3HEQ
Human prion protein variant D178N with M129
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF00377 | e3heqA1 | A: a+b two layers | X: Prion-like (From Topology) | H: Prion-like (From Topology) | T: Prion-like | F: PF00377 | ECOD (1.6) |
B | PF00377 | e3heqB1 | A: a+b two layers | X: Prion-like (From Topology) | H: Prion-like (From Topology) | T: Prion-like | F: PF00377 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.790.10 | Mainly Alpha | Orthogonal Bundle | Major Prion Protein | Prion/Doppel protein, beta-ribbon domain | CATH (4.3.0) |
B | 1.10.790.10 | Mainly Alpha | Orthogonal Bundle | Major Prion Protein | Prion/Doppel protein, beta-ribbon domain | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00377 | Prion/Doppel alpha-helical domain (Prion) | Prion/Doppel alpha-helical domain | The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR022416 | Prion/Doppel protein, beta-ribbon domain | Domain | |
IPR025860 | Major prion protein N-terminal domain | Domain | |
IPR036924 | Prion/Doppel beta-ribbon domain superfamily | Homologous Superfamily | |
IPR000817 | Prion protein | Family |