3HRV

Crystal structure of TcpA, a Type IV pilin from Vibrio cholerae El Tor biotype

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3hrva1	Alpha and beta proteins (a+b)	Pili subunits	Pili subunits	TcpA-like pilin	Toxin-coregulated pilus subunit TcpA	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)
A	d3hrva2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)
B	d3hrvb_	Alpha and beta proteins (a+b)	Pili subunits	Pili subunits	TcpA-like pilin	Toxin-coregulated pilus subunit TcpA	(Vibrio cholerae ) [TaxId: 666 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	TcpA-like pilin	8078658	4000607	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Pili subunits	8078659	3000097	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Pili subunits	8078659	3000097	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05946	e3hrvA1	A: a+b two layers	X: Pili subunits (From Topology)	H: Pili subunits (From Topology)	T: Pili subunits	F: PF05946	ECOD (1.6)
B	PF05946	e3hrvB1	A: a+b two layers	X: Pili subunits (From Topology)	H: Pili subunits (From Topology)	T: Pili subunits	F: PF05946	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1690.10	Alpha Beta	2-Layer Sandwich	TcpA-like pilin	TcpA-like pilin	CATH (4.3.0)
B	3.30.1690.10	Alpha Beta	2-Layer Sandwich	TcpA-like pilin	TcpA-like pilin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05946	Toxin-coregulated pilus subunit TcpA (TcpA)	Toxin-coregulated pilus subunit TcpA	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Toxin coregulated pilin	-	protein localization protein transport across the cell outer membrane establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion by the type II secretion system protein secretion establishment of localization protein localization to extracellular region transmembrane transport protein localization protein transport across the cell outer membrane establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion by the type II secretion system protein secretion establishment of localization protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization cellular process	membrane cellular anatomical entity protein-containing complex type II protein secretion system complex pilus cell projection extracellular organelle extracellular region organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012902	Prokaryotic N-terminal methylation site	PTM
A, B	IPR010271	Toxin-coregulated pilus subunit TcpA	Family
A, B	IPR045584	Pilin-like	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.