Annotations: 3I4T

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Tetrapyrrole methylase	8064085	4000056	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Tetrapyrrole methylase	8064086	3000017	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e3i4tA2	A: a+b two layers	X: Tetrapyrrole methylase C-terminal domain-like	H: Tetrapyrrole methylase C-terminal domain (From Topology)	T: Tetrapyrrole methylase C-terminal domain	F: F_UNCLASSIFIED	ECOD (1.6)
A	PF00590	e3i4tA1	A: a/b three-layered sandwiches	X: Tetrapyrrole methylase N-terminal domain (From Topology)	H: Tetrapyrrole methylase N-terminal domain (From Topology)	T: Tetrapyrrole methylase N-terminal domain	F: PF00590	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.1010.10	Alpha Beta	3-Layer(aba) Sandwich	Cobalt-precorrin-4 Transmethylase	domain 1	CATH (4.3.0)
A	3.30.950.10	Alpha Beta	2-Layer Sandwich	Methyltransferase, Cobalt-precorrin-4 Transmethylase	Domain 2	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00590	Tetrapyrrole (Corrin/Porphyrin) Methylases (TP_methylase)	Tetrapyrrole (Corrin/Porphyrin) Methylases	This family uses S-AdoMet in the methylation of diverse substrates. This family includes a related group of bacterial proteins of unknown function, including Swiss:P45528. This family includes the methylase Dipthine synthase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	diphthine synthase	catalytic activity, acting on a protein diphthine synthase activity transferase activity, transferring one-carbon groups protein methyltransferase activity transferase activity methyltransferase activity catalytic activity S-adenosylmethionine-dependent methyltransferase activity	methylation metabolic process organonitrogen compound metabolic process primary metabolic process protein histidyl modification to diphthamide organic substance metabolic process peptidyl-histidine modification macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035996	Tetrapyrrole methylase superfamily	Homologous Superfamily
A	IPR014777	Tetrapyrrole methylase, subdomain 1	Homologous Superfamily
A	IPR014776	Tetrapyrrole methylase, subdomain 2	Homologous Superfamily
A	IPR000878	Tetrapyrrole methylase	Domain
A	IPR004551	Diphthine synthase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.