3HHD
Structure of the Human Fatty Acid Synthase KS-MAT Didomain as a Framework for Inhibitor Design.
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2 Family | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 8055825 | 4001289 | SCOP2 (2022-06-29) |
A | SCOP2 Family | Thiolase-related | 8055821 | 4000245 | SCOP2 (2022-06-29) |
A | SCOP2 Family | KASAT domain-like | 8045093 | 4004293 | SCOP2 (2022-06-29) |
A | SCOP2 Family | FabD-like | 8055823 | 4003614 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 8055826 | 3001224 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | Thiolase-like | 8055822 | 3000122 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2 (2022-06-29) |
A | SCOP2 Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2 (2022-06-29) |
C | SCOP2B Superfamily | Thiolase-like | 8055822 | 3000122 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2B (2022-06-29) |
C | SCOP2B Superfamily | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 8055826 | 3001224 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Thiolase-like | 8055822 | 3000122 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 8055826 | 3001224 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2B (2022-06-29) |
D | SCOP2B Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Thiolase-like | 8055822 | 3000122 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | KASAT domain-like | 8055820 | 3002319 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | FabD/lysophospholipase-like | 8055824 | 3001121 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Probable ACP-binding domain of malonyl-CoA ACP transacylase | 8055826 | 3001224 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00698 | e3hhdA2 | A: a+b two layers | X: Alpha-beta plaits | H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology) | T: Probable ACP-binding domain of malonyl-CoA ACP transacylase | F: PF00698 | ECOD (1.6) |
A | PF16197 | e3hhdA5 | A: a+b two layers | X: KS-MAT linker domain in fatty acid synthase (From Topology) | H: KS-MAT linker domain in fatty acid synthase (From Topology) | T: KS-MAT linker domain in fatty acid synthase | F: PF16197 | ECOD (1.6) |
A | PF00698 | e3hhdA1 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: FabD/lysophospholipase-like | F: PF00698 | ECOD (1.6) |
A | PF00109 | e3hhdA4 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF00109 | ECOD (1.6) |
A | PF02801,PF16197 | e3hhdA3 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF02801,PF16197 | ECOD (1.6) |
C | PF00698 | e3hhdC8 | A: a+b two layers | X: Alpha-beta plaits | H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology) | T: Probable ACP-binding domain of malonyl-CoA ACP transacylase | F: PF00698 | ECOD (1.6) |
C | PF16197 | e3hhdC5 | A: a+b two layers | X: KS-MAT linker domain in fatty acid synthase (From Topology) | H: KS-MAT linker domain in fatty acid synthase (From Topology) | T: KS-MAT linker domain in fatty acid synthase | F: PF16197 | ECOD (1.6) |
C | PF00698 | e3hhdC6 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: FabD/lysophospholipase-like | F: PF00698 | ECOD (1.6) |
C | PF00109 | e3hhdC7 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF00109 | ECOD (1.6) |
C | PF02801,PF16197 | e3hhdC9 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF02801,PF16197 | ECOD (1.6) |
D | PF00698 | e3hhdD8 | A: a+b two layers | X: Alpha-beta plaits | H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology) | T: Probable ACP-binding domain of malonyl-CoA ACP transacylase | F: PF00698 | ECOD (1.6) |
D | PF16197 | e3hhdD5 | A: a+b two layers | X: KS-MAT linker domain in fatty acid synthase (From Topology) | H: KS-MAT linker domain in fatty acid synthase (From Topology) | T: KS-MAT linker domain in fatty acid synthase | F: PF16197 | ECOD (1.6) |
D | PF00698 | e3hhdD6 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: FabD/lysophospholipase-like | F: PF00698 | ECOD (1.6) |
D | PF00109 | e3hhdD7 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF00109 | ECOD (1.6) |
D | PF02801,PF16197 | e3hhdD9 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF02801,PF16197 | ECOD (1.6) |
B | PF00698 | e3hhdB8 | A: a+b two layers | X: Alpha-beta plaits | H: Probable ACP-binding domain of malonyl-CoA ACP transacylase (From Topology) | T: Probable ACP-binding domain of malonyl-CoA ACP transacylase | F: PF00698 | ECOD (1.6) |
B | PF16197 | e3hhdB5 | A: a+b two layers | X: KS-MAT linker domain in fatty acid synthase (From Topology) | H: KS-MAT linker domain in fatty acid synthase (From Topology) | T: KS-MAT linker domain in fatty acid synthase | F: PF16197 | ECOD (1.6) |
B | PF00698 | e3hhdB6 | A: a/b three-layered sandwiches | X: Flavodoxin-like | H: Class I glutamine amidotransferase-like | T: FabD/lysophospholipase-like | F: PF00698 | ECOD (1.6) |
B | PF00109 | e3hhdB7 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF00109 | ECOD (1.6) |
B | PF02801,PF16197 | e3hhdB9 | A: a/b three-layered sandwiches | X: Thiolase-like (From Topology) | H: Thiolase-like (From Topology) | T: Thiolase-like | F: PF02801,PF16197 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02801 | Beta-ketoacyl synthase, C-terminal domain (Ketoacyl-synt_C) | Beta-ketoacyl synthase, C-terminal domain | The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. | Domain | |
PF00109 | Beta-ketoacyl synthase, N-terminal domain (ketoacyl-synt) | Beta-ketoacyl synthase, N-terminal domain | The structure of beta-ketoacyl synthase is similar to that of the thiolase family (Pfam:PF00108) and also chalcone synthase. The active site of beta-ketoacyl synthase is located between the N and C-terminal domains. The N-terminal domain contains m ... | Domain | |
PF16197 | Ketoacyl-synthetase C-terminal extension (KAsynt_C_assoc) | Ketoacyl-synthetase C-terminal extension | - | Family | |
PF00698 | Acyl transferase domain (Acyl_transf_1) | Acyl transferase domain | - | Domain |