3HH7

Structural and Functional Characterization of a Novel Homodimeric Three-finger Neurotoxin from the Venom of Ophiophagus hannah (King Cobra)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3hh7a_	Small proteins	Snake toxin-like	Snake toxin-like	automated matches	automated matches	(Ophiophagus hannah ) [TaxId: 8665 ],	SCOPe (2.08)
B	d3hh7b_	Small proteins	Snake toxin-like	Snake toxin-like	automated matches	automated matches	(Ophiophagus hannah ) [TaxId: 8665 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF21947	e3hh7A1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF21947	ECOD (1.6)
B	PF21947	e3hh7B1	A: few secondary structure elements	X: Snake toxin-like (From Topology)	H: Snake toxin-like (From Topology)	T: Snake toxin-like	F: PF21947	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)
B	2.10.60.10	Mainly Beta	Ribbon	CD59	CD59	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Muscarinic toxin-like protein 3 homolog	channel regulator activity ion channel regulator activity molecular function regulator activity transporter regulator activity neurotransmitter receptor regulator activity acetylcholine receptor regulator activity molecular function inhibitor activity acetylcholine receptor inhibitor activity signaling receptor inhibitor activity signaling receptor regulator activity toxin activity	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR018354	Snake toxin, conserved site	Conserved Site
A, B	IPR045860	Snake toxin-like superfamily	Homologous Superfamily
A, B	IPR003571	Snake three-finger toxin	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.