3H1I

Stigmatellin and antimycin bound cytochrome bc1 complex from chicken

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8042108	3000517	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8042105	3000966	SCOP2B (2022-06-29)
M [auth P]	SCOP2B Superfamily	Transmembrane di-heme cytochromes	8042108	3000517	SCOP2B (2022-06-29)
M [auth P]	SCOP2B Superfamily	a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8042105	3000966	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8068589	3000779	SCOP2B (2022-06-29)
T [auth W]	SCOP2B Superfamily	Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8068589	3000779	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8068577	3000797	SCOP2B (2022-06-29)
P [auth S]	SCOP2B Superfamily	14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	8068577	3000797	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	Cytochrom_B_C	e3h1iC1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
C	Cytochrome_B	e3h1iC2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
M [auth P]	Cytochrom_B_C	e3h1iP1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: Cytochrom_B_C	ECOD (1.6)
M [auth P]	Cytochrome_B	e3h1iP2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: Cytochrome_B	ECOD (1.6)
E	Rieske_cytochrome_bc1,Rieske_6	e3h1iE3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1,Rieske_6	ECOD (1.6)
E	UCR_TM	e3h1iE2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
O [auth R]	Rieske_cytochrome_bc1,Rieske_6	e3h1iR3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: Rieske_cytochrome_bc1,Rieske_6	ECOD (1.6)
O [auth R]	UCR_TM	e3h1iR2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: UCR_TM	ECOD (1.6)
G	UcrQ	e3h1iG1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
Q [auth T]	UcrQ	e3h1iT1	A: extended segments	X: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UcrQ	ECOD (1.6)
H	UCR_hinge	e3h1iH1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
R [auth U]	UCR_hinge	e3h1iU1	A: alpha bundles	X: cytochrome bc1 complex 11 kDa protein-like	H: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_hinge	ECOD (1.6)
I	Ubiq-Cytc-red_N	e3h1iI1	A: extended segments	X: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	H: Ubiquinol-cytochrome c reductase 8 kDa protein (From Topology)	T: Ubiquinol-cytochrome c reductase 8 kDa protein	F: Ubiq-Cytc-red_N	ECOD (1.6)
A	Peptidase_M16_C	e3h1iA2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
A	Peptidase_M16	e3h1iA1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
K [auth N]	Peptidase_M16_C	e3h1iN2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
K [auth N]	Peptidase_M16	e3h1iN1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
J	UCR_UQCRX_QCR9	e3h1iJ1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
T [auth W]	UCR_UQCRX_QCR9	e3h1iW1	A: extended segments	X: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_UQCRX_QCR9	ECOD (1.6)
B	Peptidase_M16_C	e3h1iB2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
B	Peptidase_M16	e3h1iB1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
L [auth O]	Peptidase_M16_C	e3h1iO2	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16_C	ECOD (1.6)
L [auth O]	Peptidase_M16	e3h1iO1	A: a+b two layers	X: LuxS, MPP, ThrRS/AlaRS common domain	H: LuxS, MPP, ThrRS/AlaRS common domain	T: LuxS/MPP-like metallohydrolase	F: Peptidase_M16	ECOD (1.6)
D	Cytochrom_C1_N	e3h1iD1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
D	Cytochrom_C1_C	e3h1iD2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
N [auth Q]	Cytochrom_C1_N	e3h1iQ1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: Cytochrom_C1_N	ECOD (1.6)
N [auth Q]	Cytochrom_C1_C	e3h1iQ2	A: extended segments	X: cytochrome c1 transmembrane anchor (From Topology)	H: cytochrome c1 transmembrane anchor (From Topology)	T: cytochrome c1 transmembrane anchor	F: Cytochrom_C1_C	ECOD (1.6)
F	UCR_14kD	e3h1iF1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)
P [auth S]	UCR_14kD	e3h1iS1	A: alpha arrays	X: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: UCR_14kD	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
M [auth P]	1.20.810.10	Mainly Alpha	Up-down Bundle	Cytochrome Bc1 Complex	Chain C	CATH (4.3.0)
E	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
E	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
O [auth R]	1.20.5.270	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Ubiquinol cytochrome reductase, transmembrane domain	CATH (4.3.0)
O [auth R]	2.102.10.10	Mainly Beta	3-layer Sandwich	Rieske Iron-sulfur Protein	Rieske [2Fe-2S] iron-sulphur domain	CATH (4.3.0)
G	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)
Q [auth T]	1.20.5.210	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 8	CATH (4.3.0)
H	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)
R [auth U]	1.10.287.20	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Ubiquinol-cytochrome C reductase hinge domain	CATH (4.3.0)
I	2.10.210.10	Mainly Beta	Ribbon	Cytochrome Bc1 Complex	Chain I	CATH (4.3.0)
S [auth V]	2.10.210.10	Mainly Beta	Ribbon	Cytochrome Bc1 Complex	Chain I	CATH (4.3.0)
A	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
K [auth N]	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
J	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)
T [auth W]	1.20.5.260	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome b-c1 complex subunit 9	CATH (4.3.0)
B	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
L [auth O]	3.30.830.10	Alpha Beta	2-Layer Sandwich	Cytochrome Bc1 Complex	Chain A, domain 1	CATH (4.3.0)
D	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
D	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
N [auth Q]	1.10.760.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain D, domain 2	CATH (4.3.0)
N [auth Q]	1.20.5.100	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces	Cytochrome c1, transmembrane anchor, C-terminal	CATH (4.3.0)
F	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)
P [auth S]	1.10.1090.10	Mainly Alpha	Orthogonal Bundle	Cytochrome Bc1 Complex	Chain F	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, M [auth P]	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
C, M [auth P]	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
E, O [auth R]	PF02921	Ubiquinol cytochrome reductase transmembrane region (UCR_TM)	Ubiquinol cytochrome reductase transmembrane region	-	Family
E, O [auth R]	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
I, S [auth V]	PF09165	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal (Ubiq-Cytc-red_N)	Ubiquinol-cytochrome c reductase 8 kDa, N-terminal	Members of this family adopt a structure consisting of many antiparallel beta sheets, with few alpha helices, in a non-globular arrangement. They are required for proper functioning of the respiratory chain [1].	Domain
A, K [auth N]	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
A, K [auth N]	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
J, T [auth W]	PF05365	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like (UCR_UQCRX_QCR9)	Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like	-	Family
B, L [auth O]	PF05193	Peptidase M16 inactive domain (Peptidase_M16_C)	Peptidase M16 inactive domain	Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp [1].	Domain
B, L [auth O]	PF00675	Insulinase (Peptidase family M16) (Peptidase_M16)	Insulinase (Peptidase family M16)	-	Family
D, N [auth Q]	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family
F, P [auth S]	PF02271	Ubiquinol-cytochrome C reductase complex 14kD subunit (UCR_14kD)	Ubiquinol-cytochrome C reductase complex 14kD subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, M [auth P]	Cytochrome b	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport response to oxidative stress response to stimulus response to stress	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane organelle inner membrane cytochrome complex membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane organelle inner membrane cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope respirasome organelle membrane
E, O [auth R]	Cytochrome b-c1 complex subunit Rieske, mitochondrial	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
G, Q [auth T]	UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C	-	-	-
H, R [auth U]	UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 11 KDA PROTEIN	-	-	-
I, S [auth V]	Cytochrome b-c1 complex subunit Rieske, mitochondrial	oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity oxidoreductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
A, K [auth N]	UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN I, MITOCHONDRIAL	cation binding ion binding binding metal ion binding small molecule binding	-	-
J, T [auth W]	UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.2 KDA PROTEIN	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane
B, L [auth O]	UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX CORE PROTEIN 2, MITOCHONDRIAL	cation binding ion binding binding metal ion binding small molecule binding	-	-
D, N [auth Q]	CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	-	membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm membrane-bounded organelle mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane intracellular organelle organelle envelope mitochondrial envelope organelle cytoplasm organelle membrane respirasome
F, P [auth S]	UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KDA PROTEIN	-	aerobic respiration cellular respiration aerobic electron transport chain oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process ATP synthesis coupled electron transport electron transport chain generation of precursor metabolites and energy mitochondrial electron transport, ubiquinol to cytochrome c respiratory electron transport chain metabolic process cellular process mitochondrial ATP synthesis coupled electron transport	membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle membrane-bounded organelle respiratory chain complex protein-containing complex mitochondrial respiratory chain complex III mitochondrial membrane intracellular anatomical structure organelle inner membrane mitochondrion cytochrome complex mitochondrial respirasome membrane protein complex transporter complex respiratory chain complex III intracellular organelle organelle envelope oxidoreductase complex mitochondrial protein-containing complex catalytic complex membrane cellular anatomical entity intracellular membrane-bounded organelle mitochondrial inner membrane inner mitochondrial membrane protein complex transmembrane transporter complex mitochondrial envelope organelle respirasome cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, M [auth P]	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
C, M [auth P]	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
C, M [auth P]	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
C, M [auth P]	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
C, M [auth P]	IPR005798	Cytochrome b/b6, C-terminal	Domain
C, M [auth P]	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
C, M [auth P]	IPR030689	Cytochrome b	Family
C, M [auth P]	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
E, O [auth R]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
E, O [auth R]	IPR014349	Rieske iron-sulphur protein	Family
E, O [auth R]	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
E, O [auth R]	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
E, O [auth R]	IPR015248	Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal	Domain
E, O [auth R]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
E, O [auth R]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
E, O [auth R]	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
E, O [auth R]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
I, S [auth V]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
I, S [auth V]	IPR014349	Rieske iron-sulphur protein	Family
I, S [auth V]	IPR011070	Globular protein, non-globular alpha/beta subunit	Homologous Superfamily
I, S [auth V]	IPR004192	Cytochrome b-c1 complex subunit Rieske, transmembrane domain	Domain
I, S [auth V]	IPR015248	Ubiquinol-cytochrome c reductase iron-sulphur subunit, N-terminal	Domain
I, S [auth V]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
I, S [auth V]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
I, S [auth V]	IPR037008	Cytochrome bc1 complex subunit Rieske, transmembrane domain superfamily	Homologous Superfamily
I, S [auth V]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
A, K [auth N]	IPR007863	Peptidase M16, C-terminal	Domain
A, K [auth N]	IPR011765	Peptidase M16, N-terminal	Domain
A, K [auth N]	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
J, T [auth W]	IPR008027	Cytochrome b-c1 complex subunit 9	Family
J, T [auth W]	IPR036656	Cytochrome b-c1 complex subunit 9 superfamily	Homologous Superfamily
B, L [auth O]	IPR007863	Peptidase M16, C-terminal	Domain
B, L [auth O]	IPR011765	Peptidase M16, N-terminal	Domain
B, L [auth O]	IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	Homologous Superfamily
D, N [auth Q]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
D, N [auth Q]	IPR002326	Cytochrome c1	Family
D, N [auth Q]	IPR009056	Cytochrome c-like domain	Domain
D, N [auth Q]	IPR021157	Cytochrome c1, transmembrane anchor, C-terminal	Homologous Superfamily
F, P [auth S]	IPR003197	Cytochrome b-c1 complex subunit 7	Family
F, P [auth S]	IPR036544	Cytochrome b-c1 complex subunit 7 superfamily	Homologous Superfamily

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
C, D, E, F, I C, D, E, F, I, J, M [auth P], N [auth Q], O [auth R], P [auth S], S [auth V], T [auth W]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
C, D, E, F, I C, D, E, F, I, J, M [auth P], N [auth Q], O [auth R], P [auth S], S [auth V], T [auth W]	MemProtMD	Annotated as membrane protein by MemProtMD