3FIA

Crystal structure of the EH 1 domain from human intersectin-1 protein. Northeast Structural Genomics Consortium target HR3646e.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3fiaa_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Eps15 homology domain (EH domain)	8065533	4000946	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	EF-hand	8065534	3001983	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	EF-hand_4	e3fiaA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: EF-hand_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF12763	Cytoskeletal-regulatory complex EF hand (EF-hand_4)	Cytoskeletal-regulatory complex EF hand	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Intersectin-1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding protein binding proline-rich region binding GTPase regulator activity enzyme regulator activity guanyl-nucleotide exchange factor activity nucleoside-triphosphatase regulator activity molecular function regulator activity molecular adaptor activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport establishment of localization in cell intracellular transport protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process establishment of protein localization nitrogen compound transport transport organic substance transport establishment of localization protein transport establishment of localization in cell intracellular transport vesicle-mediated transport endosomal transport cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process small GTPase-mediated signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction synaptic vesicle endocytosis import into cell synaptic vesicle cycle presynaptic endocytosis vesicle-mediated transport in synapse synaptic vesicle endosomal processing synaptic vesicle recycling via endosome synaptic vesicle recycling clathrin-dependent synaptic vesicle endocytosis clathrin-dependent endocytosis receptor-mediated endocytosis endocytosis secretion by cell exocytosis secretion export from cell	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium clathrin-coated pit membrane endomembrane system membrane-bounded organelle intracellular organelle organelle envelope intracellular anatomical structure organelle nuclear envelope nucleus intracellular membrane-bounded organelle cytoplasm cytosol cell periphery plasma membrane presynapse synapse cell junction presynaptic membrane plasma membrane region synaptic membrane neuron projection endosome intracellular vesicle recycling endosome cytoplasmic vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR000219	Dbl homology (DH) domain	Domain
A	IPR000261	EH domain	Domain
A	IPR036028	SH3-like domain superfamily	Homologous Superfamily
A	IPR000008	C2 domain	Domain
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR002048	EF-hand domain	Domain
A	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	Conserved Site
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR001452	SH3 domain	Domain
A	IPR035892	C2 domain superfamily	Homologous Superfamily
A	IPR035899	Dbl homology (DH) domain superfamily	Homologous Superfamily
A	IPR032140	Intersectin-1, AP2 binding region	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q15811	Down syndrome psoriasis prostate cancer Sjogren syndrome adenoma invasive ductal breast carcinoma malignant glioma osteosarcoma pilocytic astrocytoma Prostatic Neoplasms subependymal giant cell astrocytoma astrocytic tumor ductal breast carcinoma in situ large cell medulloblastoma MALT lymphoma Down syndrome psoriasis prostate cancer Sjogren syndrome adenoma invasive ductal breast carcinoma malignant glioma osteosarcoma pilocytic astrocytoma Prostatic Neoplasms subependymal giant cell astrocytoma astrocytic tumor ductal breast carcinoma in situ large cell medulloblastoma MALT lymphoma ovarian cancer primitive neuroectodermal tumor atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma medulloblastoma Pick disease

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.