3FHN

Structure of Tip20p

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Cullin repeat-like	8092383	3000059	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Cullin repeat-like	8092384	3000059	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cullin repeat-like	8092384	3000059	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Cullin repeat-like	8092383	3000059	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cullin repeat-like	8092383	3000059	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Cullin repeat-like	8092384	3000059	SCOP2B (2022-06-29)
D	SCOP2 Family	Tip20p-like	8045916	4004761	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Cullin repeat-like	8092383	3000059	SCOP2 (2022-06-29)
D	SCOP2 Superfamily	Cullin repeat-like	8092384	3000059	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF04437	e3fhnA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04437	ECOD (1.6)
B	PF04437	e3fhnB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04437	ECOD (1.6)
C	PF04437	e3fhnC1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04437	ECOD (1.6)
D	PF04437	e3fhnD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF04437	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	6.10.280.210	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.20.58.1420	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.10.357.100	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
A	1.20.58.670	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
A	1.10.10.2270	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Dsl1p vesicle tethering complex, Tip20p subunit, domain E	CATH (4.3.0)
B	6.10.280.210	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.20.58.1420	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.10.357.100	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
B	1.20.58.670	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
B	1.10.10.2270	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Dsl1p vesicle tethering complex, Tip20p subunit, domain E	CATH (4.3.0)
C	6.10.280.210	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.20.58.1420	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.10.357.100	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
C	1.20.58.670	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
C	1.10.10.2270	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Dsl1p vesicle tethering complex, Tip20p subunit, domain E	CATH (4.3.0)
D	6.10.280.210	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.20.58.1420	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.10.357.100	Mainly Alpha	Orthogonal Bundle	Tetracycline Repressor	domain 2	CATH (4.3.0)
D	1.20.58.670	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
D	1.10.10.2270	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Dsl1p vesicle tethering complex, Tip20p subunit, domain E	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF04437	RINT-1/TIP-1 family (RINT1_TIP1)	RINT-1/TIP-1 family	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Protein transport protein TIP20	-	localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism protein localization localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cellular process establishment of localization Golgi vesicle transport vesicle-mediated transport cellular catabolic process catabolic process cellular metabolic process autophagy metabolic process process utilizing autophagic mechanism protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization regulation of localization regulation of biological process regulation of cellular process regulation of ER to Golgi vesicle-mediated transport regulation of transport biological regulation intracellular transport endoplasmic reticulum to Golgi vesicle-mediated transport regulation of vesicle-mediated transport regulation of cellular localization establishment of localization in cell regulation of intracellular transport	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex intracellular membrane-bounded organelle endomembrane system vesicle tethering complex intracellular organelle Dsl1/NZR complex organelle endoplasmic reticulum endoplasmic reticulum protein-containing complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle protein-containing complex intracellular membrane-bounded organelle endomembrane system vesicle tethering complex intracellular organelle Dsl1/NZR complex organelle endoplasmic reticulum endoplasmic reticulum protein-containing complex organelle subcompartment membrane endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR042042	Protein transport protein Tip20, domain B	Homologous Superfamily
A, B, C, D	IPR042040	Protein transport protein Tip20, domain E	Homologous Superfamily
A, B, C, D	IPR042044	EXOC6/PINT-1/Sec15/Tip20, C-terminal, domain 2	Homologous Superfamily
A, B, C, D	IPR042041	Protein transport protein Tip20, domain A	Homologous Superfamily
A, B, C, D	IPR042043	Protein transport protein Tip20, domain C	Homologous Superfamily
A, B, C, D	IPR007528	RINT-1/Tip20	Family