3FRT

The structure of human CHMP3 (residues 8 - 222).

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	IST1/CHMP3-like	8055751	3002301	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	IST1/CHMP3-like	8055751	3002301	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PF03357	e3frtB1	A: alpha bundles	X: Charged multivesicular body protein 3 (CHMP3)-related (From Topology)	H: Charged multivesicular body protein 3 (CHMP3)-related (From Topology)	T: Charged multivesicular body protein 3 (CHMP3)-related	F: PF03357	ECOD (1.6)
A	PF03357	e3frtA1	A: alpha bundles	X: Charged multivesicular body protein 3 (CHMP3)-related (From Topology)	H: Charged multivesicular body protein 3 (CHMP3)-related (From Topology)	T: Charged multivesicular body protein 3 (CHMP3)-related	F: PF03357	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03357	Snf7 (Snf7)	Snf7	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Charged multivesicular body protein 3	ubiquitin-specific protease binding protein binding binding enzyme binding protease binding cation binding ion binding phosphatidylcholine binding phospholipid binding lipid binding quaternary ammonium group binding small molecule binding identical protein binding molecular function inhibitor activity ubiquitin-specific protease binding protein binding binding enzyme binding protease binding cation binding ion binding phosphatidylcholine binding phospholipid binding lipid binding quaternary ammonium group binding small molecule binding identical protein binding molecular function inhibitor activity molecular function regulator activity phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phosphatidylinositol phosphate binding phosphatidylinositol binding	cellular component organization regulation of cellular component size regulation of vesicle size biological regulation cellular process cellular component organization or biogenesis regulation of biological quality regulation of endosome size regulation of anatomical structure size regulation of cytokinesis regulation of biological process regulation of cellular process positive regulation of cell division regulation of cell cycle process cellular component organization regulation of cellular component size regulation of vesicle size biological regulation cellular process cellular component organization or biogenesis regulation of biological quality regulation of endosome size regulation of anatomical structure size regulation of cytokinesis regulation of biological process regulation of cellular process positive regulation of cell division regulation of cell cycle process positive regulation of biological process cytokinesis positive regulation of cell cycle regulation of cell division positive regulation of cytokinesis positive regulation of cell cycle process cell division cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process cellular component disassembly catabolic process macroautophagy protein-containing complex organization cellular metabolic process autophagy protein-containing complex disassembly cellular catabolic process autophagosome maturation metabolic process process utilizing autophagic mechanism membrane organization membrane biogenesis nuclear membrane reassembly membrane assembly nuclear membrane organization cellular component biogenesis nucleus organization organelle organization cellular component assembly nuclear envelope organization endomembrane system organization organonitrogen compound catabolic process organonitrogen compound metabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ubiquitin-dependent protein catabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process establishment of organelle localization cellular localization mitotic metaphase chromosome alignment mitotic cell cycle metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell mitotic sister chromatid segregation chromosome segregation mitotic nuclear division organelle fission chromosome organization sister chromatid segregation establishment of localization nuclear division mitotic cell cycle process nuclear chromosome segregation establishment of chromosome localization regulation of cytoskeleton organization regulation of cellular component organization non-membrane-bounded organelle assembly microtubule cytoskeleton organization regulation of mitotic spindle organization regulation of mitotic spindle assembly microtubule cytoskeleton organization involved in mitosis spindle organization organelle assembly regulation of microtubule-based process regulation of spindle organization regulation of cellular component biogenesis spindle assembly regulation of organelle organization mitotic spindle organization regulation of spindle assembly mitotic spindle assembly regulation of organelle assembly microtubule-based process cytoskeleton organization regulation of microtubule cytoskeleton organization apoptotic process cell death programmed cell death microtubule organizing center organization regulation of centrosome cycle centrosome duplication centrosome cycle regulation of centrosome duplication transport intracellular transport vesicle-mediated transport endosomal transport multivesicular body sorting pathway endosome transport via multivesicular body sorting pathway virion assembly viral process viral budding viral budding via host ESCRT complex viral life cycle late endosome to vacuole transport vacuolar transport membrane fusion organelle membrane fusion endosome to lysosome transport lysosomal transport multivesicular body-lysosome fusion vesicle organization endosome to lysosome transport via multivesicular body sorting pathway lysosome organization vacuole organization lytic vacuole organization lysosomal membrane organization organelle fusion vesicle fusion protein polymerization protein-containing complex assembly multivesicular body assembly multivesicular body organization endosome organization protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization cytoskeleton-dependent cytokinesis mitotic cytokinetic process mitotic cytokinesis midbody abscission cytokinetic process biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress suppression of viral release by host response to external biotic stimulus response to virus regulation of localization regulation of transport regulation of vesicle-mediated transport vesicle-mediated transport between endosomal compartments regulation of early endosome to late endosome transport early endosome to late endosome transport regulation of cellular localization regulation of intracellular transport membrane fission exit from host cell viral release from host cell biological process involved in interaction with host biological process involved in symbiotic interaction non-lytic viral release viral budding from plasma membrane late endosome to lysosome transport wound healing plasma membrane repair plasma membrane organization response to wounding vesicle fusion with vacuole vacuole fusion	extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol endosome membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cellular anatomical entity vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol endosome membrane protein-containing complex ESCRT complex endosome membrane intracellular vesicle membrane protein complex intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane ESCRT III complex organelle membrane vacuolar membrane autophagosome membrane vacuole autophagosome amphisome membrane amphisome nucleus nuclear protein-containing complex organelle envelope nuclear envelope nuclear pore lytic vacuole lytic vacuole membrane lysosomal membrane lysosome midbody multivesicular body membrane late endosome membrane late endosome multivesicular body cell periphery plasma membrane early endosome polymeric cytoskeletal fiber spindle spindle microtubule kinetochore microtubule cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005024	Snf7 family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9Y3E7	attention deficit hyperactivity disorder, inattentive type endogenous depression lung cancer plasma cell myeloma atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma breast cancer lung adenocarcinoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.