3HR4

Human iNOS Reductase and Calmodulin Complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3hr4b_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3hr4d_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d3hr4f_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d3hr4h_	All alpha proteins	EF Hand-like	EF-hand	Calmodulin-like	Calmodulin	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Flavoproteins	8077825	3001217	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Flavoproteins	8077825	3001217	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Flavoproteins	8077825	3001217	SCOP2B (2022-06-29)
G	SCOP2 Family	Cytochrome p450 reductase N-terminal domain-like	8077824	4003670	SCOP2 (2022-06-29)
G	SCOP2 Superfamily	Flavoproteins	8077825	3001217	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	EF-hand	8033438	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00258	e3hr4A1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: PF00258	ECOD (1.6)
C	PF00258	e3hr4C2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: PF00258	ECOD (1.6)
E	PF00258	e3hr4E2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: PF00258	ECOD (1.6)
G	PF00258	e3hr4G2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: PF00258	ECOD (1.6)
B	PF00036	e3hr4B1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
B	PF13499	e3hr4B2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
D	PF00036	e3hr4D1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
D	PF13499	e3hr4D2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
F	PF00036	e3hr4F1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
F	PF13499	e3hr4F2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)
H	PF00036	e3hr4H1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF00036	ECOD (1.6)
H	PF13499	e3hr4H2	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF13499	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.250.410	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	3.40.50.360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavodoxin domain	CATH (4.3.0)
C	6.10.250.410	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	3.40.50.360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavodoxin domain	CATH (4.3.0)
E	3.40.50.360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavodoxin domain	CATH (4.3.0)
G	6.10.250.410	Special	Helix non-globular	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
G	3.40.50.360	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Flavodoxin domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E, G	PF00258	Flavodoxin (Flavodoxin_1)	Flavodoxin	-	Domain
B, D, F, H	PF13499	EF-hand domain pair (EF-hand_7)	EF-hand domain pair	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E, G	Nitric oxide synthase, inducible	binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding flavin adenine dinucleotide binding cation binding organic acid binding binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding flavin adenine dinucleotide binding cation binding organic acid binding amino acid binding carboxylic acid binding arginine binding oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen nitric-oxide synthase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity protein binding calmodulin binding metal ion binding tetrahydrobiopterin binding purine nucleotide binding adenyl nucleotide binding NADP binding identical protein binding protein homodimerization activity protein dimerization activity tetrapyrrole binding heme binding	prostaglandin transport transport signaling cell communication localization secretion by cell monocarboxylic acid transport fatty acid transport icosanoid transport signal release prostaglandin secretion icosanoid secretion regulation of biological process organic anion transport prostaglandin transport transport signaling cell communication localization secretion by cell monocarboxylic acid transport fatty acid transport icosanoid transport signal release prostaglandin secretion icosanoid secretion regulation of biological process organic anion transport carboxylic acid transport secretion organic substance transport biological regulation cell-cell signaling export from cell lipid localization lipid transport establishment of localization organic acid transport lipid export from cell macromolecule localization cellular process catabolic process oxoacid metabolic process glutamine family amino acid catabolic process amino acid metabolic process arginine catabolic process organic acid metabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process arginine metabolic process organic substance metabolic process carboxylic acid catabolic process small molecule metabolic process amino acid catabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process cellular metabolic process carboxylic acid metabolic process L-amino acid catabolic process primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process alpha-amino acid catabolic process proteinogenic amino acid catabolic process metabolic process small molecule catabolic process organic substance catabolic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus peptidyl-cysteine modification peptidyl-cysteine S-nitrosylation macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process protein nitrosylation multicellular organismal process regulation of cellular process positive regulation of interleukin-8 production cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production organic substance biosynthetic process regulation of cytokine production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of cellular metabolic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process regulation of interleukin-8 production protein localization regulation of localization establishment of protein localization nitrogen compound transport cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion hormone secretion protein localization to extracellular region peptide secretion regulation of secretion by cell amide transport regulation of signaling regulation of transport regulation of peptide transport regulation of establishment of protein localization regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion hormone transport regulation of cell communication insulin secretion cell redox homeostasis cellular homeostasis homeostatic process response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus defense response to Gram-negative bacterium cellular response to stimulus cellular response to chemical stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus negative regulation of biological process macromolecule catabolic process negative regulation of protein catabolic process regulation of primary metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of catabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process regulation of protein catabolic process response to organic substance response to hormone response to endogenous stimulus rhythmic process circadian rhythm nitric oxide mediated signal transduction intracellular signal transduction intracellular signaling cassette signal transduction superoxide metabolic process reactive oxygen species metabolic process interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to lipid cellular response to organic substance response to molecule of bacterial origin regulation of immune effector process positive regulation of leukocyte mediated immunity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity immune effector process regulation of leukocyte mediated immunity positive regulation of leukocyte mediated cytotoxicity immune system process leukocyte mediated immunity regulation of immune system process regulation of cell killing positive regulation of immune effector process positive regulation of cell killing positive regulation of immune system process cell killing response to type II interferon response to cytokine cellular response to type II interferon innate immune response cellular response to cytokine stimulus immune response defense response to symbiont innate immune response in mucosa mucosal immune response organ or tissue specific immune response regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response inflammatory response positive regulation of programmed cell death positive regulation of killing of cells of another organism regulation of killing of cells of another organism disruption of cell in another organism regulation of programmed cell death cell death disruption of anatomical structure in another organism modulation of process of another organism programmed cell death killing of cells of another organism cell population proliferation regulation of cell population proliferation negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular respiration energy derivation by oxidation of organic compounds regulation of generation of precursor metabolites and energy generation of precursor metabolites and energy regulation of cellular respiration system process circulatory system process regulation of blood pressure negative regulation of blood pressure blood circulation nitric oxide metabolic process nitric oxide biosynthetic process reactive nitrogen species metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle peroxisome microbody intracellular membrane-bounded organelle perinuclear region of cytoplasm peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular organelle organelle peroxisome microbody intracellular membrane-bounded organelle perinuclear region of cytoplasm peroxisomal matrix membrane-enclosed lumen intracellular organelle lumen organelle lumen microbody lumen cell cortex cortical cytoskeleton cell periphery cytoskeleton intracellular non-membrane-bounded organelle non-membrane-bounded organelle plasma membrane membrane nucleus nucleoplasm nuclear lumen
B, D, F, H	Calmodulin	cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity molecular function inhibitor activity channel regulator activity cytoskeletal protein binding titin binding protein binding binding enzyme regulator activity protein phosphatase activator activity enzyme activator activity phosphatase activator activity molecular function activator activity phosphatase regulator activity molecular function regulator activity protein phosphatase regulator activity molecular function inhibitor activity channel regulator activity transporter inhibitor activity calcium channel inhibitor activity ion channel inhibitor activity ion channel regulator activity calcium channel regulator activity transporter regulator activity channel inhibitor activity cyclase regulator activity cyclase activator activity adenylate cyclase regulator activity adenylate cyclase activator activity protein serine/threonine kinase activator activity kinase activator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity cation binding ion binding calcium ion binding metal ion binding small molecule binding transmembrane transporter binding kinase binding enzyme binding protein kinase binding calcium-dependent protein binding	organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation organelle localization by membrane tethering localization organelle localization cellular process membrane docking heart process multicellular organismal process system process regulation of biological process regulation of heart contraction regulation of system process biological regulation circulatory system process regulation of blood circulation regulation of multicellular organismal process regulation of biological quality heart contraction blood circulation regulation of heart rate positive regulation of phosphoprotein phosphatase activity protein dephosphorylation regulation of cellular process regulation of phosphatase activity regulation of catalytic activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of phosphatase activity positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation cellular metabolic process dephosphorylation regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function regulation of hydrolase activity macromolecule modification regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process positive regulation of cellular metabolic process regulation of phosphoprotein phosphatase activity positive regulation of molecular function positive regulation of protein modification process organic substance metabolic process protein metabolic process positive regulation of cellular process organonitrogen compound metabolic process regulation of protein dephosphorylation positive regulation of catalytic activity positive regulation of protein dephosphorylation regulation of macromolecule metabolic process positive regulation of hydrolase activity regulation of calcium ion transmembrane transporter activity regulation of calcium ion transport regulation of localization negative regulation of ion transmembrane transporter activity negative regulation of calcium ion transmembrane transporter activity intracellular calcium ion homeostasis negative regulation of biological process negative regulation of ryanodine-sensitive calcium-release channel activity negative regulation of transport calcium ion transport negative regulation of cation transmembrane transport monoatomic cation homeostasis monoatomic cation transport intracellular monoatomic ion homeostasis regulation of release of sequestered calcium ion into cytosol regulation of monoatomic ion transport inorganic ion transmembrane transport establishment of localization regulation of cation channel activity inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol regulation of transmembrane transport chemical homeostasis negative regulation of calcium ion transmembrane transport cellular localization inorganic ion homeostasis transport negative regulation of cation channel activity homeostatic process monoatomic ion transmembrane transport negative regulation of monoatomic ion transport regulation of transmembrane transporter activity calcium ion homeostasis regulation of monoatomic ion transmembrane transport negative regulation of sequestering of calcium ion metal ion transport negative regulation of transmembrane transport regulation of transporter activity maintenance of location in cell regulation of calcium ion transmembrane transport monoatomic cation transmembrane transport positive regulation of sequestering of calcium ion negative regulation of monoatomic ion transmembrane transport negative regulation of release of sequestered calcium ion into cytosol intracellular monoatomic cation homeostasis negative regulation of cellular process monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis regulation of metal ion transport regulation of sequestering of calcium ion regulation of monoatomic ion transmembrane transporter activity calcium ion transmembrane import into cytosol regulation of transport sequestering of calcium ion negative regulation of transporter activity negative regulation of molecular function negative regulation of calcium ion transport cellular homeostasis regulation of ryanodine-sensitive calcium-release channel activity regulation of monoatomic cation transmembrane transport calcium ion transmembrane transport response to stimulus response to metal ion response to chemical response to calcium ion response to inorganic substance sarcoplasmic reticulum calcium ion transport release of sequestered calcium ion into cytosol by sarcoplasmic reticulum release of sequestered calcium ion into cytosol by endoplasmic reticulum regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum negative regulation of voltage-gated calcium channel activity regulation of voltage-gated calcium channel activity negative regulation of high voltage-gated calcium channel activity regulation of high voltage-gated calcium channel activity cellular component disassembly catabolic process macroautophagy protein-containing complex organization autophagy protein-containing complex disassembly cellular catabolic process cellular component organization autophagosome maturation autophagosome membrane docking cellular component organization or biogenesis process utilizing autophagic mechanism cellular response to stimulus response to interferon-beta response to organic substance response to cytokine cellular response to interferon-beta cellular response to chemical stimulus cellular response to cytokine stimulus cellular response to organic substance regulation of cytokinesis regulation of cell cycle process cytokinesis regulation of cell division cell division cell cycle regulation of cell cycle cell cycle process positive regulation of cyclic-nucleotide phosphodiesterase activity regulation of cyclic-nucleotide phosphodiesterase activity cardiac muscle contraction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cardiac muscle contraction muscle contraction regulation of striated muscle contraction calcium-mediated signaling regulation of muscle contraction signaling regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion striated muscle contraction regulation of cardiac muscle contraction by calcium ion signaling muscle system process regulation of muscle system process mitochondrion-endoplasmic reticulum membrane tethering positive regulation of phosphorylation regulation of transferase activity positive regulation of protein serine/threonine kinase activity positive regulation of protein phosphorylation protein phosphorylation phosphorylation positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of protein phosphorylation positive regulation of protein kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation cell cycle G2/M phase transition mitotic cell cycle process G2/M transition of mitotic cell cycle cell cycle phase transition mitotic cell cycle mitotic cell cycle phase transition regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process negative regulation of protein modification process peptidyl-amino acid modification peptidyl-threonine modification negative regulation of protein metabolic process negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of protein phosphorylation negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphorus metabolic process negative regulation of phosphorylation peptidyl-threonine phosphorylation positive regulation of peptidyl-threonine phosphorylation cell communication by electrical coupling involved in cardiac conduction cell communication by electrical coupling regulation of cell communication by electrical coupling involved in cardiac conduction cardiac conduction regulation of cell communication cell communication involved in cardiac conduction regulation of cell communication by electrical coupling export across plasma membrane negative regulation of calcium ion export across plasma membrane regulation of calcium ion export across plasma membrane calcium ion export across plasma membrane export from cell biological process involved in interspecies interaction between organisms response to type II interferon cellular response to type II interferon response to biotic stimulus response to stress innate immune response response to external biotic stimulus immune response response to other organism defense response defense response to symbiont response to external stimulus immune system process defense response to other organism positive regulation of cation transmembrane transport positive regulation of calcium ion transport positive regulation of monoatomic ion transport positive regulation of monoatomic ion transmembrane transport positive regulation of cation channel activity positive regulation of calcium ion transmembrane transporter activity positive regulation of calcium ion transmembrane transport positive regulation of transmembrane transport positive regulation of release of sequestered calcium ion into cytosol positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of transport positive regulation of transporter activity positive regulation of ion transmembrane transporter activity developmental process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development anatomical structure development neural nucleus development system development positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT regulation of signal transduction positive regulation of receptor signaling pathway via JAK-STAT positive regulation of response to stimulus regulation of receptor signaling pathway via JAK-STAT regulation of signaling cell surface receptor signaling pathway regulation of response to stimulus regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT positive regulation of signaling regulation of intracellular signal transduction regulation of calcium-mediated signaling regulation of action potential regulation of cardiac muscle cell action potential action potential cardiac muscle cell action potential regulation of membrane potential G protein-coupled receptor signaling pathway protein autophosphorylation regulation of protein autophosphorylation positive regulation of protein autophosphorylation detection of stimulus detection of chemical stimulus detection of calcium ion	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle cell projection intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle cytoplasm cytosol membrane-bounded organelle cell projection sperm midpiece cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection protein-containing complex transmembrane transporter complex membrane membrane protein complex cation channel complex transporter complex calcium channel complex monoatomic ion channel complex sarcomere contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex myelin sheath vesicle centrosome microtubule organizing center cell periphery plasma membrane catalytic complex nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen voltage-gated potassium channel complex plasma membrane protein complex potassium channel complex extracellular region polymeric cytoskeletal fiber spindle microtubule microtubule

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E, G	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase	Domain
A, C, E, G	IPR001433	Oxidoreductase FAD/NAD(P)-binding	Domain
A, C, E, G	IPR001094	Flavodoxin-like	Domain
A, C, E, G	IPR004030	Nitric oxide synthase, N-terminal	Domain
A, C, E, G	IPR023173	NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily	Homologous Superfamily
A, C, E, G	IPR008254	Flavodoxin/nitric oxide synthase	Domain
A, C, E, G	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Homologous Superfamily
A, C, E, G	IPR017927	FAD-binding domain, ferredoxin reductase-type	Domain
A, C, E, G	IPR036119	Nitric oxide synthase, N-terminal domain superfamily	Homologous Superfamily
A, C, E, G	IPR044944	Nitric oxide synthase, domain 3 superfamily	Homologous Superfamily
A, C, E, G	IPR044943	Nitric oxide synthase, domain 1 superfamily	Homologous Superfamily
A, C, E, G	IPR003097	Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding	Domain
A, C, E, G	IPR017938	Riboflavin synthase-like beta-barrel	Homologous Superfamily
A, C, E, G	IPR044940	Nitric oxide synthase, domain 2 superfamily	Homologous Superfamily
A, C, E, G	IPR029039	Flavoprotein-like superfamily	Homologous Superfamily
A, C, E, G	IPR012144	Nitric-oxide synthase, eukaryote	Family
B, D, F, H	IPR002048	EF-hand domain	Domain
B, D, F, H	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
B, D, F, H	IPR011992	EF-hand domain pair	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, E, G	Pharos: P35228	psoriasis hypertensive disorder Marfan syndrome sclerosing cholangitis silicosis Stevens-Johnson syndrome duodenal ulcer Turner syndrome status epilepticus malaria psoriatic arthritis Takayasu arteritis cholangiocarcinoma asbestosis asthma psoriasis hypertensive disorder Marfan syndrome sclerosing cholangitis silicosis Stevens-Johnson syndrome duodenal ulcer Turner syndrome status epilepticus malaria psoriatic arthritis Takayasu arteritis cholangiocarcinoma asbestosis asthma visual epilepsy liver disease congestive heart failure malignant colon neoplasm Diabetes Mellitus, Experimental primary sclerosing cholangitis breast carcinoma substance withdrawal syndrome myocardial infarction essential hypertension toxic shock syndrome intestinal schistosomiasis cholestasis focal segmental glomerulosclerosis aspiration pneumonia perinatal necrotizing enterocolitis brain ischemia bronchial disease retinal disease secondary Parkinson disease intestinal disease intrahepatic cholangiocarcinoma ureteral obstruction gastric ulcer kidney disease colitis atherosclerosis brain edema subarachnoid hemorrhage manganese poisoning esophageal cancer myocardial stunning type 2 diabetes mellitus Crohn disease heart failure lung carcinoma brain hypoxia - ischemia pulmonary emphysema acute kidney failure pustulosis palmaris et plantaris extrahepatic cholestasis ulcerative colitis neoplasm of esophagus chronic obstructive pulmonary disease benign colon neoplasm sinusitis primary biliary cholangitis bowel dysfunction maturity-onset diabetes of the young essential hypertension, genetic cerebrovascular disorder arteriosclerosis disorder aspiration pneumonitis autism lung benign neoplasm cystic fibrosis bile duct cancer depressive disorder primary ovarian failure breast cancer burn ankylosing spondylitis inborn mitochondrial metabolism disorder toxic epidermal necrolysis urinary tract infection necrotizing enterocolitis ischemia reperfusion injury colonic neoplasm
B, D, F, H	Pharos: P0DP23	long QT syndrome catecholaminergic polymorphic ventricular tachycardia Alzheimer disease long QT syndrome 14 cocaine abuse Weight Gain cannabis dependence cocaine dependence phencyclidine abuse catecholaminergic polymorphic ventricular tachycardia 4 rheumatoid arthritis subependymal giant cell astrocytoma glioblastoma large cell medulloblastoma lung adenocarcinoma long QT syndrome catecholaminergic polymorphic ventricular tachycardia Alzheimer disease long QT syndrome 14 cocaine abuse Weight Gain cannabis dependence cocaine dependence phencyclidine abuse catecholaminergic polymorphic ventricular tachycardia 4 rheumatoid arthritis subependymal giant cell astrocytoma glioblastoma large cell medulloblastoma lung adenocarcinoma malignant colon neoplasm malignant pancreatic neoplasm myopathy astrocytic tumor osteosarcoma pituitary cancer primitive neuroectodermal tumor Crohn disease schizophrenia familial long QT syndrome lung cancer malignant ependymoma nasopharyngeal carcinoma atypical teratoid rhabdoid tumor ovarian cancer Pick disease catecholaminergic polymorphic ventricular tachycardia 2 plasma cell myeloma psoriasis exocrine pancreatic carcinoma sinusitis ulcerative colitis hepatocellular carcinoma lymphoplasmacytic lymphoma malignant glioma medulloblastoma amyotrophic lateral sclerosis oligodendroglioma breast cancer pilocytic astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.