Annotations: 3HAH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	FCH	e3hahB1	A: alpha duplicates or obligate multimers	X: BAR/IMD domain-like	H: BAR/IMD domain-like (From Topology)	T: BAR/IMD domain-like	F: FCH	ECOD (1.6)
A	FCH	e3hahA1	A: alpha duplicates or obligate multimers	X: BAR/IMD domain-like	H: BAR/IMD domain-like (From Topology)	T: BAR/IMD domain-like	F: FCH	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.1270.60	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)
A	1.20.1270.60	Mainly Alpha	Up-down Bundle	Substrate Binding Domain Of Dnak	Chain:A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00611	Fes/CIP4, and EFC/F-BAR homology domain (FCH)	Fes/CIP4, and EFC/F-BAR homology domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	human PACSIN1 F-BAR	cytoskeletal protein binding protein binding binding phospholipid binding lipid binding identical protein binding	synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis synaptic vesicle endocytosis import into cell cellular localization transport synaptic vesicle cycle establishment of localization vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle recycling localization establishment of localization in cell cellular process endocytosis regulation of localization regulation of biological process regulation of cellular process regulation of cellular component organization regulation of transport biological regulation regulation of vesicle-mediated transport cellular component organization cellular component organization or biogenesis regulation of endocytosis protein localization protein localization to cell periphery protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane multicellular organismal process cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development generation of neurons anatomical structure morphogenesis neuron development plasma membrane tubulation membrane organization plasma membrane organization endomembrane system organization organelle organization cytoskeleton organization negative regulation of cellular component organization negative regulation of biological process negative regulation of transport negative regulation of endocytosis negative regulation of cellular process regulation of neuron projection development positive regulation of cellular component organization regulation of developmental process positive regulation of biological process positive regulation of developmental process dendrite development positive regulation of neuron projection development positive regulation of cell projection organization positive regulation of cellular process regulation of cell projection organization positive regulation of dendrite development regulation of dendrite development regulation of plasma membrane bounded cell projection organization actin cytoskeleton organization actin filament organization actin filament-based process supramolecular fiber organization	ruffle cell leading edge plasma membrane membrane leading edge membrane cellular anatomical entity plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm ruffle cell leading edge plasma membrane membrane leading edge membrane cellular anatomical entity plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle membrane vesicle membrane cytoplasmic vesicle organelle vesicle organelle membrane COPI-coated vesicle coated vesicle Golgi-associated vesicle photoreceptor ribbon synapse synapse cell junction ribbon synapse presynapse presynaptic endocytic zone endosome endomembrane system perinuclear region of cytoplasm axon neuron projection axon terminus distal axon neuron projection terminus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR035743	PACSIN1/PACSIN2, SH3 domain	Domain
A, B	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A, B	IPR027267	AH/BAR domain superfamily	Homologous Superfamily
A, B	IPR037454	PACSIN1, F-BAR	Domain
A, B	IPR031160	F-BAR domain	Domain
A, B	IPR001452	SH3 domain	Domain
A, B	IPR001060	FCH domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BY11	subependymal giant cell astrocytoma astrocytic tumor bipolar disorder glioblastoma malignant ependymoma metabolic syndrome X pancreatic intraductal papillary-mucinous neoplasm pituitary cancer atypical teratoid rhabdoid tumor breast cancer heart disease malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor subependymal giant cell astrocytoma astrocytic tumor bipolar disorder glioblastoma malignant ependymoma metabolic syndrome X pancreatic intraductal papillary-mucinous neoplasm pituitary cancer atypical teratoid rhabdoid tumor breast cancer heart disease malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia primitive neuroectodermal tumor B-cell chronic lymphocytic leukemia gastroesophageal reflux disease large cell medulloblastoma medulloblastoma osteosarcoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.