3GRO

Human palmitoyl-protein thioesterase 1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Membrane Protein Annotation: OPM

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3grob_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Thioesterases	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3groa_	Alpha and beta proteins (a/b)	alpha/beta-Hydrolases	alpha/beta-Hydrolases	Thioesterases	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	alpha/beta-Hydrolases	8081300	3000102	SCOP2B (2022-06-29)
A	SCOP2 Family	Thioesterases	8081299	4000718	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	alpha/beta-Hydrolases	8081300	3000102	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Palm_thioest	e3groB1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Palm_thioest	ECOD (1.6)
A	Palm_thioest	e3groA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Palm_thioest	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02089	Palmitoyl protein thioesterase (Palm_thioest)	Palmitoyl protein thioesterase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Palmitoyl-protein thioesterase 1	palmitoyl-(protein) hydrolase activity palmitoyl hydrolase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity catalytic activity binding ion binding anion binding phospholipid binding lipid binding lysophosphatidic acid binding carbohydrate derivative binding palmitoyl-(protein) hydrolase activity palmitoyl hydrolase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds thiolester hydrolase activity hydrolase activity catalytic activity binding ion binding anion binding phospholipid binding lipid binding lysophosphatidic acid binding carbohydrate derivative binding small molecule binding sulfatide binding glycolipid binding	biological regulation regulation of synapse structure or activity regulation of biological quality developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development adult locomotory behavior biological regulation regulation of synapse structure or activity regulation of biological quality developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development adult locomotory behavior behavior adult behavior locomotory behavior membrane organization cellular component organization cellular process membrane raft organization cellular component organization or biogenesis regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death trans-synaptic signaling cellular localization neurotransmitter secretion transport signaling secretion cell-cell signaling export from cell neurotransmitter transport establishment of localization cell communication chemical synaptic transmission localization signal release from synapse synaptic signaling secretion by cell signal release anterograde trans-synaptic signaling establishment of localization in cell protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization nucleoside bisphosphate metabolic process ribonucleoside bisphosphate biosynthetic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process purine ribonucleotide biosynthetic process nucleobase-containing compound metabolic process ribonucleotide biosynthetic process organic substance biosynthetic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process thioester metabolic process fatty-acyl-CoA metabolic process phosphorus metabolic process ribose phosphate biosynthetic process nucleoside phosphate metabolic process cellular metabolic process primary metabolic process amide biosynthetic process nucleotide metabolic process organic cyclic compound metabolic process sulfur compound biosynthetic process biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process metabolic process purine ribonucleotide metabolic process purine nucleotide biosynthetic process ribose phosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process thioester biosynthetic process cellular biosynthetic process lipid biosynthetic process fatty-acyl-CoA biosynthetic process organic substance metabolic process purine nucleotide metabolic process acyl-CoA metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine-containing compound biosynthetic process acyl-CoA biosynthetic process purine nucleoside bisphosphate biosynthetic process amide metabolic process carbohydrate derivative biosynthetic process organonitrogen compound metabolic process nucleoside bisphosphate biosynthetic process fatty acid derivative biosynthetic process nucleobase-containing compound biosynthetic process fatty acid derivative metabolic process purine-containing compound metabolic process organophosphate metabolic process lipid metabolic process organonitrogen compound catabolic process catabolic process protein catabolic process macromolecule catabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process lipoprotein metabolic process macromolecule deacylation protein deacylation macromolecule modification macromolecule depalmitoylation protein depalmitoylation protein modification process lipoprotein catabolic process regulation of growth regulation of cellular component organization growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth regulation of localization import into cell positive regulation of cellular component organization positive regulation of biological process vesicle-mediated transport positive regulation of endocytosis positive regulation of cellular process regulation of endocytosis positive regulation of pinocytosis regulation of transport regulation of vesicle-mediated transport positive regulation of transport regulation of pinocytosis pinocytosis endocytosis neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process response to stimulus homeostatic process intracellular pH reduction regulation of intracellular pH lysosome organization vacuolar acidification lysosomal lumen acidification intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of lysosomal lumen pH regulation of cellular pH intracellular monoatomic ion homeostasis vacuole organization lytic vacuole organization organelle organization cellular homeostasis chemical homeostasis lipid catabolic process positive regulation of receptor-mediated endocytosis regulation of receptor-mediated endocytosis receptor-mediated endocytosis sphingolipid catabolic process membrane lipid metabolic process sphingolipid metabolic process membrane lipid catabolic process cellular lipid catabolic process cellular catabolic process cellular lipid metabolic process sensory perception of light stimulus system process sensory perception nervous system process visual perception learning learning or memory cognition associative learning grooming behavior cellular developmental process cell development generation of neurons neurogenesis neuron differentiation cell differentiation neuron development	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure lytic vacuole membrane-enclosed lumen vacuolar lumen vacuole intracellular membrane-bounded organelle lysosomal lumen intracellular organelle lumen intracellular organelle organelle lumen organelle cytoplasm lysosome extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol membrane microdomain membrane raft somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection Golgi apparatus endomembrane system cell body neuronal cell body axon transport vesicle synapse intracellular vesicle presynapse cytoplasmic vesicle synaptic vesicle cell junction secretory vesicle exocytic vesicle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR002472	Palmitoyl protein thioesterase	Family
A, B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P50897	neuronal ceroid lipofuscinosis neuronal ceroid lipofuscinosis 1 Ceroid Lipofuscinosis, Neuronal, 1 infantile neuronal ceroid lipofuscinosis plasma cell myeloma astrocytic tumor leukodystrophy neurodegenerative disease ovarian cancer tuberculosis breast cancer diabetes mellitus intellectual disability lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia neuronal ceroid lipofuscinosis neuronal ceroid lipofuscinosis 1 Ceroid Lipofuscinosis, Neuronal, 1 infantile neuronal ceroid lipofuscinosis plasma cell myeloma astrocytic tumor leukodystrophy neurodegenerative disease ovarian cancer tuberculosis breast cancer diabetes mellitus intellectual disability lymphoplasmacytic lymphoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis Duchenne muscular dystrophy inborn errors of metabolism invasive ductal breast carcinoma lysosomal storage disease

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Monotopic/peripheral	Alpha/Beta monotopic/peripheral	Alpha/beta-hydrolases	Thioesterases

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.