3HHC

Interferon-lambda is functionally an interferon but structurally related to the IL-10 family

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF15177	e3hhcA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: PF15177	ECOD (1.6)
B	PF15177	e3hhcB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: PF15177	ECOD (1.6)
C	PF15177	e3hhcC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: PF15177	ECOD (1.6)
D	PF15177	e3hhcD1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: PF15177	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.1250.60	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
B	1.20.1250.60	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
C	1.20.1250.60	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF15177	Interleukin-28A (IL28A)	Interleukin-28A	The protein family, Interleukin-28A, plays an important role in modulating the immune system. This protein family is induced by viral infection and interacts with a class II receptor [1]. This family of proteins is found in eukaryotes. Proteins in th ...	The protein family, Interleukin-28A, plays an important role in modulating the immune system. This protein family is induced by viral infection and interacts with a class II receptor [1]. This family of proteins is found in eukaryotes. Proteins in this family are typically between 145 and 195 amino acids in length.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Interleukin-28B	protein binding binding signaling receptor binding molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process negative regulation of viral genome replication negative regulation of biological process regulation of biological process response to stimulus immune response biological regulation positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process negative regulation of viral genome replication negative regulation of biological process viral life cycle negative regulation of viral process regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication cellular response to stimulus response to organic substance regulation of cellular process biological process involved in interspecies interaction between organisms signaling response to cytokine response to type III interferon cytokine-mediated signaling pathway response to biotic stimulus cell communication interferon-mediated signaling pathway response to stress innate immune response cellular response to cytokine stimulus cellular response to organic substance signal transduction response to external biotic stimulus cell surface receptor signaling pathway response to other organism defense response type III interferon-mediated signaling pathway defense response to symbiont response to external stimulus cellular response to chemical stimulus response to chemical defense response to other organism cellular process cellular response to type III interferon cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT defense response to virus response to virus cellular response to virus	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR038326	Interferon lambda superfamily	Homologous Superfamily
A, B, C, D	IPR029177	Interferon lambda	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q8IZI9	hepatitis C virus infection asthma food allergy head and neck squamous cell carcinoma isolated congenital hepatic fibrosis cirrhosis of liver ovarian mucinous adenocarcinoma atopic eczema brain injury dermatitis, atopic hepatocellular carcinoma schizophrenia hepatitis major depressive disorder

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.