Annotations: 3G65

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DNA clamp	8056956	3000780	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	DNA clamp	8056955	3000780	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DNA clamp	8056957	3000780	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	DNA clamp	8056958	3000780	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DNA clamp	8056954	3000780	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	DNA clamp	8056953	3000780	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Rad9	e3g65A1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: Rad9	ECOD (1.6)
B	Rad1	e3g65B1	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: Rad1	ECOD (1.6)
C	Hus1_C	e3g65C4	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: Hus1_C	ECOD (1.6)
C	Hus1_N	e3g65C3	A: a+b two layers	X: DNA clamp (From Topology)	H: DNA clamp (From Topology)	T: DNA clamp	F: Hus1_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.70.10.10	Alpha Beta	Box	Proliferating Cell Nuclear Antigen		CATH (4.3.0)
B	3.70.10.10	Alpha Beta	Box	Proliferating Cell Nuclear Antigen		CATH (4.3.0)
C	3.70.10.10	Alpha Beta	Box	Proliferating Cell Nuclear Antigen		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04139	Rad9 (Rad9)	Rad9	-	Family
B	PF02144	Repair protein Rad1/Rec1/Rad17 (Rad1)	Repair protein Rad1/Rec1/Rad17	-	Family
C	PF04005	Hus1-like protein (Hus1)	Hus1-like protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cell cycle checkpoint control protein RAD9A	double-stranded DNA 3'-5' DNA exonuclease activity DNA exonuclease activity catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity double-stranded DNA exodeoxyribonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds 3'-5'-DNA exonuclease activity catalytic activity double-stranded DNA 3'-5' DNA exonuclease activity DNA exonuclease activity catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity double-stranded DNA exodeoxyribonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds 3'-5'-DNA exonuclease activity catalytic activity exonuclease activity SH3 domain binding protein binding binding protein domain specific binding kinase binding enzyme binding protein kinase binding histone deacetylase binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of cellular response to stress regulation of signal transduction regulation of intrinsic apoptotic signaling pathway in response to DNA damage cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of cellular response to stress regulation of signal transduction regulation of intrinsic apoptotic signaling pathway in response to DNA damage regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of response to stress intrinsic apoptotic signaling pathway in response to DNA damage signal transduction intrinsic apoptotic signaling pathway positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of programmed cell death regulation of apoptotic process biological regulation positive regulation of intracellular signal transduction cell death positive regulation of apoptotic process apoptotic signaling pathway regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair regulation of cell cycle phase transition negative regulation of biological process negative regulation of cell cycle cell cycle phase transition negative regulation of cellular process negative regulation of cell cycle phase transition cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus DNA damage checkpoint signaling mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling mitotic intra-S DNA damage checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process signal transduction in response to DNA damage	membrane-bounded organelle protein-containing complex intracellular anatomical structure condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle checkpoint clamp complex condensed chromosome non-membrane-bounded organelle nuclear lumen cytoplasm nucleoplasm
B	Cell cycle checkpoint protein RAD1	double-stranded DNA 3'-5' DNA exonuclease activity DNA exonuclease activity catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity double-stranded DNA exodeoxyribonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds 3'-5'-DNA exonuclease activity catalytic activity double-stranded DNA 3'-5' DNA exonuclease activity DNA exonuclease activity catalytic activity, acting on a nucleic acid 3'-5' exonuclease activity double-stranded DNA exodeoxyribonuclease activity hydrolase activity DNA exonuclease activity, producing 5'-phosphomonoesters DNA nuclease activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds 3'-5'-DNA exonuclease activity catalytic activity exonuclease activity DNA binding binding organic cyclic compound binding damaged DNA binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organismal process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organismal process head development animal organ development brain development nervous system development substantia nigra development multicellular organism development central nervous system development midbrain development anatomical structure development neural nucleus development system development primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process macromolecule metabolic process DNA repair regulation of cellular process regulation of cell cycle phase transition regulation of cellular component organization sexual reproduction signaling regulation of reproductive process reproductive process meiotic recombination checkpoint signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition meiotic cell cycle process intracellular signal transduction cell communication cellular component organization negative regulation of cellular process negative regulation of cell cycle phase transition meiotic nuclear division signal transduction cell cycle cellular component organization or biogenesis regulation of cell cycle negative regulation of meiotic nuclear division cell cycle process regulation of biological process regulation of meiotic cell cycle negative regulation of cellular component organization regulation of cell cycle process meiotic cell cycle organelle fission biological regulation negative regulation of cell cycle process meiotic cell cycle checkpoint signaling regulation of organelle organization cell cycle checkpoint signaling regulation of meiotic nuclear division organelle organization nuclear division negative regulation of nuclear division negative regulation of organelle organization negative regulation of reproductive process regulation of nuclear division negative regulation of meiotic cell cycle response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus DNA damage checkpoint signaling DNA integrity checkpoint signaling signal transduction in response to DNA damage	membrane-bounded organelle protein-containing complex intracellular anatomical structure condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure condensed nuclear chromosome nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle checkpoint clamp complex condensed chromosome non-membrane-bounded organelle nuclear lumen nucleoplasm
C	Checkpoint protein HUS1	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process mitotic DNA replication checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair response to light stimulus response to radiation response to abiotic stimulus response to UV sexual reproduction reproductive process meiotic cell cycle process meiotic cell cycle meiotic cell cycle checkpoint signaling meiotic DNA integrity checkpoint signaling regulation of protein modification process regulation of protein phosphorylation regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process regulation of metabolic process nucleotide-excision repair response to ionizing radiation cellular response to ionizing radiation cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus DNA damage checkpoint signaling mitotic DNA damage checkpoint signaling mitotic intra-S DNA damage checkpoint signaling signal transduction in response to DNA damage developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development telomere organization chromosome organization telomere maintenance cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex condensed nuclear chromosome nuclear protein-containing complex nuclear chromosome chromosome checkpoint clamp complex condensed chromosome cytoplasm cytosol site of double-strand break site of DNA damage nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR046938	DNA clamp superfamily	Homologous Superfamily
A	IPR026584	Rad9	Family
A	IPR007268	Rad9/Ddc1	Family
B	IPR046938	DNA clamp superfamily	Homologous Superfamily
B	IPR003021	Rad1/Rec1/Rad17	Family
B	IPR003011	Cell cycle checkpoint protein, Rad1	Family
C	IPR046938	DNA clamp superfamily	Homologous Superfamily
C	IPR016580	Cell cycle checkpoint, Hus1	Family
C	IPR007150	Checkpoint protein Hus1/Mec3	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q99638	Neoplasms, Second Primary malignant mesothelioma osteosarcoma
B	Pharos: O60671	astrocytic tumor ovarian cancer tuberculosis invasive ductal breast carcinoma pituitary cancer osteosarcoma psoriasis
C	Pharos: O60921	glioblastoma peripheral nervous system disease osteosarcoma peripheral neuropathy ovarian cancer Sjogren syndrome

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.