3I01

Native structure of bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase from Moorella thermoacetica, water-bound C-cluster.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3i01a_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Carbon monoxide dehydrogenase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
B	d3i01b_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Carbon monoxide dehydrogenase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
C	d3i01c_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Carbon monoxide dehydrogenase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
D	d3i01d_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Carbon monoxide dehydrogenase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
E [auth M]	d3i01m_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Acetyl-CoA synthase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
F [auth N]	d3i01n_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Acetyl-CoA synthase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
G [auth O]	d3i01o_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Acetyl-CoA synthase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)
H [auth P]	d3i01p_	Multi-domain proteins (alpha and beta)	Prismane protein-like	Prismane protein-like	Acetyl-CoA synthase	automated matches	(Moorella thermoacetica ) [TaxId: 1525 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055590	3002294	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8055589	3001926	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033918	3001926	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8055589	3001926	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055590	3002294	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033918	3001926	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033918	3001926	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055590	3002294	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8055589	3001926	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033918	3001926	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055590	3002294	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8055589	3001926	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055630	3002294	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033920	3001926	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	CdhC linker domain-like	8055631	3002295	SCOP2B (2022-06-29)
E [auth M]	SCOP2B Superfamily	CdhC C-terminal domain-like	8055632	3002296	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	CdhC C-terminal domain-like	8055632	3002296	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055630	3002294	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	CdhC linker domain-like	8055631	3002295	SCOP2B (2022-06-29)
F [auth N]	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033920	3001926	SCOP2B (2022-06-29)
G [auth O]	SCOP2B Superfamily	CdhC linker domain-like	8055631	3002295	SCOP2B (2022-06-29)
G [auth O]	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055630	3002294	SCOP2B (2022-06-29)
G [auth O]	SCOP2B Superfamily	CdhC C-terminal domain-like	8055632	3002296	SCOP2B (2022-06-29)
G [auth O]	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033920	3001926	SCOP2B (2022-06-29)
H [auth P]	SCOP2B Superfamily	CdhC C-terminal domain-like	8055632	3002296	SCOP2B (2022-06-29)
H [auth P]	SCOP2B Superfamily	Prismane protein cluster-binding domain-like	8033920	3001926	SCOP2B (2022-06-29)
H [auth P]	SCOP2B Superfamily	Prismane protein N-terminal helical bundle-like	8055630	3002294	SCOP2B (2022-06-29)
H [auth P]	SCOP2B Superfamily	CdhC linker domain-like	8055631	3002295	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Prismane_2nd	e3i01A5	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: Prismane_2nd	ECOD (1.6)
A	Prismane_4th	e3i01A8	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
A	Prismane_3rd	e3i01A7	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_3rd	ECOD (1.6)
A	CODH	e3i01A6	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: CODH	ECOD (1.6)
B	Prismane_2nd	e3i01B5	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: Prismane_2nd	ECOD (1.6)
B	Prismane_4th	e3i01B8	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
B	Prismane_3rd	e3i01B7	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_3rd	ECOD (1.6)
B	CODH	e3i01B6	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: CODH	ECOD (1.6)
C	Prismane_2nd	e3i01C5	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: Prismane_2nd	ECOD (1.6)
C	Prismane_4th	e3i01C8	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
C	Prismane_3rd	e3i01C7	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_3rd	ECOD (1.6)
C	CODH	e3i01C6	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: CODH	ECOD (1.6)
D	Prismane_2nd	e3i01D5	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: Prismane_2nd	ECOD (1.6)
D	Prismane_4th	e3i01D8	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
D	Prismane_3rd	e3i01D7	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_3rd	ECOD (1.6)
D	CODH	e3i01D6	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: CODH	ECOD (1.6)
E [auth M]	ACS_2	e3i01M1	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: ACS_2	ECOD (1.6)
E [auth M]	CdhC	e3i01M2	A: a+b complex topology	X: first a+b domain in acetyl-CoA synthase (From Topology)	H: first a+b domain in acetyl-CoA synthase (From Topology)	T: first a+b domain in acetyl-CoA synthase	F: CdhC	ECOD (1.6)
E [auth M]	PRK09529_2nd	e3i01M3	A: a+b complex topology	X: second a+b domain in acetyl-CoA synthase (From Topology)	H: second a+b domain in acetyl-CoA synthase (From Topology)	T: second a+b domain in acetyl-CoA synthase	F: PRK09529_2nd	ECOD (1.6)
E [auth M]	Prismane_4th	e3i01M5	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
E [auth M]	PRK09529_1st	e3i01M4	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: PRK09529_1st	ECOD (1.6)
F [auth N]	ACS_2	e3i01N1	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: ACS_2	ECOD (1.6)
F [auth N]	CdhC	e3i01N2	A: a+b complex topology	X: first a+b domain in acetyl-CoA synthase (From Topology)	H: first a+b domain in acetyl-CoA synthase (From Topology)	T: first a+b domain in acetyl-CoA synthase	F: CdhC	ECOD (1.6)
F [auth N]	PRK09529_2nd	e3i01N3	A: a+b complex topology	X: second a+b domain in acetyl-CoA synthase (From Topology)	H: second a+b domain in acetyl-CoA synthase (From Topology)	T: second a+b domain in acetyl-CoA synthase	F: PRK09529_2nd	ECOD (1.6)
F [auth N]	Prismane_4th	e3i01N5	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
F [auth N]	PRK09529_1st	e3i01N4	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: PRK09529_1st	ECOD (1.6)
G [auth O]	ACS_2	e3i01O1	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: ACS_2	ECOD (1.6)
G [auth O]	CdhC	e3i01O2	A: a+b complex topology	X: first a+b domain in acetyl-CoA synthase (From Topology)	H: first a+b domain in acetyl-CoA synthase (From Topology)	T: first a+b domain in acetyl-CoA synthase	F: CdhC	ECOD (1.6)
G [auth O]	PRK09529_2nd	e3i01O3	A: a+b complex topology	X: second a+b domain in acetyl-CoA synthase (From Topology)	H: second a+b domain in acetyl-CoA synthase (From Topology)	T: second a+b domain in acetyl-CoA synthase	F: PRK09529_2nd	ECOD (1.6)
G [auth O]	Prismane_4th	e3i01O5	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
G [auth O]	PRK09529_1st	e3i01O4	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: PRK09529_1st	ECOD (1.6)
H [auth P]	ACS_2	e3i01P1	A: alpha bundles	X: Helical bundle domain in prismane-like proteins (From Topology)	H: Helical bundle domain in prismane-like proteins (From Topology)	T: Helical bundle domain in prismane-like proteins	F: ACS_2	ECOD (1.6)
H [auth P]	CdhC	e3i01P2	A: a+b complex topology	X: first a+b domain in acetyl-CoA synthase (From Topology)	H: first a+b domain in acetyl-CoA synthase (From Topology)	T: first a+b domain in acetyl-CoA synthase	F: CdhC	ECOD (1.6)
H [auth P]	PRK09529_2nd	e3i01P3	A: a+b complex topology	X: second a+b domain in acetyl-CoA synthase (From Topology)	H: second a+b domain in acetyl-CoA synthase (From Topology)	T: second a+b domain in acetyl-CoA synthase	F: PRK09529_2nd	ECOD (1.6)
H [auth P]	Prismane_4th	e3i01P5	A: a/b three-layered sandwiches	X: Rossmann-like domain in prismane-like proteins (From Topology)	H: Rossmann-like domain in prismane-like proteins (From Topology)	T: Rossmann-like domain in prismane-like proteins	F: Prismane_4th	ECOD (1.6)
H [auth P]	PRK09529_1st	e3i01P4	A: few secondary structure elements	X: Fe-binding domain in prismane-like proteins (From Topology)	H: Fe-binding domain in prismane-like proteins (From Topology)	T: Fe-binding domain in prismane-like proteins	F: PRK09529_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1270.30	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
A	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
B	1.20.1270.30	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
B	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
C	1.20.1270.30	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
C	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
D	1.20.1270.30	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
D	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
E [auth M]	1.10.8.190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
E [auth M]	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
E [auth M]	3.30.1650.10	Alpha Beta	2-Layer Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	CATH (4.3.0)
E [auth M]	3.40.970.20	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
E [auth M]	3.40.1470.10	Alpha Beta	3-Layer(aba) Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	CATH (4.3.0)
F [auth N]	1.10.8.190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
F [auth N]	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
F [auth N]	3.30.1650.10	Alpha Beta	2-Layer Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	CATH (4.3.0)
F [auth N]	3.40.970.20	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
F [auth N]	3.40.1470.10	Alpha Beta	3-Layer(aba) Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	CATH (4.3.0)
G [auth O]	1.10.8.190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
G [auth O]	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
G [auth O]	3.30.1650.10	Alpha Beta	2-Layer Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	CATH (4.3.0)
G [auth O]	3.40.970.20	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
G [auth O]	3.40.1470.10	Alpha Beta	3-Layer(aba) Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	CATH (4.3.0)
H [auth P]	1.10.8.190	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
H [auth P]	3.40.50.2030	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold		CATH (4.3.0)
H [auth P]	3.30.1650.10	Alpha Beta	2-Layer Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 3	CATH (4.3.0)
H [auth P]	3.40.970.20	Alpha Beta	3-Layer(aba) Sandwich	Ribonuclease HI	Chain A	CATH (4.3.0)
H [auth P]	3.40.1470.10	Alpha Beta	3-Layer(aba) Sandwich	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase(codh/acs), Chain M, domain 5	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF03063	Prismane/CO dehydrogenase family (Prismane)	Prismane/CO dehydrogenase family	-	Family
E [auth M], F [auth N], G [auth O], H [auth P]	PF03598	CO dehydrogenase/acetyl-CoA synthase complex beta subunit (CdhC)	CO dehydrogenase/acetyl-CoA synthase complex beta subunit	-	Domain
E [auth M], F [auth N], G [auth O], H [auth P]	PF19436	ACS/CODH beta subunit C-terminal (ACS_CODH_B_C)	ACS/CODH beta subunit C-terminal	Acetyl-CoA synthase/CO dehydrogenase (ACS/CODH) is a bifunctional enzyme that catalyses the reversible reduction of CO2 to CO (CODH activity, the beta subunit) and the synthesis or degradation of acetyl-CoA (catalysed by ACS, the alpha subunit). CODH ...	Acetyl-CoA synthase/CO dehydrogenase (ACS/CODH) is a bifunctional enzyme that catalyses the reversible reduction of CO2 to CO (CODH activity, the beta subunit) and the synthesis or degradation of acetyl-CoA (catalysed by ACS, the alpha subunit). CODH contains the B-, C-, and D-clusters. This domain represents the middle and C-terminal regions of CODH which have an alpha/beta Rossmann-like fold and are the contribute ligands to the active site C-cluster. The C-cluster generates CO from CO2 and contains one Ni atom, four Fe atoms, and five labile sulfur atoms, arranged as an asymmetrical heteronuclear [Ni-4Fe-5S] cluster [1,2,6,7].	Domain
E [auth M], F [auth N], G [auth O], H [auth P]	PF18537	Carbon monoxide dehydrogenase subunit alpha N-terminal domain (CODH_A_N)	Carbon monoxide dehydrogenase subunit alpha N-terminal domain	Acetyl-coenzyme A (CoA) synthase/carbon monoxide dehydrogenase (ACS/CODH) is a bifunctional enzyme that catalyzes the reversible reduction of CO2 to CO (CODH activity). This entry is for the N-terminal domain found in ACS/CODH subunit alpha [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit beta	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity carbon-monoxide dehydrogenase (ferredoxin) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding carbon-monoxide dehydrogenase (acceptor) activity iron-sulfur cluster binding oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor oxidoreductase activity carbon-monoxide dehydrogenase (ferredoxin) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity cation binding transition metal ion binding ion binding binding nickel cation binding metal ion binding small molecule binding carbon-monoxide dehydrogenase (acceptor) activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding	cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy organic substance metabolic process carbon fixation	-
E [auth M], F [auth N], G [auth O], H [auth P]	Carbon monoxide dehydrogenase/acetyl-CoA synthase subunit alpha	acyltransferase activity CO-methylating acetyl-CoA synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity oxidoreductase activity carbon-monoxide dehydrogenase (acceptor) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding acyltransferase activity CO-methylating acetyl-CoA synthase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity oxidoreductase activity carbon-monoxide dehydrogenase (acceptor) activity oxidoreductase activity, acting on the aldehyde or oxo group of donors iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process acetyl-CoA metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process carbohydrate derivative metabolic process acetyl-CoA metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process organic substance metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process amide metabolic process thioester metabolic process phosphorus metabolic process nucleoside phosphate metabolic process organonitrogen compound metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organic cyclic compound metabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process carbon fixation	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR010047	Ni-containing CO dehydrogenase	Family
A, B, C, D	IPR016099	Prismane-like, alpha/beta-sandwich	Homologous Superfamily
A, B, C, D	IPR004137	Hydroxylamine reductase/Ni-containing CO dehydrogenase	Family
A, B, C, D	IPR016101	CO dehydrogenase, alpha-bundle	Homologous Superfamily
A, B, C, D	IPR011254	Prismane-like superfamily	Homologous Superfamily
E [auth M], F [auth N], G [auth O], H [auth P]	IPR041350	Carbon monoxide dehydrogenase subunit alpha ,N-terminal	Domain
E [auth M], F [auth N], G [auth O], H [auth P]	IPR016099	Prismane-like, alpha/beta-sandwich	Homologous Superfamily
E [auth M], F [auth N], G [auth O], H [auth P]	IPR004461	CO dehydrogenase/acetyl-CoA synthase complex beta subunit	Family
E [auth M], F [auth N], G [auth O], H [auth P]	IPR045822	CO dehydrogenase/acetyl-CoA synthase complex beta subunit , C-terminal	Domain
E [auth M], F [auth N], G [auth O], H [auth P]	IPR038571	Bifunctional carbon monoxide dehydrogenase/acetyl-coa synthase, domain 3 superfamily	Homologous Superfamily
E [auth M], F [auth N], G [auth O], H [auth P]	IPR011254	Prismane-like superfamily	Homologous Superfamily