3FG6

Structure of the C-terminus of Adseverin

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3fg6a1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth C]	d3fg6c1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth G]	d3fg6g1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth E]	d3fg6e1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth F]	d3fg6f1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F [auth H]	d3fg6h1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth D]	d3fg6d1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth B]	d3fg6b1	Alpha and beta proteins (a+b)	Gelsolin-like	Actin depolymerizing proteins	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00626	e3fg6A9	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
B [auth C]	PF00626	e3fg6C3	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
C [auth G]	PF00626	e3fg6G6	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
D [auth E]	PF00626	e3fg6E2	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
E [auth F]	PF00626	e3fg6F2	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
F [auth H]	PF00626	e3fg6H6	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
G [auth D]	PF00626	e3fg6D3	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)
H [auth B]	PF00626	e3fg6B6	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: PF00626	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
B [auth C]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
C [auth G]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
D [auth E]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
E [auth F]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
F [auth H]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
G [auth D]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)
H [auth B]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	PF00626	Gelsolin repeat (Gelsolin)	Gelsolin repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	Adseverin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding actin filament binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding 1-phosphatidylinositol binding modified amino acid binding phosphatidylserine binding	developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of biological process developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development positive regulation of organelle organization regulation of cytoskeleton organization regulation of cellular component organization regulation of cellular process regulation of actin filament-based process positive regulation of cellular component organization positive regulation of biological process cellular component organization regulation of actin nucleation actin filament-based process cellular component organization or biogenesis positive regulation of cellular process regulation of biological process regulation of actin filament organization actin cytoskeleton organization positive regulation of cytoskeleton organization actin filament organization biological regulation positive regulation of supramolecular fiber organization regulation of organelle organization organelle organization positive regulation of actin nucleation regulation of actin cytoskeleton organization regulation of supramolecular fiber organization cellular process actin nucleation supramolecular fiber organization cytoskeleton organization regulated exocytosis transport secretion export from cell establishment of localization vesicle-mediated transport localization secretion by cell exocytosis calcium-ion regulated exocytosis cellular developmental process regulation of developmental process regulation of megakaryocyte differentiation megakaryocyte differentiation cell development regulation of cell differentiation regulation of cell development positive regulation of developmental process positive regulation of cell differentiation cell differentiation regulation of immune system process regulation of multicellular organismal process positive regulation of megakaryocyte differentiation regulation of multicellular organismal development hemopoiesis regulation of myeloid cell differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis actin filament severing positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death regulation of localization regulation of transport regulation of secretion positive regulation of secretion positive regulation of transport cellular component biogenesis cellular component assembly cell projection organization cell projection assembly regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization actin filament capping negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly negative regulation of cellular component organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis negative regulation of organelle organization regulation of actin filament length negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation protein localization cellular macromolecule localization maintenance of location maintenance of protein location cellular localization maintenance of location in cell maintenance of protein location in cell sequestering of actin monomers macromolecule localization regulation of chondrocyte differentiation regulation of cartilage development connective tissue development skeletal system development animal organ development tissue development chondrocyte differentiation cartilage development barbed-end actin filament capping	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle podosome cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle podosome cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle anchoring junction cell junction cluster of actin-based cell projections brush border cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	IPR029006	ADF-H/Gelsolin-like domain superfamily	Homologous Superfamily
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	IPR007122	Villin/Gelsolin	Family
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	IPR036180	Gelsolin-like domain superfamily	Homologous Superfamily
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	IPR007123	Gelsolin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth C], C [auth G], D [auth E], E [auth F], A, B [auth C], C [auth G], D [auth E], E [auth F], F [auth H], G [auth D], H [auth B]	Pharos: Q9Y6U3	astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema glioblastoma lung carcinoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis breast cancer astrocytic tumor cystic fibrosis large cell medulloblastoma malignant glioma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema glioblastoma lung carcinoma malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ulcerative colitis breast cancer interstitial cystitis malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.