3H4J

crystal structure of pombe AMPK KDAID fragment

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth B]	d3h4jb1	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Fission yeast (Schizosaccharomyces pombe ) [TaxId: 4896 ],	SCOPe (2.08)
A [auth B]	d3h4jb2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Fission yeast (Schizosaccharomyces pombe ) [TaxId: 4896 ],	SCOPe (2.08)
B [auth A]	d3h4ja1	Alpha and beta proteins (a+b)	Protein kinase-like (PK-like)	Protein kinase-like (PK-like)	automated matches	automated matches	Fission yeast (Schizosaccharomyces pombe ) [TaxId: 4896 ],	SCOPe (2.08)
B [auth A]	d3h4ja2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Fission yeast (Schizosaccharomyces pombe ) [TaxId: 4896 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2 Family	MARK4 variant UBA domain-like	8051012	4007155	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Family	Protein kinases catalytic domain-like	8090059	4003661	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	UBA-like	8090058	3001235	SCOP2 (2022-06-29)
A [auth B]	SCOP2 Superfamily	Protein kinase-like (PK-like)	8090060	3000066	SCOP2 (2022-06-29)
B [auth A]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8090060	3000066	SCOP2B (2022-06-29)
B [auth A]	SCOP2B Superfamily	UBA-like	8090058	3001235	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	UBA_2	e3h4jB5	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: UBA_2	ECOD (1.6)
A [auth B]	Pkinase_Tyr	e3h4jB4	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B [auth A]	UBA_2	e3h4jA1	A: alpha arrays	X: RuvA-C	H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology)	T: RuvA-C, UBA, CRAL/TRIO-N, HBS1	F: UBA_2	ECOD (1.6)
B [auth A]	Pkinase_Tyr	e3h4jA2	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A [auth B]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
A [auth B]	1.10.8.10	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)
B [auth A]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B [auth A]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B [auth A]	1.10.8.10	Mainly Alpha	Orthogonal Bundle	Helicase, Ruva Protein	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF08587	Ubiquitin associated domain (UBA) (UBA_2)	Ubiquitin associated domain (UBA)	This is a UBA (ubiquitin associated) domain [1]. Ubiquitin is involved in intracellular proteolysis.	Domain
A [auth B], B [auth A]	PF00069	Protein kinase domain (Pkinase)	Protein kinase domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	SNF1-like protein kinase ssp2	catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity protein serine kinase activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein serine/threonine kinase activity	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process translation gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of cytoplasmic translation negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process cytoplasmic translation metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of cytoplasmic translation regulation of metabolic process carbohydrate metabolic process cellular response to stimulus response to stimulus cellular response to sterol depletion signaling response to sterol depletion cell communication SREBP signaling pathway cellular response to stress response to stress ER-nucleus signaling pathway signal transduction calmodulin dependent kinase signaling pathway intracellular signal transduction calcium-mediated signaling intracellular signaling cassette CAMKK-AMPK signaling cascade multicellular organismal process regulation of developmental process regulation of reproductive process reproductive process positive regulation of biological process developmental process involved in reproduction positive regulation of developmental process multicellular organism development positive regulation of ascus development anatomical structure development reproductive structure development regulation of multicellular organismal process regulation of ascus development system development positive regulation of reproductive process developmental process spore-bearing structure development reproductive system development regulation of spore-bearing organ development positive regulation of spore-bearing organ development positive regulation of multicellular organismal process ascus development cell cycle switching sexual reproduction positive regulation of cell cycle switching, mitotic to meiotic cell cycle negative regulation of cell cycle negative regulation of mitotic cell cycle mitotic cell cycle regulation of mitotic cell cycle regulation of cell cycle switching, mitotic to meiotic cell cycle positive regulation of cell cycle process cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process regulation of meiotic cell cycle regulation of cell cycle process meiotic cell cycle positive regulation of meiotic cell cycle positive regulation of cell cycle cell cycle switching, mitotic to meiotic cell cycle regulation of conjugation with cellular fusion conjugation with cellular fusion induction of conjugation with cellular fusion positive regulation of conjugation with cellular fusion negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction negative regulation of cell communication negative regulation of TORC1 signaling regulation of intracellular signal transduction negative regulation of TOR signaling regulation of TORC1 signaling TOR signaling regulation of signaling regulation of TOR signaling negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus regulation of cell communication TORC1 signaling phosphorylation phosphate-containing compound metabolic process phosphorus metabolic process positive regulation of macromolecule biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body microtubule cytoskeleton non-membrane-bounded organelle mitotic spindle pole body protein kinase complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle spindle pole body microtubule cytoskeleton non-membrane-bounded organelle mitotic spindle pole body protein kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex transferase complex intracellular protein-containing complex nucleotide-activated protein kinase complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR017441	Protein kinase, ATP binding site	Binding Site
A [auth B], B [auth A]	IPR013896	Carbon catabolite-derepressing protein kinase, ubiquitin-associated domain	Domain
A [auth B], B [auth A]	IPR032270	AMPK, C-terminal adenylate sensor domain	Domain
A [auth B], B [auth A]	IPR000719	Protein kinase domain	Domain
A [auth B], B [auth A]	IPR015940	Ubiquitin-associated domain	Domain
A [auth B], B [auth A]	IPR028375	KA1 domain/Ssp2, C-terminal	Homologous Superfamily
A [auth B], B [auth A]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth B], B [auth A]	IPR008271	Serine/threonine-protein kinase, active site	Active Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.