3I4A

Crystal structure of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) in complex with N5-(1-iminopropyl)-L-ornithine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3i4aa_	Alpha and beta proteins (a+b)	Pentein, beta/alpha-propeller	Pentein	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3i4ab_	Alpha and beta proteins (a+b)	Pentein, beta/alpha-propeller	Pentein	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Pentein	8088812	3000640	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Pentein	8088812	3000640	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF19420	e3i4aA1	A: a+b duplicates or obligate multimers	X: Pentein (From Topology)	H: Pentein (From Topology)	T: Pentein	F: PF19420	ECOD (1.6)
B	PF19420	e3i4aB1	A: a+b duplicates or obligate multimers	X: Pentein (From Topology)	H: Pentein (From Topology)	T: Pentein	F: PF19420	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.75.10.10	Alpha Beta	5-stranded Propeller	L-arginine/glycine Amidinotransferase	Chain A	CATH (4.3.0)
B	3.75.10.10	Alpha Beta	5-stranded Propeller	L-arginine/glycine Amidinotransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF19420	N,N dimethylarginine dimethylhydrolase, eukaryotic (DDAH_eukar)	N,N dimethylarginine dimethylhydrolase, eukaryotic	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	dimethylargininase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds binding amino acid binding cation binding ion binding metal ion binding small molecule binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process organonitrogen compound metabolic process oxoacid metabolic process cellular metabolic process carboxylic acid metabolic process amino acid metabolic process primary metabolic process organic acid metabolic process alpha-amino acid metabolic process non-proteinogenic amino acid metabolic process organic substance metabolic process small molecule metabolic process cellular process citrulline metabolic process negative regulation of cell population proliferation cell population proliferation regulation of cellular process regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process cellular response to stimulus nitric oxide mediated signal transduction response to stimulus signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction multicellular organismal process regulation of developmental process angiogenesis regulation of vasculature development positive regulation of developmental process multicellular organism development tube morphogenesis anatomical structure development regulation of multicellular organismal process regulation of anatomical structure morphogenesis blood vessel development system development developmental process regulation of multicellular organismal development blood vessel morphogenesis tube development positive regulation of angiogenesis vasculature development circulatory system development anatomical structure morphogenesis positive regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis positive regulation of multicellular organismal process system process regulation of systemic arterial blood pressure circulatory system process regulation of blood pressure regulation of biological quality blood circulation catabolic process glutamine family amino acid catabolic process arginine catabolic process organic acid catabolic process glutamine family amino acid metabolic process cellular catabolic process arginine metabolic process carboxylic acid catabolic process amino acid catabolic process organonitrogen compound catabolic process L-amino acid catabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process small molecule catabolic process organic substance catabolic process negative regulation of vascular permeability regulation of vascular permeability vascular process in circulatory system regulation of cellular response to hypoxia cellular response to oxygen levels cellular response to hypoxia regulation of cellular response to stress cellular response to decreased oxygen levels cellular response to stress regulation of response to stress response to stress response to decreased oxygen levels negative regulation of response to stimulus negative regulation of cellular response to hypoxia cellular response to chemical stimulus regulation of response to stimulus response to hypoxia response to chemical response to oxygen levels response to abiotic stimulus	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR033199	Dimethylarginine dimethylaminohydrolase-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O94760	liver disease sinusitis adrenal cortex carcinoma cystic fibrosis interstitial cystitis Liver Dysfunction nephrosclerosis ovarian cancer progressive supranuclear palsy Alzheimer disease esophageal adenocarcinoma large cell medulloblastoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm liver disease sinusitis adrenal cortex carcinoma cystic fibrosis interstitial cystitis Liver Dysfunction nephrosclerosis ovarian cancer progressive supranuclear palsy Alzheimer disease esophageal adenocarcinoma large cell medulloblastoma lung cancer non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis astrocytic tumor glioblastoma medulloblastoma oligodendroglioma Pick disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.