3GMJ

Crystal structure of MAD MH2 domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth D]	d3gmjd_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
B	d3gmjb_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
C [auth A]	d3gmja_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)
D [auth C]	d3gmjc_	All beta proteins	SMAD/FHA domain	SMAD/FHA domain	automated matches	automated matches	Fruit fly (Drosophila melanogaster ) [TaxId: 7227 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth D]	SCOP2B Superfamily	SMAD/FHA domain-like	8083630	3000137	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SMAD/FHA domain-like	8083630	3000137	SCOP2B (2022-06-29)
C [auth A]	SCOP2 Family	SMAD domain	8083629	4002600	SCOP2 (2022-06-29)
C [auth A]	SCOP2 Superfamily	SMAD/FHA domain-like	8083630	3000137	SCOP2 (2022-06-29)
D [auth C]	SCOP2B Superfamily	SMAD/FHA domain-like	8083630	3000137	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	MH2	e3gmjD1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: MH2	ECOD (1.6)
B	MH2	e3gmjB1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: MH2	ECOD (1.6)
C [auth A]	MH2	e3gmjA1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: MH2	ECOD (1.6)
D [auth C]	MH2	e3gmjC1	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: MH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth D]	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
B	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
C [auth A]	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)
D [auth C]	2.60.200.10	Mainly Beta	Sandwich	Tumour Suppressor Smad4		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D], B, C [auth A], D [auth C]	PF03166	MH2 domain (MH2)	MH2 domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D], B, C [auth A], D [auth C]	Protein mothers against dpp	co-SMAD binding SMAD binding protein binding binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity I-SMAD binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity co-SMAD binding SMAD binding protein binding binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity I-SMAD binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity cation binding ion binding metal ion binding small molecule binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding transcription coactivator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development imaginal disc morphogenesis instar larval or pupal development metamorphosis anatomical structure morphogenesis instar larval or pupal morphogenesis imaginal disc development developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development imaginal disc morphogenesis instar larval or pupal development metamorphosis anatomical structure morphogenesis instar larval or pupal morphogenesis imaginal disc development post-embryonic animal morphogenesis post-embryonic development animal organ morphogenesis germ-line stem cell population maintenance maintenance of cell number stem cell population maintenance multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells intestinal stem cell homeostasis sensory organ development eye development visual system development eye morphogenesis compound eye development compound eye morphogenesis sensory organ morphogenesis sensory system development sexual reproduction cellular developmental process stem cell division reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction germ-line stem cell division gamete generation cell differentiation germ cell development cellular process cell division anterior/posterior pattern specification, imaginal disc anterior/posterior pattern specification wing disc development pattern specification process wing disc anterior/posterior pattern formation regionalization imaginal disc pattern formation wing disc pattern formation somatic stem cell population maintenance central nervous system development ventral cord development nervous system development regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription regulation of biological process negative regulation of transcription by RNA polymerase II cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process positive regulation of neuromuscular junction development regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process cellular component organization regulation of synapse organization cell junction organization neuromuscular junction development regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality regulation of neuromuscular junction development positive regulation of cellular process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of developmental process negative regulation of salivary gland boundary specification gland development animal organ formation regulation of multicellular organismal process negative regulation of developmental process salivary gland development formation of anatomical boundary salivary gland boundary specification regulation of salivary gland boundary specification anatomical structure formation involved in morphogenesis formation of animal organ boundary exocrine system development negative regulation of multicellular organismal process cellular response to stimulus cellular response to BMP stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus cell surface receptor signaling pathway response to stimulus signaling response to endogenous stimulus cell communication cellular response to endogenous stimulus response to BMP transforming growth factor beta receptor superfamily signaling pathway signal transduction response to growth factor BMP signaling pathway enzyme-linked receptor protein signaling pathway compound eye photoreceptor fate commitment photoreceptor cell differentiation neurogenesis neuron differentiation photoreceptor cell fate specification photoreceptor cell fate commitment eye photoreceptor cell differentiation neuron fate specification R8 cell differentiation R8 cell fate commitment eye photoreceptor cell fate commitment neuron fate commitment cell fate specification R8 cell fate specification generation of neurons compound eye photoreceptor cell differentiation cell fate commitment histoblast morphogenesis cell morphogenesis appendage development post-embryonic appendage morphogenesis imaginal disc-derived wing morphogenesis imaginal disc-derived appendage morphogenesis wing disc morphogenesis appendage morphogenesis imaginal disc-derived appendage development blastoderm segmentation embryonic pattern specification segmentation embryo development trunk segmentation leg disc development leg disc morphogenesis imaginal disc-derived leg morphogenesis epithelium development oogenesis female gamete generation tissue development epithelial cell differentiation follicle cell of egg chamber development epithelial cell development intracellular signal transduction SMAD protein signal transduction intracellular signaling cassette regulation of cell cycle phase transition negative regulation of cell cycle cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition cell cycle regulation of cell cycle cell cycle process negative regulation of G1/S transition of mitotic cell cycle negative regulation of mitotic cell cycle phase transition regulation of cell cycle process negative regulation of cell cycle G1/S phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition imaginal disc-derived wing vein morphogenesis positive regulation of nervous system development regulation of growth developmental growth cellular component biogenesis positive regulation of developmental process cellular component assembly regulation of synaptic assembly at neuromuscular junction positive regulation of developmental growth positive regulation of synaptic assembly at neuromuscular junction regulation of cell junction assembly positive regulation of multicellular organismal process synapse assembly positive regulation of synapse assembly regulation of nervous system development cell junction assembly regulation of synapse assembly regulation of multicellular organismal development regulation of developmental growth positive regulation of cellular component biogenesis growth regulation of cellular component biogenesis positive regulation of cell junction assembly positive regulation of growth synaptic assembly at neuromuscular junction regulation of cell differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus heteromeric SMAD protein complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle SMAD protein complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus heteromeric SMAD protein complex nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle SMAD protein complex organelle RNA polymerase II transcription repressor complex transcription repressor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D], B, C [auth A], D [auth C]	IPR036578	SMAD MH1 domain superfamily	Homologous Superfamily
A [auth D], B, C [auth A], D [auth C]	IPR017855	SMAD-like domain superfamily	Homologous Superfamily
A [auth D], B, C [auth A], D [auth C]	IPR013019	MAD homology, MH1	Domain
A [auth D], B, C [auth A], D [auth C]	IPR013790	Dwarfin	Family
A [auth D], B, C [auth A], D [auth C]	IPR003619	MAD homology 1, Dwarfin-type	Domain
A [auth D], B, C [auth A], D [auth C]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
A [auth D], B, C [auth A], D [auth C]	IPR001132	SMAD domain, Dwarfin-type	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.