3I3J

Crystal Structure of the Bromodomain of Human EP300

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3i3ja_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3i3jb_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3i3jc_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3i3jd_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3i3je_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d3i3jf_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d3i3jh_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d3i3ji_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d3i3jj_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d3i3jk_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d3i3jl_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d3i3jg_	All alpha proteins	Bromodomain-like	Bromodomain	Bromodomain	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
B	SCOP2 Family	Bromodomain	8084258	4000871	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	Bromodomain	8084259	3001843	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Bromodomain	8084259	3001843	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bromodomain	e3i3jA1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
B	Bromodomain	e3i3jB1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
C	Bromodomain	e3i3jC1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
D	Bromodomain	e3i3jD1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
E	Bromodomain	e3i3jE1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
F	Bromodomain	e3i3jF1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
H	Bromodomain	e3i3jH1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
I	Bromodomain	e3i3jI1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
J	Bromodomain	e3i3jJ1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
K	Bromodomain	e3i3jK1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
L	Bromodomain	e3i3jL1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
G	Bromodomain	e3i3jG1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
B	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
C	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
D	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
E	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
F	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
H	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
I	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
J	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
K	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
L	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
G	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00439	Bromodomain (Bromodomain)	Bromodomain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF06001	CREB-binding protein/p300, atypical RING domain (RING_CBP-p300)	CREB-binding protein/p300, atypical RING domain	CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CB ...	CBP (CREB-binding protein) and p300 (also known as CREBBP or KAT3A and EP300 or KAT3B, respectively) are two histone acetyltransferases (HATs) that associate with and acetylate transcriptional regulators and chromatin. The catalytic core of animal CBP-p300 contains a bromodomain, a CH2 region containing a discontinuous PHD domain interrupted by this RING domain, and a HAT domain. Bromodomain-RING-PHD forms a compact module in which the RING domain is juxtaposed with the HAT substrate-binding site. This RING domain contains only a single zinc ion-binding cluster instead of two; instead of a second zinc atom, a network of hydrophobic interactions stabilizes the domain. The RING domain has an inhibitory role. Disease mutations that disrupt RING attachment lead to upregulation of HAT activity. HAT regulation may require repositioning of the RING domain to facilitate access to an otherwise partially occluded HAT active site. Plant CBP-p300 type HATs lack a bromodomain whose role in the animal animal CBP-p300's is to bind acetylated histones; it has been suggested that these plant proteins may utilise a different domain or another bromodomain protein to perform this function [1]. This RING domain has also been referred to as DUF902.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Histone acetyltransferase p300	acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity peptide 2-hydroxyisobutyryltransferase activity N-acyltransferase activity DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on a protein histone butyryltransferase activity peptide butyryltransferase activity acetyltransferase activity acyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity peptide 2-hydroxyisobutyryltransferase activity N-acyltransferase activity DNA binding binding organic cyclic compound binding nucleic acid binding catalytic activity, acting on a protein histone butyryltransferase activity peptide butyryltransferase activity histone modifying activity N-acetyltransferase activity histone H3 acetyltransferase activity peptide N-acetyltransferase activity histone acetyltransferase activity peptide-lysine-N-acetyltransferase activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding DNA-binding transcription factor binding nuclear androgen receptor binding histone lactyltransferase activity peptide lactyltransferase activity transcription coregulator binding transcription coactivator binding protein-containing complex binding chromatin binding chromatin DNA binding beta-catenin binding NF-kappaB binding histone H3K122 acetyltransferase activity STAT family protein binding histone H2B acetyltransferase activity cytoskeletal protein binding tau protein binding peptide crotonyltransferase activity histone crotonyltransferase activity lysine N-acetyltransferase activity, acting on acetyl phosphate as donor histone H3K27 acetyltransferase activity protein propionyltransferase activity pre-mRNA binding RNA binding pre-mRNA intronic binding p53 binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity damaged DNA binding modification-dependent protein binding acetylation-dependent protein binding histone H3K18 acetyltransferase activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding histone H4 acetyltransferase activity	cellular response to acid chemical cellular response to stimulus cellular response to nitrogen compound cellular response to amino acid stimulus response to organic substance response to stimulus response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to L-leucine cellular response to oxygen-containing compound cellular response to endogenous stimulus response to acid chemical cellular response to acid chemical cellular response to stimulus cellular response to nitrogen compound cellular response to amino acid stimulus response to organic substance response to stimulus response to organonitrogen compound response to endogenous stimulus response to oxygen-containing compound response to nitrogen compound response to amino acid cellular response to L-leucine cellular response to oxygen-containing compound cellular response to endogenous stimulus response to acid chemical cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular process cellular response to organic substance response to L-leucine developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development regulation of protein stability biological regulation regulation of biological quality protein stabilization behavior thigmotaxis regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription transcription by RNA polymerase II chromatin organization organic substance biosynthetic process positive regulation of macromolecule metabolic process transcription initiation at RNA polymerase II promoter regulation of biological process cellular metabolic process regulation of cellular metabolic process primary metabolic process regulation of gene expression organic cyclic compound metabolic process biosynthetic process organic cyclic compound biosynthetic process transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process protein-DNA complex organization cellular component organization RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process chromatin remodeling cellular component organization or biogenesis positive regulation of cellular process regulation of biosynthetic process protein-containing complex organization epigenetic regulation of gene expression regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of cellular biosynthetic process positive regulation of gene expression positive regulation of cellular biosynthetic process peptidyl-lysine acetylation organonitrogen compound metabolic process peptidyl-lysine modification protein acylation protein acetylation macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process positive regulation of DNA-binding transcription factor activity regulation of primary metabolic process positive regulation of molecular function regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription apoptotic process cell death programmed cell death ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process purine ribonucleotide catabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process organonitrogen compound catabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process purine nucleoside triphosphate metabolic process carbohydrate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process organic cyclic compound catabolic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process purine ribonucleoside diphosphate metabolic process organic substance catabolic process purine ribonucleoside diphosphate catabolic process regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cellular developmental process cell projection organization cell development neuron projection development neurogenesis neuron differentiation positive regulation of neuron projection development cell differentiation positive regulation of cell projection organization plasma membrane bounded cell projection organization regulation of cell projection organization nervous system development generation of neurons neuron development regulation of plasma membrane bounded cell projection organization viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction peptidyl-lysine propionylation fat cell differentiation negative regulation of cellular catabolic process negative regulation of catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of autophagy regulation of cellular catabolic process negative regulation of cellular process process utilizing autophagic mechanism negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process multicellular organism growth developmental growth growth swimming locomotion rhythmic process circadian rhythm behavioral defense response defense response response to stress somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis N-terminal peptidyl-lysine acetylation protein maturation N-terminal protein amino acid acetylation N-terminal protein amino acid modification peptidyl-lysine butyrylation peptidyl-lysine crotonylation cell cycle hemopoiesis platelet morphogenesis cell morphogenesis myeloid cell differentiation platelet formation regulation of protein modification process regulation of protein metabolic process macromolecule deacylation protein deacetylation regulation of tubulin deacetylation protein deacylation regulation of protein deacetylation tubulin deacetylation monosaccharide metabolic process negative regulation of small molecule metabolic process gluconeogenesis negative regulation of gluconeogenesis regulation of glucose metabolic process negative regulation of carbohydrate metabolic process small molecule biosynthetic process carbohydrate biosynthetic process hexose metabolic process monosaccharide biosynthetic process hexose biosynthetic process regulation of gluconeogenesis regulation of carbohydrate biosynthetic process glucose metabolic process regulation of signaling signaling regulation of signal transduction signal transduction by p53 class mediator intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of signal transduction by p53 class mediator regulation of cell communication signal transduction intracellular receptor signaling pathway response to lipid hormone-mediated signaling pathway response to hormone response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway androgen receptor signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound cellular response to hormone stimulus cellular response to organic cyclic compound regulation of androgen receptor signaling pathway steroid hormone mediated signaling pathway cellular response to lipid nuclear receptor signaling pathway intracellular steroid hormone receptor signaling pathway protein destabilization cellular response to nutrient levels response to nutrient levels negative regulation of cellular component organization regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly protein localization regulation of localization establishment of protein localization nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport positive regulation of nucleocytoplasmic transport regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport regulation of transport regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle regulation of organelle organization organelle organization regulation of mitochondrion organization mitochondrion organization response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus internal protein amino acid acetylation positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process cellular response to heat regulation of cellular response to heat regulation of cellular response to stress response to heat response to temperature stimulus cellular response to stress regulation of response to stress canonical NF-kappaB signal transduction intracellular signaling cassette megakaryocyte differentiation megakaryocyte development myeloid cell development B cell activation cell activation mononuclear cell differentiation lymphocyte differentiation lymphocyte activation leukocyte activation B cell differentiation immune system process leukocyte differentiation response to estrogen animal organ morphogenesis head development face morphogenesis head morphogenesis face development body morphogenesis positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus enzyme-linked receptor protein signaling pathway cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling tube development respiratory tube development lung development respiratory system development muscle structure development skeletal muscle organ development skeletal muscle tissue development muscle tissue development muscle organ development positive regulation of response to biotic stimulus immune response-regulating cell surface receptor signaling pathway response to biotic stimulus immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway immune response response to other organism immune response-activating cell surface receptor signaling pathway regulation of innate immune response response to external stimulus response to lectin defense response to other organism cellular response to lectin positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus innate immune response activating cell surface receptor signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway innate immune response response to external biotic stimulus positive regulation of innate immune response defense response to symbiont stimulatory C-type lectin receptor signaling pathway positive regulation of TORC1 signaling positive regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of TOR signaling positive regulation of intracellular signal transduction TORC1 signaling response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation cellular response to abiotic stimulus cellular response to UV cell surface receptor signaling pathway via STAT positive regulation of receptor signaling pathway via STAT positive regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via JAK-STAT regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT system process learning or memory nervous system process cognition intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway DNA damage response intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway foam cell differentiation macrophage derived foam cell differentiation internal peptidyl-lysine acetylation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex intracellular organelle protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle catalytic complex transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR043145	Zinc finger, ZZ-type superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR018359	Bromodomain, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036529	Coactivator CBP, KIX domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR009110	Nuclear receptor coactivator, interlocking	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000433	Zinc finger, ZZ-type	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013178	Histone acetyltransferase Rtt109/CBP	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR010303	CREB-binding protein/p300, atypical RING domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR037073	Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR014744	Nuclear receptor coactivator, CREB-bp-like, interlocking	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR038547	CBP/p300, atypical RING domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR000197	Zinc finger, TAZ-type	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR003101	Coactivator CBP, KIX domain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001487	Bromodomain	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR035898	TAZ domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR031162	CBP/p300-type histone acetyltransferase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Pharos: Q09472	Rubinstein-Taybi syndrome Stevens-Johnson syndrome transitional cell carcinoma melanoma esophageal squamous cell carcinoma urinary bladder cancer Rubinstein-Taybi syndrome due to EP300 haploinsufficiency endometrial carcinoma acute myeloid leukemia salivary gland adenoid cystic carcinoma small cell lung carcinoma obesity disorder breast carcinoma colorectal cancer Craniofacial Abnormalities Rubinstein-Taybi syndrome Stevens-Johnson syndrome transitional cell carcinoma melanoma esophageal squamous cell carcinoma urinary bladder cancer Rubinstein-Taybi syndrome due to EP300 haploinsufficiency endometrial carcinoma acute myeloid leukemia salivary gland adenoid cystic carcinoma small cell lung carcinoma obesity disorder breast carcinoma colorectal cancer Craniofacial Abnormalities squamous cell carcinoma T-cell non-Hodgkin lymphoma adenoid cystic carcinoma exocrine pancreatic carcinoma lung adenocarcinoma toxic epidermal necrolysis urinary bladder neoplasm adrenoleukodystrophy benign neoplasm of pancreas breast cancer osteogenesis imperfecta colorectal adenocarcinoma pancreatic intraductal papillary-mucinous carcinoma cutaneous melanoma rheumatoid arthritis endogenous depression hematologic disease lymphoplasmacytic lymphoma bipolar disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm prostate cancer diffuse large B-cell lymphoma endometrial cancer small cell carcinoma intellectual disability malignant glioma autism spectrum disorder breast adenocarcinoma osteoarthritis cancer ovarian cancer colorectal carcinoma pancreatic neoplasm Crohn disease psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.