavitation animal organ morphogenesis exocrine system development negative regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of protein localization regulation of protein localization to cell periphery negative regulation of protein localization to membrane negative regulation of protein localization to cell periphery regulation of protein localization to plasma membrane protein localization to cell surface regulation of protein localization to cell surface epithelial cell morphogenesis positive regulation of cell adhesion positive regulation of cell-cell adhesion neuron migration regulation of neuron migration trophectodermal cell differentiation blastocyst formation blastocyst development cell-cell adhesion mediated by cadherin multi-multicellular organism process female pregnancy embryo implantation multi-organism reproductive process catabolic process modulation of chemical synaptic transmission macromolecule catabolic process regulation of protein catabolic process at postsynapse, modulating synaptic transmission regulation of primary metabolic process synaptic signaling postsynaptic modulation of chemical synaptic transmission organonitrogen compound catabolic process trans-synaptic signaling regulation of protein metabolic process cell-cell signaling protein catabolic process regulation of catabolic process chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling organic substance catabolic process regulation of protein catabolic process placenta development maternal process involved in female pregnancy multicellular organismal reproductive process maternal placenta development decidualization regulation of protein maturation negative regulation of proteolysis negative regulation of protein maturation negative regulation of cellular metabolic process protein maturation regulation of proteolysis proteolysis negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of protein processing protein processing negative regulation of protein processing cellular response to nitrogen compound response to alcohol response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to alcohol cellular response to organonitrogen compound response to indole-3-methanol cellular response to indole-3-methanol cellular response to organic substance response to organic cyclic compound positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process branching involved in salivary gland morphogenesis regulation of branching involved in salivary gland morphogenesis regulation of morphogenesis of an epithelium regulation of morphogenesis of a branching structure regulation of animal organ morphogenesis morphogenesis of an epithelium tissue morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane apical part of cell cell-cell junction anchoring junction cell junction intracellular organelle intracellular anatomical structure cytoskeleton organelle cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane apical part of cell cell-cell junction anchoring junction cell junction intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cell periphery basal part of cell plasma membrane basal plasma membrane plasma membrane region basolateral plasma membrane protein-containing complex extrinsic component of plasma membrane catenin complex plasma membrane protein complex membrane protein complex extrinsic component of membrane cytoplasm membrane raft plasma membrane raft caveola membrane microdomain flotillin complex synapse glutamatergic synapse apical junction complex adherens junction membrane-bounded organelle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment intracellular membrane-bounded organelle endomembrane system trans-Golgi network actin-based cell projection microvillus perinuclear region of cytoplasm axon neuron projection postsynapse main axon node of Ranvier cell surface compact myelin myelin sheath Schmidt-Lanterman incisure endosome intracellular vesicle cytoplasmic vesicle vesicle lateral plasma membrane lateral loop axon terminus presynapse distal axon neuron projection terminus cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR000225	Armadillo	Repeat
A, B	IPR013284	Beta-catenin	Family
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
C, D	IPR014868	Cadherin prodomain	Domain
C, D	IPR027397	Catenin binding domain superfamily	Homologous Superfamily
C, D	IPR015919	Cadherin-like superfamily	Homologous Superfamily
C, D	IPR039808	Cadherin	Family
C, D	IPR002126	Cadherin-like	Domain
C, D	IPR000233	Cadherin, Y-type LIR-motif	Domain
C, D	IPR020894	Cadherin conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P14923	arrhythmogenic right ventricular cardiomyopathy Naxos disease arrhythmogenic right ventricular dysplasia 12 palmoplantar keratosis lethal acantholytic epidermolysis bullosa prostate cancer liver disease No-Reflow Phenomenon cardiomyopathy non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor squamous cell carcinoma autosomal dominant cardiac arrhythmia (Kuhn) Charcot-Marie-Tooth disease arrhythmogenic right ventricular cardiomyopathy Naxos disease arrhythmogenic right ventricular dysplasia 12 palmoplantar keratosis lethal acantholytic epidermolysis bullosa prostate cancer liver disease No-Reflow Phenomenon cardiomyopathy non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor squamous cell carcinoma autosomal dominant cardiac arrhythmia (Kuhn) Charcot-Marie-Tooth disease epidermolysis bullosa lung adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm carcinoma of esophagus erythrokeratoderma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma pituitary cancer atypical teratoid rhabdoid tumor dilated cardiomyopathy interstitial cystitis medulloblastoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
C, D	SEP	Parent Component: SER RESID: AA0037 PSI-MOD : O-phospho-L-serine MOD:00046

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.