3F8U

Tapasin/ERp57 heterodimer

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00085	e3f8uA2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00085	ECOD (1.6)
A	PF13848	e3f8uA8	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF13848	ECOD (1.6)
C	PF00085	e3f8uC4	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF00085	ECOD (1.6)
C	PF13848	e3f8uC6	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF13848	ECOD (1.6)
B	F_UNCLASSIFIED	e3f8uB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B	PF07654	e3f8uB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
D	F_UNCLASSIFIED	e3f8uD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
D	PF07654	e3f8uD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
C	3.40.30.10	Alpha Beta	3-Layer(aba) Sandwich	Glutaredoxin	Glutaredoxin	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF13848	Thioredoxin-like domain (Thioredoxin_6)	Thioredoxin-like domain	-	Domain
A, C	PF00085	Thioredoxin (Thioredoxin)	Thioredoxin	Thioredoxins are small enzymes that participate in redox reactions, via the reversible oxidation of an active centre disulfide bond. Some members with only the active site are not separated from the noise.	Domain
B, D	PF07654	Immunoglobulin C1-set domain (C1-set)	Immunoglobulin C1-set domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Protein disulfide-isomerase A3ERp57	cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity isomerase activity intramolecular oxidoreductase activity intramolecular oxidoreductase activity, transposing S-S bonds protein disulfide isomerase activity RNA binding binding organic cyclic compound binding cysteine-type peptidase activity peptidase activity catalytic activity, acting on a protein cysteine-type endopeptidase activity hydrolase activity catalytic activity endopeptidase activity isomerase activity intramolecular oxidoreductase activity intramolecular oxidoreductase activity, transposing S-S bonds protein disulfide isomerase activity RNA binding binding organic cyclic compound binding nucleic acid binding oxidoreductase activity, acting on a sulfur group of donors disulfide oxidoreductase activity oxidoreductase activity protein-disulfide reductase activity phosphoric ester hydrolase activity hydrolase activity, acting on ester bonds phosphoric diester hydrolase activity phospholipase C activity phospholipase activity lipase activity identical protein binding protein binding	response to stimulus immune response immune system process adaptive immune response organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process response to stimulus immune response immune system process adaptive immune response organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum multicellular organismal process regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis biological regulation platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling cell death extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway signal transduction apoptotic process programmed cell death positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of response to stimulus positive regulation of cellular process regulation of signaling positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway regulation of response to stimulus regulation of cell communication regulation of apoptotic signaling pathway positive regulation of signaling peptide antigen assembly with MHC class I protein complex protein-containing complex organization peptide antigen assembly with MHC protein complex MHC class I protein complex assembly cellular component organization cellular component biogenesis antigen processing and presentation cellular component assembly protein-containing complex assembly antigen processing and presentation of peptide antigen via MHC class I MHC protein complex assembly cellular component organization or biogenesis antigen processing and presentation of peptide antigen response to organic substance response to cytokine response to interleukin-7 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to interleukin-7 cellular response to organic substance cellular response to stress response to endoplasmic reticulum stress	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane-bounded organelle intracellular anatomical structure pigment granule intracellular vesicle intracellular membrane-bounded organelle intracellular organelle melanosome cytoplasmic vesicle organelle cytoplasm vesicle extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle cell surface phagocytic vesicle endocytic vesicle protein-containing complex MHC class I peptide loading complex organelle subcompartment membrane Tapasin-ERp57 complex membrane protein complex endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane endosome membrane endosome recycling endosome cytoplasmic vesicle membrane bounding membrane of organelle recycling endosome membrane vesicle membrane membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen nucleus
B, D	Tapasin	binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class I protein complex binding TAP1 binding TAP binding protein binding unfolded protein binding TAP complex binding molecular adaptor activity MHC class I protein binding binding antigen binding peptide antigen binding peptide binding protein-containing complex binding MHC protein complex binding MHC class I protein complex binding TAP1 binding TAP binding protein binding unfolded protein binding TAP complex binding molecular adaptor activity MHC class I protein binding signaling receptor binding MHC protein binding protein folding chaperone TAP2 binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of protein complex stability biological regulation regulation of biological quality regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of protein complex stability biological regulation regulation of biological quality regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic substance metabolic process biosynthetic process organic substance biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process localization transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum establishment of localization Golgi vesicle transport vesicle-mediated transport peptide stabilization antigen processing and presentation peptide antigen stabilization immune system process antigen processing and presentation of peptide antigen peptide metabolic process antigen processing and presentation of endogenous peptide antigen antigen processing and presentation of peptide antigen via MHC class I antigen processing and presentation of endogenous antigen antigen processing and presentation of endogenous peptide antigen via MHC class I peptide antigen assembly with MHC class I protein complex peptide antigen assembly with MHC protein complex MHC class I protein complex assembly MHC protein complex assembly MHC class Ib protein complex assembly	membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane membrane-bounded organelle intracellular anatomical structure organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane protein-containing complex MHC class I peptide loading complex Tapasin-ERp57 complex membrane protein complex endoplasmic reticulum protein-containing complex lumenal side of endoplasmic reticulum membrane side of membrane lumenal side of membrane intracellular vesicle phagocytic vesicle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane endocytic vesicle membrane vesicle endocytic vesicle Golgi membrane Golgi apparatus endoplasmic reticulum-Golgi intermediate compartment membrane endoplasmic reticulum-Golgi intermediate compartment

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR017937	Thioredoxin, conserved site	Conserved Site
A, C	IPR005788	Protein disulfide-isomerase, thioredoxin-like domain	Domain
A, C	IPR005792	Protein disulphide isomerase	Family
A, C	IPR013766	Thioredoxin domain	Domain
A, C	IPR041868	Protein disulfide-isomerase A3, first redox inactive TRX-like domain b	Domain
A, C	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
B, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, D	IPR003597	Immunoglobulin C1-set	Domain
B, D	IPR008056	Tapasin	Family
B, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: P30101	spinocerebellar ataxia type 17 acute coronary syndrome cancer prostate cancer plasma cell myeloma glioblastoma Liver carcinoma metabolic syndrome X osteosarcoma pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor Crohn disease hepatocellular carcinoma lung adenocarcinoma myopathy spinocerebellar ataxia type 17 acute coronary syndrome cancer prostate cancer plasma cell myeloma glioblastoma Liver carcinoma metabolic syndrome X osteosarcoma pancreatic intraductal papillary-mucinous carcinoma astrocytic tumor Crohn disease hepatocellular carcinoma lung adenocarcinoma myopathy ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia benign neoplasm Duchenne muscular dystrophy juvenile dermatomyositis malignant ependymoma pancreatic ductal adenocarcinoma
B, D	Pharos: O15533	MHC class I deficiency acute myeloid leukemia Bare Lymphocyte Syndrome, Type I endogenous depression juvenile dermatomyositis ovarian cancer schizophrenia astrocytic tumor cervical cancer esophageal adenocarcinoma lung cancer oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma triple-negative breast carcinoma atopic eczema MHC class I deficiency acute myeloid leukemia Bare Lymphocyte Syndrome, Type I endogenous depression juvenile dermatomyositis ovarian cancer schizophrenia astrocytic tumor cervical cancer esophageal adenocarcinoma lung cancer oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma triple-negative breast carcinoma atopic eczema chronic obstructive pulmonary disease glioblastoma malignant ependymoma osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.