3IAS

Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus, oxidized, 4 mol/ASU, re-refined to 3.15 angstrom resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: mpstruc

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
Q [auth J]	d3iasj3	All alpha proteins	Bromodomain-like	Nqo1C-terminal domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
Q [auth J]	d3iasj1	Alpha and beta proteins (a/b)	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
Q [auth J]	d3iasj2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Nqo1 middle domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
A [auth 1]	d3ias13	All alpha proteins	Bromodomain-like	Nqo1C-terminal domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
A [auth 1]	d3ias11	Alpha and beta proteins (a/b)	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
A [auth 1]	d3ias12	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Nqo1 middle domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
I [auth A]	d3iasa3	All alpha proteins	Bromodomain-like	Nqo1C-terminal domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
I [auth A]	d3iasa1	Alpha and beta proteins (a/b)	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
I [auth A]	d3iasa2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Nqo1 middle domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
Y [auth S]	d3iass3	All alpha proteins	Bromodomain-like	Nqo1C-terminal domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
Y [auth S]	d3iass1	Alpha and beta proteins (a/b)	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	Nqo1 FMN-binding domain-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
Y [auth S]	d3iass2	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	Nqo1 middle domain-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
B [auth 2]	d3ias2_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	NQO2-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
R [auth K]	d3iask_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	NQO2-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
J [auth B]	d3iasb_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	NQO2-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
Z [auth T]	d3iast_	Alpha and beta proteins (a/b)	Thioredoxin fold	Thioredoxin-like	NQO2-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
K [auth C]	d3iasc4	All beta proteins	Double psi beta-barrel	ADC-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
K [auth C]	d3iasc3	Alpha and beta proteins (a/b)	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
K [auth C]	d3iasc1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
K [auth C]	d3iasc2	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
AA [auth U]	d3iasu4	All beta proteins	Double psi beta-barrel	ADC-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
AA [auth U]	d3iasu3	Alpha and beta proteins (a/b)	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
AA [auth U]	d3iasu1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
AA [auth U]	d3iasu2	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
C [auth 3]	d3ias34	All beta proteins	Double psi beta-barrel	ADC-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
C [auth 3]	d3ias33	Alpha and beta proteins (a/b)	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
C [auth 3]	d3ias31	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
C [auth 3]	d3ias32	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
S [auth L]	d3iasl4	All beta proteins	Double psi beta-barrel	ADC-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
S [auth L]	d3iasl3	Alpha and beta proteins (a/b)	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	Formate dehydrogenase/DMSO reductase, domains 1-3	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
S [auth L]	d3iasl1	Alpha and beta proteins (a+b)	beta-Grasp (ubiquitin-like)	2Fe-2S ferredoxin-like	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
S [auth L]	d3iasl2	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	automated matches	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
BA [auth V]	d3iasv_	Multi-domain proteins (alpha and beta)	HydB/Nqo4-like	HydB/Nqo4-like	Nqo4-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
D [auth 4]	d3ias4_	Multi-domain proteins (alpha and beta)	HydB/Nqo4-like	HydB/Nqo4-like	Nqo4-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
L [auth D]	d3iasd_	Multi-domain proteins (alpha and beta)	HydB/Nqo4-like	HydB/Nqo4-like	Nqo4-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
T [auth M]	d3iasm_	Multi-domain proteins (alpha and beta)	HydB/Nqo4-like	HydB/Nqo4-like	Nqo4-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
CA [auth W]	d3iasw_	Alpha and beta proteins (a+b)	Nqo5-like	Nqo5-like	Nqo5-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
E [auth 5]	d3ias5_	Alpha and beta proteins (a+b)	Nqo5-like	Nqo5-like	Nqo5-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
U [auth N]	d3iasn_	Alpha and beta proteins (a+b)	Nqo5-like	Nqo5-like	Nqo5-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
M [auth E]	d3iase_	Alpha and beta proteins (a+b)	Nqo5-like	Nqo5-like	Nqo5-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
N [auth F]	d3iasf_	Multi-domain proteins (alpha and beta)	HydA/Nqo6-like	HydA/Nqo6-like	Nq06-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
V [auth O]	d3iaso_	Multi-domain proteins (alpha and beta)	HydA/Nqo6-like	HydA/Nqo6-like	Nq06-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
DA [auth X]	d3iasx_	Multi-domain proteins (alpha and beta)	HydA/Nqo6-like	HydA/Nqo6-like	Nq06-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
F [auth 6]	d3ias6_	Multi-domain proteins (alpha and beta)	HydA/Nqo6-like	HydA/Nqo6-like	Nq06-like	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
EA [auth Y]	d3iasy_	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	Ferredoxin domains from multidomain proteins	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
O [auth G]	d3iasg_	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	Ferredoxin domains from multidomain proteins	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
W [auth P]	d3iasp_	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	Ferredoxin domains from multidomain proteins	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
G [auth 9]	d3ias9_	Alpha and beta proteins (a+b)	Ferredoxin-like	4Fe-4S ferredoxins	Ferredoxin domains from multidomain proteins	automated matches	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
FA [auth Z]	d3iasz_	Alpha and beta proteins (a+b)	N domain of copper amine oxidase-like	Frataxin/Nqo15-like	Nqo15-like	NADH-quinone oxidoreductase subunit 15, Nqo15	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
X [auth Q]	d3iasq_	Alpha and beta proteins (a+b)	N domain of copper amine oxidase-like	Frataxin/Nqo15-like	Nqo15-like	NADH-quinone oxidoreductase subunit 15, Nqo15	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
H [auth 7]	d3ias7_	Alpha and beta proteins (a+b)	N domain of copper amine oxidase-like	Frataxin/Nqo15-like	Nqo15-like	NADH-quinone oxidoreductase subunit 15, Nqo15	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)
P [auth H]	d3iash_	Alpha and beta proteins (a+b)	N domain of copper amine oxidase-like	Frataxin/Nqo15-like	Nqo15-like	NADH-quinone oxidoreductase subunit 15, Nqo15	(Thermus thermophilus HB8 ) [TaxId: 300852 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
Q [auth J]	SCOP2B Superfamily	Nqo1 FMN-binding domain-like	8041341	3001265	SCOP2B (2022-06-29)
Q [auth J]	SCOP2B Superfamily	Nqo1C-terminal domain-like	8041340	3001171	SCOP2B (2022-06-29)
Q [auth J]	SCOP2B Superfamily	Nqo1 middle domain-like	8041342	3000871	SCOP2B (2022-06-29)
A [auth 1]	SCOP2B Superfamily	Nqo1C-terminal domain-like	8041340	3001171	SCOP2B (2022-06-29)
A [auth 1]	SCOP2B Superfamily	Nqo1 middle domain-like	8041342	3000871	SCOP2B (2022-06-29)
A [auth 1]	SCOP2B Superfamily	Nqo1 FMN-binding domain-like	8041341	3001265	SCOP2B (2022-06-29)
I [auth A]	SCOP2B Superfamily	Nqo1 middle domain-like	8041342	3000871	SCOP2B (2022-06-29)
I [auth A]	SCOP2B Superfamily	Nqo1 FMN-binding domain-like	8041341	3001265	SCOP2B (2022-06-29)
I [auth A]	SCOP2B Superfamily	Nqo1C-terminal domain-like	8041340	3001171	SCOP2B (2022-06-29)
Y [auth S]	SCOP2B Superfamily	Nqo1 middle domain-like	8041342	3000871	SCOP2B (2022-06-29)
Y [auth S]	SCOP2B Superfamily	Nqo1 FMN-binding domain-like	8041341	3001265	SCOP2B (2022-06-29)
Y [auth S]	SCOP2B Superfamily	Nqo1C-terminal domain-like	8041340	3001171	SCOP2B (2022-06-29)
B [auth 2]	SCOP2B Superfamily	Thioredoxin-like	8041344	3000031	SCOP2B (2022-06-29)
R [auth K]	SCOP2B Superfamily	Thioredoxin-like	8041344	3000031	SCOP2B (2022-06-29)
J [auth B]	SCOP2B Superfamily	Thioredoxin-like	8041344	3000031	SCOP2B (2022-06-29)
Z [auth T]	SCOP2B Superfamily	Thioredoxin-like	8041344	3000031	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	ADC-like	8041345	3001132	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	Formate dehydrogenase/DMSO reductase domains 1-3	8041346	3001453	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8041347	3000113	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041348	3000020	SCOP2B (2022-06-29)
AA [auth U]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8041347	3000113	SCOP2B (2022-06-29)
AA [auth U]	SCOP2B Superfamily	Formate dehydrogenase/DMSO reductase domains 1-3	8041346	3001453	SCOP2B (2022-06-29)
AA [auth U]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041348	3000020	SCOP2B (2022-06-29)
AA [auth U]	SCOP2B Superfamily	ADC-like	8041345	3001132	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	Formate dehydrogenase/DMSO reductase domains 1-3	8041346	3001453	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	ADC-like	8041345	3001132	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8041347	3000113	SCOP2B (2022-06-29)
C [auth 3]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041348	3000020	SCOP2B (2022-06-29)
S [auth L]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041348	3000020	SCOP2B (2022-06-29)
S [auth L]	SCOP2B Superfamily	ADC-like	8041345	3001132	SCOP2B (2022-06-29)
S [auth L]	SCOP2B Superfamily	2Fe-2S ferredoxin-like	8041347	3000113	SCOP2B (2022-06-29)
S [auth L]	SCOP2B Superfamily	Formate dehydrogenase/DMSO reductase domains 1-3	8041346	3001453	SCOP2B (2022-06-29)
BA [auth V]	SCOP2B Superfamily	HydB/Nqo4-like	8041349	3001849	SCOP2B (2022-06-29)
D [auth 4]	SCOP2B Superfamily	HydB/Nqo4-like	8041349	3001849	SCOP2B (2022-06-29)
L [auth D]	SCOP2B Superfamily	HydB/Nqo4-like	8041349	3001849	SCOP2B (2022-06-29)
T [auth M]	SCOP2B Superfamily	HydB/Nqo4-like	8041349	3001849	SCOP2B (2022-06-29)
CA [auth W]	SCOP2B Superfamily	Nqo5-like	8041351	3001071	SCOP2B (2022-06-29)
E [auth 5]	SCOP2B Superfamily	Nqo5-like	8041351	3001071	SCOP2B (2022-06-29)
U [auth N]	SCOP2B Superfamily	Nqo5-like	8041351	3001071	SCOP2B (2022-06-29)
M [auth E]	SCOP2B Superfamily	Nqo5-like	8041351	3001071	SCOP2B (2022-06-29)
N [auth F]	SCOP2B Superfamily	Nqo6/HydA N-terminal domain-like	8041352	3002291	SCOP2B (2022-06-29)
V [auth O]	SCOP2B Superfamily	Nqo6/HydA N-terminal domain-like	8041352	3002291	SCOP2B (2022-06-29)
DA [auth X]	SCOP2B Superfamily	Nqo6/HydA N-terminal domain-like	8041352	3002291	SCOP2B (2022-06-29)
F [auth 6]	SCOP2B Superfamily	Nqo6/HydA N-terminal domain-like	8041352	3002291	SCOP2B (2022-06-29)
EA [auth Y]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041354	3000020	SCOP2B (2022-06-29)
O [auth G]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041354	3000020	SCOP2B (2022-06-29)
W [auth P]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041354	3000020	SCOP2B (2022-06-29)
G [auth 9]	SCOP2B Superfamily	4Fe-4S ferredoxins	8041354	3000020	SCOP2B (2022-06-29)
FA [auth Z]	SCOP2B Superfamily	Frataxin/Nqo15-like	8041353	3001840	SCOP2B (2022-06-29)
X [auth Q]	SCOP2B Superfamily	Frataxin/Nqo15-like	8041353	3001840	SCOP2B (2022-06-29)
H [auth 7]	SCOP2B Superfamily	Frataxin/Nqo15-like	8041353	3001840	SCOP2B (2022-06-29)
P [auth H]	SCOP2B Superfamily	Frataxin/Nqo15-like	8041353	3001840	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
Q [auth J]	NADH_4Fe-4S	e3iasJ1	A: alpha bundles	X: Bromodomain-like	H: Nqo1C-terminal domain-like (From Topology)	T: Nqo1C-terminal domain-like	F: NADH_4Fe-4S	ECOD (1.6)
Q [auth J]	SLBB	e3iasJ2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Nqo1 middle domain-like	F: SLBB	ECOD (1.6)
Q [auth J]	Complex1_51K	e3iasJ3	A: a/b three-layered sandwiches	X: Nqo1 FMN-binding domain-like (From Topology)	H: Nqo1 FMN-binding domain-like (From Topology)	T: Nqo1 FMN-binding domain-like	F: Complex1_51K	ECOD (1.6)
A [auth 1]	NADH_4Fe-4S	e3ias11	A: alpha bundles	X: Bromodomain-like	H: Nqo1C-terminal domain-like (From Topology)	T: Nqo1C-terminal domain-like	F: NADH_4Fe-4S	ECOD (1.6)
A [auth 1]	SLBB	e3ias12	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Nqo1 middle domain-like	F: SLBB	ECOD (1.6)
A [auth 1]	Complex1_51K	e3ias13	A: a/b three-layered sandwiches	X: Nqo1 FMN-binding domain-like (From Topology)	H: Nqo1 FMN-binding domain-like (From Topology)	T: Nqo1 FMN-binding domain-like	F: Complex1_51K	ECOD (1.6)
I [auth A]	NADH_4Fe-4S	e3iasA1	A: alpha bundles	X: Bromodomain-like	H: Nqo1C-terminal domain-like (From Topology)	T: Nqo1C-terminal domain-like	F: NADH_4Fe-4S	ECOD (1.6)
I [auth A]	SLBB	e3iasA2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Nqo1 middle domain-like	F: SLBB	ECOD (1.6)
I [auth A]	Complex1_51K	e3iasA3	A: a/b three-layered sandwiches	X: Nqo1 FMN-binding domain-like (From Topology)	H: Nqo1 FMN-binding domain-like (From Topology)	T: Nqo1 FMN-binding domain-like	F: Complex1_51K	ECOD (1.6)
Y [auth S]	NADH_4Fe-4S	e3iasS1	A: alpha bundles	X: Bromodomain-like	H: Nqo1C-terminal domain-like (From Topology)	T: Nqo1C-terminal domain-like	F: NADH_4Fe-4S	ECOD (1.6)
Y [auth S]	SLBB	e3iasS2	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Nqo1 middle domain-like	F: SLBB	ECOD (1.6)
Y [auth S]	Complex1_51K	e3iasS3	A: a/b three-layered sandwiches	X: Nqo1 FMN-binding domain-like (From Topology)	H: Nqo1 FMN-binding domain-like (From Topology)	T: Nqo1 FMN-binding domain-like	F: Complex1_51K	ECOD (1.6)
B [auth 2]	2Fe-2S_thioredx_N	e3ias22	A: alpha bundles	X: NQO2 helical bundle domain (From Topology)	H: NQO2 helical bundle domain (From Topology)	T: NQO2 helical bundle domain	F: 2Fe-2S_thioredx_N	ECOD (1.6)
B [auth 2]	2Fe-2S_thioredx_C	e3ias21	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: 2Fe-2S_thioredx_C	ECOD (1.6)
R [auth K]	2Fe-2S_thioredx_N	e3iasK2	A: alpha bundles	X: NQO2 helical bundle domain (From Topology)	H: NQO2 helical bundle domain (From Topology)	T: NQO2 helical bundle domain	F: 2Fe-2S_thioredx_N	ECOD (1.6)
R [auth K]	2Fe-2S_thioredx_C	e3iasK1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: 2Fe-2S_thioredx_C	ECOD (1.6)
J [auth B]	2Fe-2S_thioredx_N	e3iasB2	A: alpha bundles	X: NQO2 helical bundle domain (From Topology)	H: NQO2 helical bundle domain (From Topology)	T: NQO2 helical bundle domain	F: 2Fe-2S_thioredx_N	ECOD (1.6)
J [auth B]	2Fe-2S_thioredx_C	e3iasB1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: 2Fe-2S_thioredx_C	ECOD (1.6)
Z [auth T]	2Fe-2S_thioredx_N	e3iasT2	A: alpha bundles	X: NQO2 helical bundle domain (From Topology)	H: NQO2 helical bundle domain (From Topology)	T: NQO2 helical bundle domain	F: 2Fe-2S_thioredx_N	ECOD (1.6)
Z [auth T]	2Fe-2S_thioredx_C	e3iasT1	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: 2Fe-2S_thioredx_C	ECOD (1.6)
K [auth C]	Molydop_binding	e3iasC8	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Molydop_binding	ECOD (1.6)
K [auth C]	PRK09129	e3iasC7	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PRK09129	ECOD (1.6)
K [auth C]	Fer2_4	e3iasC4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_4	ECOD (1.6)
K [auth C]	Molybdop_Fe4S4	e3iasC10	A: a+b two layers	X: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	H: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domain 1	F: Molybdop_Fe4S4	ECOD (1.6)
K [auth C]	Molybdopterin_2nd	e3iasC6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: Molybdopterin_2nd	ECOD (1.6)
K [auth C]	NuoG_2nd	e3iasC5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: NuoG_2nd	ECOD (1.6)
K [auth C]	NADH-G_4Fe-4S_3	e3iasC9	A: extended segments	X: iron-sulfur center-binding helical hairpin (From Topology)	H: iron-sulfur center-binding helical hairpin (From Topology)	T: iron-sulfur center-binding helical hairpin	F: NADH-G_4Fe-4S_3	ECOD (1.6)
AA [auth U]	Molydop_binding	e3iasU8	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Molydop_binding	ECOD (1.6)
AA [auth U]	PRK09129	e3iasU7	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PRK09129	ECOD (1.6)
AA [auth U]	Fer2_4	e3iasU4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_4	ECOD (1.6)
AA [auth U]	Molybdop_Fe4S4	e3iasU10	A: a+b two layers	X: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	H: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domain 1	F: Molybdop_Fe4S4	ECOD (1.6)
AA [auth U]	Molybdopterin_2nd	e3iasU6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: Molybdopterin_2nd	ECOD (1.6)
AA [auth U]	NuoG_2nd	e3iasU5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: NuoG_2nd	ECOD (1.6)
AA [auth U]	NADH-G_4Fe-4S_3	e3iasU9	A: extended segments	X: iron-sulfur center-binding helical hairpin (From Topology)	H: iron-sulfur center-binding helical hairpin (From Topology)	T: iron-sulfur center-binding helical hairpin	F: NADH-G_4Fe-4S_3	ECOD (1.6)
C [auth 3]	Molydop_binding	e3ias38	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Molydop_binding	ECOD (1.6)
C [auth 3]	PRK09129	e3ias37	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PRK09129	ECOD (1.6)
C [auth 3]	Fer2_4	e3ias34	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_4	ECOD (1.6)
C [auth 3]	Molybdop_Fe4S4	e3ias310	A: a+b two layers	X: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	H: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domain 1	F: Molybdop_Fe4S4	ECOD (1.6)
C [auth 3]	Molybdopterin_2nd	e3ias36	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: Molybdopterin_2nd	ECOD (1.6)
C [auth 3]	NuoG_2nd	e3ias35	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: NuoG_2nd	ECOD (1.6)
C [auth 3]	NADH-G_4Fe-4S_3	e3ias39	A: extended segments	X: iron-sulfur center-binding helical hairpin (From Topology)	H: iron-sulfur center-binding helical hairpin (From Topology)	T: iron-sulfur center-binding helical hairpin	F: NADH-G_4Fe-4S_3	ECOD (1.6)
S [auth L]	Molydop_binding	e3iasL8	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: Molydop_binding	ECOD (1.6)
S [auth L]	PRK09129	e3iasL7	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PRK09129	ECOD (1.6)
S [auth L]	Fer2_4	e3iasL4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2_4	ECOD (1.6)
S [auth L]	Molybdop_Fe4S4	e3iasL10	A: a+b two layers	X: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	H: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domain 1	F: Molybdop_Fe4S4	ECOD (1.6)
S [auth L]	Molybdopterin_2nd	e3iasL6	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: Molybdopterin_2nd	ECOD (1.6)
S [auth L]	NuoG_2nd	e3iasL5	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: NuoG_2nd	ECOD (1.6)
S [auth L]	NADH-G_4Fe-4S_3	e3iasL9	A: extended segments	X: iron-sulfur center-binding helical hairpin (From Topology)	H: iron-sulfur center-binding helical hairpin (From Topology)	T: iron-sulfur center-binding helical hairpin	F: NADH-G_4Fe-4S_3	ECOD (1.6)
BA [auth V]	Complex1_49kDa_1st	e3iasV6	A: alpha complex topology	X: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	H: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	T: alpha-helical domain in nickel-iron hydrogenase, large subunit	F: Complex1_49kDa_1st	ECOD (1.6)
BA [auth V]	NuoD	e3iasV5	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: NuoD	ECOD (1.6)
BA [auth V]	Complex1_49kDa_2nd	e3iasV4	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: Complex1_49kDa_2nd	ECOD (1.6)
D [auth 4]	Complex1_49kDa_1st	e3ias46	A: alpha complex topology	X: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	H: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	T: alpha-helical domain in nickel-iron hydrogenase, large subunit	F: Complex1_49kDa_1st	ECOD (1.6)
D [auth 4]	NuoD	e3ias45	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: NuoD	ECOD (1.6)
D [auth 4]	Complex1_49kDa_2nd	e3ias44	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: Complex1_49kDa_2nd	ECOD (1.6)
L [auth D]	Complex1_49kDa_1st	e3iasD6	A: alpha complex topology	X: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	H: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	T: alpha-helical domain in nickel-iron hydrogenase, large subunit	F: Complex1_49kDa_1st	ECOD (1.6)
L [auth D]	NuoD	e3iasD5	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: NuoD	ECOD (1.6)
L [auth D]	Complex1_49kDa_2nd	e3iasD4	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: Complex1_49kDa_2nd	ECOD (1.6)
T [auth M]	Complex1_49kDa_1st	e3iasM6	A: alpha complex topology	X: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	H: alpha-helical domain in nickel-iron hydrogenase, large subunit (From Topology)	T: alpha-helical domain in nickel-iron hydrogenase, large subunit	F: Complex1_49kDa_1st	ECOD (1.6)
T [auth M]	NuoD	e3iasM5	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: NuoD	ECOD (1.6)
T [auth M]	Complex1_49kDa_2nd	e3iasM4	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: Ni-Fe binding domain in nickel-iron hydrogenase large subunit (From Topology)	T: Ni-Fe binding domain in nickel-iron hydrogenase large subunit	F: Complex1_49kDa_2nd	ECOD (1.6)
CA [auth W]	Complex1_30kDa	e3iasW1	A: a+b two layers	X: Nqo5-like	H: Nqo5-like (From Topology)	T: Nqo5-like	F: Complex1_30kDa	ECOD (1.6)
E [auth 5]	Complex1_30kDa	e3ias51	A: a+b two layers	X: Nqo5-like	H: Nqo5-like (From Topology)	T: Nqo5-like	F: Complex1_30kDa	ECOD (1.6)
U [auth N]	Complex1_30kDa	e3iasN1	A: a+b two layers	X: Nqo5-like	H: Nqo5-like (From Topology)	T: Nqo5-like	F: Complex1_30kDa	ECOD (1.6)
M [auth E]	Complex1_30kDa	e3iasE1	A: a+b two layers	X: Nqo5-like	H: Nqo5-like (From Topology)	T: Nqo5-like	F: Complex1_30kDa	ECOD (1.6)
N [auth F]	Oxidored_q6	e3iasF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: Oxidored_q6	ECOD (1.6)
V [auth O]	Oxidored_q6	e3iasO1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: Oxidored_q6	ECOD (1.6)
DA [auth X]	Oxidored_q6	e3iasX1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: Oxidored_q6	ECOD (1.6)
F [auth 6]	Oxidored_q6	e3ias61	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: Oxidored_q6	ECOD (1.6)
EA [auth Y]	Fer4_21_1	e3iasY1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_21_1	ECOD (1.6)
O [auth G]	Fer4_21_1	e3iasG1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_21_1	ECOD (1.6)
W [auth P]	Fer4_21_1	e3iasP1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_21_1	ECOD (1.6)
G [auth 9]	Fer4_21_1	e3ias91	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: Fer4_21_1	ECOD (1.6)
FA [auth Z]	NADH_Oxid_Nqo15	e3iasZ1	A: a+b two layers	X: Type III secretory system chaperone-like	H: Frataxin-like (From Topology)	T: Frataxin-like	F: NADH_Oxid_Nqo15	ECOD (1.6)
X [auth Q]	NADH_Oxid_Nqo15	e3iasQ1	A: a+b two layers	X: Type III secretory system chaperone-like	H: Frataxin-like (From Topology)	T: Frataxin-like	F: NADH_Oxid_Nqo15	ECOD (1.6)
H [auth 7]	NADH_Oxid_Nqo15	e3ias71	A: a+b two layers	X: Type III secretory system chaperone-like	H: Frataxin-like (From Topology)	T: Frataxin-like	F: NADH_Oxid_Nqo15	ECOD (1.6)
P [auth H]	NADH_Oxid_Nqo15	e3iasH1	A: a+b two layers	X: Type III secretory system chaperone-like	H: Frataxin-like (From Topology)	T: Frataxin-like	F: NADH_Oxid_Nqo15	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
Q [auth J]	6.10.250.1450	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
Q [auth J]	3.40.50.11540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NADH-ubiquinone oxidoreductase 51kDa subunit	CATH (4.3.0)
Q [auth J]	3.10.20.600	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
Q [auth J]	1.20.1440.230	Mainly Alpha	Up-down Bundle	de novo design (two linked rop proteins)	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	CATH (4.3.0)
A [auth 1]	6.10.250.1450	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A [auth 1]	3.40.50.11540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NADH-ubiquinone oxidoreductase 51kDa subunit	CATH (4.3.0)
A [auth 1]	3.10.20.600	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
A [auth 1]	1.20.1440.230	Mainly Alpha	Up-down Bundle	de novo design (two linked rop proteins)	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	CATH (4.3.0)
I [auth A]	6.10.250.1450	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
I [auth A]	3.40.50.11540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NADH-ubiquinone oxidoreductase 51kDa subunit	CATH (4.3.0)
I [auth A]	3.10.20.600	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
I [auth A]	1.20.1440.230	Mainly Alpha	Up-down Bundle	de novo design (two linked rop proteins)	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	CATH (4.3.0)
Y [auth S]	6.10.250.1450	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
Y [auth S]	3.40.50.11540	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NADH-ubiquinone oxidoreductase 51kDa subunit	CATH (4.3.0)
Y [auth S]	3.10.20.600	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (4.3.0)
Y [auth S]	1.20.1440.230	Mainly Alpha	Up-down Bundle	de novo design (two linked rop proteins)	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	CATH (4.3.0)
B [auth 2]	1.10.10.1590	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	NADH-quinone oxidoreductase subunit E	CATH (4.3.0)
B [auth 2]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
R [auth K]	1.10.10.1590	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	NADH-quinone oxidoreductase subunit E	CATH (4.3.0)
R [auth K]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
J [auth B]	1.10.10.1590	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	NADH-quinone oxidoreductase subunit E	CATH (4.3.0)
J [auth B]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
Z [auth T]	1.10.10.1590	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	NADH-quinone oxidoreductase subunit E	CATH (4.3.0)
Z [auth T]	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
BA [auth V]	1.10.645.10	Mainly Alpha	Orthogonal Bundle	Cytochrome-c3 Hydrogenase	chain B	CATH (4.3.0)
D [auth 4]	1.10.645.10	Mainly Alpha	Orthogonal Bundle	Cytochrome-c3 Hydrogenase	chain B	CATH (4.3.0)
L [auth D]	1.10.645.10	Mainly Alpha	Orthogonal Bundle	Cytochrome-c3 Hydrogenase	chain B	CATH (4.3.0)
T [auth M]	1.10.645.10	Mainly Alpha	Orthogonal Bundle	Cytochrome-c3 Hydrogenase	chain B	CATH (4.3.0)
N [auth F]	3.40.50.12280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
V [auth O]	3.40.50.12280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
DA [auth X]	3.40.50.12280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
F [auth 6]	3.40.50.12280	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
EA [auth Y]	3.30.70.3270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
O [auth G]	3.30.70.3270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
W [auth P]	3.30.70.3270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
G [auth 9]	3.30.70.3270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
FA [auth Z]	3.30.920.80	Alpha Beta	2-Layer Sandwich	Metal Transport, Frataxin	Chain A	CATH (4.3.0)
X [auth Q]	3.30.920.80	Alpha Beta	2-Layer Sandwich	Metal Transport, Frataxin	Chain A	CATH (4.3.0)
H [auth 7]	3.30.920.80	Alpha Beta	2-Layer Sandwich	Metal Transport, Frataxin	Chain A	CATH (4.3.0)
P [auth H]	3.30.920.80	Alpha Beta	2-Layer Sandwich	Metal Transport, Frataxin	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 1], I [auth A], Q [auth J], Y [auth S]	PF10531	SLBB domain (SLBB)	SLBB domain	-	Domain
A [auth 1], I [auth A], Q [auth J], Y [auth S]	PF01512	Respiratory-chain NADH dehydrogenase 51 Kd subunit (Complex1_51K)	Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	Family
A [auth 1], I [auth A], Q [auth J], Y [auth S]	PF10589	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region (NADH_4Fe-4S)	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	Domain
B [auth 2], J [auth B], R [auth K], Z [auth T]	PF01257	Thioredoxin-like [2Fe-2S] ferredoxin (2Fe-2S_thioredx)	Thioredoxin-like [2Fe-2S] ferredoxin	-	Family
AA [auth U], C [auth 3], K [auth C], S [auth L]	PF01568	Molydopterin dinucleotide binding domain (Molydop_binding)	Molydopterin dinucleotide binding domain	This domain is found in various molybdopterin - containing oxidoreductases and tungsten formylmethanofuran dehydrogenase subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase subunit (FmdD); where the domain constitutes almost the entir ...	This domain is found in various molybdopterin - containing oxidoreductases and tungsten formylmethanofuran dehydrogenase subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase subunit (FmdD); where the domain constitutes almost the entire subunit. The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a molybdopterin dinucleotide cofactor [1]. This domain corresponds to the C-terminal domain IV in dimethyl sulfoxide (DMSO)reductase which interacts with the 2-amino pyrimidone ring of both molybdopterin guanine dinucleotide molecules [2].	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	PF04879	Molybdopterin oxidoreductase Fe4S4 domain (Molybdop_Fe4S4)	Molybdopterin oxidoreductase Fe4S4 domain	This domain is found in formate dehydrogenase H for which the structure is known. This first domain (residues 1 to 60) of PDB:1aa6 is an Fe4S4 cluster just below the protein surface [1].	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	PF00384	Molybdopterin oxidoreductase (Molybdopterin)	Molybdopterin oxidoreductase	-	Family
AA [auth U], C [auth 3], K [auth C], S [auth L]	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	PF10588	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region (NADH-G_4Fe-4S_3)	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	Domain
BA [auth V], D [auth 4], L [auth D], T [auth M]	PF00346	Respiratory-chain NADH dehydrogenase, 49 Kd subunit (Complex1_49kDa)	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	Family
CA [auth W], E [auth 5], M [auth E], U [auth N]	PF00329	Respiratory-chain NADH dehydrogenase, 30 Kd subunit (Complex1_30kDa)	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	Family
DA [auth X], F [auth 6], N [auth F], V [auth O]	PF01058	NADH ubiquinone oxidoreductase, 20 Kd subunit (Oxidored_q6)	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	Family
EA [auth Y], G [auth 9], O [auth G], W [auth P]	PF00037	4Fe-4S binding domain (Fer4)	4Fe-4S binding domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.	Domain
FA [auth Z], H [auth 7], P [auth H], X [auth Q]	PF11497	NADH-quinone oxidoreductase chain 15 (NADH_Oxid_Nqo15)	NADH-quinone oxidoreductase chain 15	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1], I [auth A], Q [auth J], Y [auth S]	NADH-quinone oxidoreductase subunit 1	binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding NAD binding purine nucleotide binding adenyl nucleotide binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding cation binding metal ion binding	-	respiratory chain complex protein-containing complex catalytic complex membrane membrane protein complex cellular anatomical entity transporter complex NADH dehydrogenase complex transmembrane transporter complex respiratory chain complex I respirasome oxidoreductase complex cell periphery plasma membrane
B [auth 2], J [auth B], R [auth K], Z [auth T]	NADH-quinone oxidoreductase subunit 2	oxidoreductase activity catalytic activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding quinone binding	-	cell periphery plasma membrane membrane cellular anatomical entity
AA [auth U], C [auth 3], K [auth C], S [auth L]	NADH-quinone oxidoreductase subunit 3	iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding organic cyclic compound binding iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding organic cyclic compound binding molybdopterin cofactor binding 4 iron, 4 sulfur cluster binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy respiratory electron transport chain metabolic process cellular process	cell periphery plasma membrane membrane cellular anatomical entity
BA [auth V], D [auth 4], L [auth D], T [auth M]	NADH-quinone oxidoreductase subunit 4	NAD binding binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NAD binding binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity quinone binding	-	cell periphery plasma membrane membrane cellular anatomical entity
CA [auth W], E [auth 5], M [auth E], U [auth N]	NADH-quinone oxidoreductase subunit 5	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding	-	cell periphery plasma membrane membrane cellular anatomical entity
DA [auth X], F [auth 6], N [auth F], V [auth O]	NADH-quinone oxidoreductase subunit 6	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding	-	cell periphery plasma membrane membrane cellular anatomical entity
EA [auth Y], G [auth 9], O [auth G], W [auth P]	NADH-quinone oxidoreductase subunit 9	iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding transition metal ion binding iron ion binding ion binding metal ion binding oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity quinone binding	-	cell periphery plasma membrane membrane cellular anatomical entity
FA [auth Z], H [auth 7], P [auth H], X [auth Q]	NADH-quinone oxidoreductase subunit 15	cation binding ferric iron binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding quinone binding	cellular component biogenesis cellular component organization metallo-sulfur cluster assembly cellular component assembly iron-sulfur cluster assembly cellular process cellular component organization or biogenesis	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR019575	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	Domain
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR019554	Soluble ligand binding domain	Domain
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR011537	NADH ubiquinone oxidoreductase, F subunit	Family
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR001949	NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site	Conserved Site
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily	Homologous Superfamily
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR037207	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily	Homologous Superfamily
A [auth 1], I [auth A], Q [auth J], Y [auth S]	IPR011538	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain	Domain
B [auth 2], J [auth B], R [auth K], Z [auth T]	IPR042128	NuoE domain	Domain
B [auth 2], J [auth B], R [auth K], Z [auth T]	IPR002023	NADH-quinone oxidoreductase subunit E-like	Family
B [auth 2], J [auth B], R [auth K], Z [auth T]	IPR041921	NADH-quinone oxidoreductase subunit E, N-terminal	Homologous Superfamily
B [auth 2], J [auth B], R [auth K], Z [auth T]	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR006963	Molybdopterin oxidoreductase, 4Fe-4S domain	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR006657	Molybdopterin dinucleotide-binding domain	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR001387	Cro/C1-type helix-turn-helix domain	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR006656	Molybdopterin oxidoreductase	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR000283	NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site	Conserved Site
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR010228	NADH:ubiquinone oxidoreductase, subunit G	Family
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily
AA [auth U], C [auth 3], K [auth C], S [auth L]	IPR019574	NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding	Domain
BA [auth V], D [auth 4], L [auth D], T [auth M]	IPR022885	NAD(P)H-quinone oxidoreductase subunit D/H	Family
BA [auth V], D [auth 4], L [auth D], T [auth M]	IPR014029	NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site	Conserved Site
BA [auth V], D [auth 4], L [auth D], T [auth M]	IPR029014	[NiFe]-hydrogenase, large subunit	Homologous Superfamily
BA [auth V], D [auth 4], L [auth D], T [auth M]	IPR001135	NADH-quinone oxidoreductase, subunit D	Domain
CA [auth W], E [auth 5], M [auth E], U [auth N]	IPR037232	NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily	Homologous Superfamily
CA [auth W], E [auth 5], M [auth E], U [auth N]	IPR001268	NADH:ubiquinone oxidoreductase, 30kDa subunit	Domain
CA [auth W], E [auth 5], M [auth E], U [auth N]	IPR020396	NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site	Conserved Site
CA [auth W], E [auth 5], M [auth E], U [auth N]	IPR010218	NADH dehydrogenase, subunit C	Family
DA [auth X], F [auth 6], N [auth F], V [auth O]	IPR006138	NADH-ubiquinone oxidoreductase, 20 Kd subunit	Family
DA [auth X], F [auth 6], N [auth F], V [auth O]	IPR006137	NADH:ubiquinone oxidoreductase-like, 20kDa subunit	Domain
EA [auth Y], G [auth 9], O [auth G], W [auth P]	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
EA [auth Y], G [auth 9], O [auth G], W [auth P]	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain
EA [auth Y], G [auth 9], O [auth G], W [auth P]	IPR010226	NADH-quinone oxidoreductase, chain I	Family
FA [auth Z], H [auth 7], P [auth H], X [auth Q]	IPR021093	NADH-quinone oxidoreductase, subunit15	Family
FA [auth Z], H [auth 7], P [auth H], X [auth Q]	IPR038458	NADH-quinone oxidoreductase, subunit 15 superfamily	Homologous Superfamily
FA [auth Z], H [auth 7], P [auth H], X [auth Q]	IPR036524	Frataxin/CyaY superfamily	Homologous Superfamily

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth 1], AA [auth U], B [auth 2], BA [auth V], C [auth 3] A [auth 1], AA [auth U], B [auth 2], BA [auth V], C [auth 3], CA [auth W], D [auth 4], DA [auth X], E [auth 5], EA [auth Y], F [auth 6], FA [auth Z], G [auth 9], H [auth 7], I [auth A], J [auth B], K [auth C], L [auth D], M [auth E], N [auth F], O [auth G], P [auth H], Q [auth J], R [auth K], S [auth L], T [auth M], U [auth N], V [auth O], W [auth P], X [auth Q], Y [auth S], Z [auth T]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Electron Transport Chain Complexes: Complex I	Complex I soluble domain, oxidized (2 mol/ASU)