Annotations: 3G5B

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	UPA domain-like	8046642	4005210	SCOP2 (2022-06-29)
A	SCOP2 Family	DEATH domain DD	8102954	4000378	SCOP2 (2022-06-29)
A	SCOP2 Family	ZU5 domain	8048256	4000379	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	UPA domain-like	8102973	3002775	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	DEATH domain	8102955	3000069	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ZU5 domain-like	8102948	3002026	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	UPA	e3g5bA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: UPA domain	F: UPA	ECOD (1.6)
A	ZU5	e3g5bA1	A: beta sandwiches	X: Glycosyl hydrolase domain-like	H: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related (From Topology)	T: ZU5/Nup98-C/GAIN-B autoproteolytic domain-related	F: ZU5	ECOD (1.6)
A	Death	e3g5bA3	A: alpha arrays	X: DEATH domain	H: DEATH domain (From Topology)	T: DEATH domain	F: Death	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00791	ZU5 domain (ZU5)	ZU5 domain	-	Family
A	PF00531	Death domain (Death)	Death domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Netrin receptor UNC5B	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity netrin receptor activity	cellular response to stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cellular process response to stimulus signal transduction in absence of ligand negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand cell communication negative regulation of extrinsic apoptotic signaling pathway cellular response to stimulus negative regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cellular process response to stimulus signal transduction in absence of ligand negative regulation of signaling signaling negative regulation of biological process regulation of signal transduction regulation of programmed cell death negative regulation of cell communication extrinsic apoptotic signaling pathway negative regulation of signal transduction in absence of ligand cell communication negative regulation of extrinsic apoptotic signaling pathway negative regulation of apoptotic signaling pathway negative regulation of cellular process extrinsic apoptotic signaling pathway in absence of ligand signal transduction regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of programmed cell death regulation of apoptotic process biological regulation cell death negative regulation of signal transduction regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway negative regulation of apoptotic process regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication cellular process apoptotic process programmed cell death regulation of apoptotic signaling pathway multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cellular component organization neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process plasma membrane bounded cell projection organization axon guidance nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron projection guidance neuron development positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of cellular process positive regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process positive regulation of signaling anterior/posterior axon guidance regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process	cell periphery plasma membrane membrane cellular anatomical entity membrane microdomain membrane raft

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
A	IPR011029	Death-like domain superfamily	Homologous Superfamily
A	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A	IPR003599	Immunoglobulin subtype	Domain
A	IPR003598	Immunoglobulin subtype 2	Domain
A	IPR037936	Netrin receptor UNC5	Family
A	IPR042156	UNC5B, death domain	Domain
A	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily
A	IPR033772	UPA domain	Domain
A	IPR000488	Death domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR007110	Immunoglobulin-like domain	Domain
A	IPR013098	Immunoglobulin I-set	Domain
A	IPR000906	ZU5 domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.