Annotations: 3I2G

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3i2ga2	All beta proteins	Galactose-binding domain-like	Galactose-binding domain-like	automated matches	automated matches	(Rhodococcus sp. MB1 'Bresler 1999 ) [TaxId: 104109 ],	SCOPe (2.08)
A	d3i2ga1	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	PepX catalytic domain-like	automated matches	(Rhodococcus sp. MB1 'Bresler 1999 ) [TaxId: 104109 ],	SCOPe (2.08)
A	d3i2ga3	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Rhodococcus sp. MB1 'Bresler 1999 ) [TaxId: 104109 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	alpha/beta-Hydrolases	8037375	3000102	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	galactose-binding domain-like	8037374	3000087	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PepX_C	e3i2gA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: PepX_C	ECOD (1.6)
A	Hydrolase_4	e3i2gA2	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
A	1.10.3020.10	Mainly Alpha	Orthogonal Bundle	alpha-amino acid ester hydrolase ( Helical cap domain)	alpha-amino acid ester hydrolase ( Helical cap domain)	CATH (4.3.0)
A	2.60.120.260	Mainly Beta	Sandwich	Jelly Rolls	Galactose-binding domain-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08530	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain (PepX_C)	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	This domain contains a beta sandwich domain.	Domain
A	PF02129	X-Pro dipeptidyl-peptidase (S15 family) (Peptidase_S15)	X-Pro dipeptidyl-peptidase (S15 family)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cocaine esterase	peptidase activity catalytic activity, acting on a protein dipeptidyl-peptidase activity hydrolase activity exopeptidase activity catalytic activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity	organonitrogen compound catabolic process catabolic process organonitrogen compound metabolic process cocaine catabolic process alkaloid catabolic process alkaloid metabolic process tropane alkaloid metabolic process organic cyclic compound catabolic process cocaine metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process organic substance catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR005674	CocE/Serine esterase	Family
A	IPR000383	Xaa-Pro dipeptidyl-peptidase-like domain	Domain
A	IPR013736	Xaa-Pro dipeptidyl-peptidase, C-terminal	Domain
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.