3FAV

Structure of the CFP10-ESAT6 complex from Mycobacterium tuberculosis

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3fava_	All alpha proteins	Ferritin-like	EsxAB dimer-like	ESAT-6 like	automated matches	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
C	d3favc_	All alpha proteins	Ferritin-like	EsxAB dimer-like	ESAT-6 like	automated matches	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
B	d3favb_	All alpha proteins	Ferritin-like	EsxAB dimer-like	ESAT-6 like	ESAT-6, EsxA	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)
D	d3favd_	All alpha proteins	Ferritin-like	EsxAB dimer-like	ESAT-6 like	ESAT-6, EsxA	(Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	EsxAB dimer-like	8033009	3001114	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	WXG100_1st	e3favA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: WXG100_1st	ECOD (1.6)
C	WXG100_1st	e3favC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: WXG100_1st	ECOD (1.6)
B	WXG100_1st	e3favB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: WXG100_1st	ECOD (1.6)
D	WXG100_1st	e3favD1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: ESAT-6 like (From Topology)	T: ESAT-6 like	F: WXG100_1st	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)
C	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)
B	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)
D	1.10.287.1060	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	ESAT-6-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF06013	Proteins of 100 residues with WXG (WXG100)	Proteins of 100 residues with WXG	-	Family
B, D	PF06013	Proteins of 100 residues with WXG (WXG100)	Proteins of 100 residues with WXG	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	ESAT-6-like protein esxB	host cell surface binding binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein secretion by the type VII secretion system protein localization to extracellular region transmembrane transport localization protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein secretion by the type VII secretion system protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization cellular process	cell periphery plasma membrane membrane cellular anatomical entity external encapsulating structure cell wall peptidoglycan-based cell wall extracellular region host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum cell periphery plasma membrane membrane cellular anatomical entity external encapsulating structure cell wall peptidoglycan-based cell wall extracellular region host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle host cell surface
B, D	6 kDa early secretory antigenic target	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity host cell surface binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein secretion by the type VII secretion system protein localization to extracellular region transmembrane transport localization protein localization establishment of protein localization cellular localization nitrogen compound transport transport secretion organic substance transport establishment of protein localization to extracellular region export from cell protein secretion establishment of localization protein secretion by the type VII secretion system protein localization to extracellular region transmembrane transport localization secretion by cell protein transmembrane transport protein transport cellular macromolecule localization macromolecule localization cellular process symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms modulation by symbiont of host process symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host defense response response to host defenses response to stimulus response to other organism symbiont-mediated suppression of host T-cell mediated immune response symbiont-mediated perturbation of host immune response response to defenses of other organism response to external stimulus response to biotic stimulus symbiont-mediated suppression of host immune response response to host immune response response to host response to external biotic stimulus symbiont-mediated suppression of host adaptive immune response	extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle intracellular anatomical structure cytoplasm cytosol extracellular region cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region host cell cytoplasm part host intracellular organelle intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane host cell plasma membrane host cell membrane external encapsulating structure cell wall peptidoglycan-based cell wall host cell surface

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR036689	ESAT-6-like superfamily	Homologous Superfamily
A, C	IPR010310	Type VII secretion system ESAT-6-like	Family
B, D	IPR036689	ESAT-6-like superfamily	Homologous Superfamily
B, D	IPR010310	Type VII secretion system ESAT-6-like	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.