3HA5

Crystal structure of HMA (MMAA4) from mycobacterium tuberculosis complexed with sinefungin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3ha5a_	Alpha and beta proteins (a/b)	S-adenosyl-L-methionine-dependent methyltransferases	S-adenosyl-L-methionine-dependent methyltransferases	Mycolic acid cyclopropane synthase	Methoxy mycolic acid synthase 4, Mma4	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	S-adenosyl-L-methionine-dependent methyltransferases	8041080	3000118	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CMAS	e3ha5A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: S-adenosyl-L-methionine-dependent methyltransferases	F: CMAS	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.150	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Vaccinia Virus protein VP39	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02353	Mycolic acid cyclopropane synthetase (CMAS)	Mycolic acid cyclopropane synthetase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	METHOXY MYCOLIC ACID SYNTHASE 4	transferase activity, transferring one-carbon groups transferase activity methyltransferase activity S-adenosylmethionine-dependent methyltransferase activity catalytic activity	methylation metabolic process oxoacid metabolic process cellular biosynthetic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis organic substance metabolic process mycolic acid biosynthetic process organic substance biosynthetic process Actinobacterium-type cell wall biogenesis methylation metabolic process oxoacid metabolic process cellular biosynthetic process cell wall organization or biogenesis lipid biosynthetic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process cellular component biogenesis organic substance metabolic process mycolic acid biosynthetic process organic substance biosynthetic process Actinobacterium-type cell wall biogenesis small molecule metabolic process cellular component organization or biogenesis peptidoglycan-based cell wall biogenesis fatty acid metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process cellular metabolic process mycolic acid metabolic process carboxylic acid metabolic process primary metabolic process fatty acid biosynthetic process macromolecule biosynthetic process cell wall biogenesis biosynthetic process cell wall macromolecule biosynthetic process cellular lipid metabolic process cellular process macromolecule metabolic process monocarboxylic acid metabolic process lipid metabolic process	cell periphery plasma membrane membrane cellular anatomical entity external encapsulating structure cell wall peptidoglycan-based cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A	IPR003333	Cyclopropane mycolic acid synthase	Family
A	IPR047672	Cyclopropane mycolic acid synthase, actinobacteria	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.